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Motivated by DNA-based data storage, we investigate a system where digital information is stored in an unordered set of several vectors over a finite alphabet. Each vector begins with a unique index that represents its position in the whole…

Information Theory · Computer Science 2019-01-23 Andreas Lenz , Paul H. Siegel , Antonia Wachter-Zeh , Eitan Yaakobi

When an individual's DNA is sequenced, sensitive medical information becomes available to the sequencing laboratory. A recently proposed way to hide an individual's genetic information is to mix in DNA samples of other individuals. We…

Information Theory · Computer Science 2024-11-05 Kayvon Mazooji , Roy Dong , Ilan Shomorony

We study the problem of coded information retrieval for block-structured data, motivated by DNA-based storage systems where a database is partitioned into multiple files that must each be recoverable as an atomic unit. We initiate and…

Information Theory · Computer Science 2026-03-19 Daniella Bar-Lev

The prevalent technique for DNA sequencing consists of two main steps: shotgun sequencing, where many randomly located fragments, called reads, are extracted from the overall sequence, followed by an assembly algorithm that aims to…

Genomics · Quantitative Biology 2016-01-28 Shirshendu Ganguly , Elchanan Mossel , Miklos Z. Racz

DNA synthesis is considered as one of the most expensive components in current DNA storage systems. In this paper, focusing on a common synthesis machine, which generates multiple DNA strands in parallel following a fixed supersequence,we…

Information Theory · Computer Science 2025-05-13 Yajuan Liu , Tolga M. Duman

The DNA storage channel is considered, in which the $M$ Deoxyribonucleic acid (DNA) molecules comprising each codeword are stored without order, sampled $N$ times with replacement, and then sequenced over a discrete memoryless channel. For…

Information Theory · Computer Science 2022-02-15 Nir Weinberger , Neri Merhav

DNA sequencing is the basic workhorse of modern day biology and medicine. Shotgun sequencing is the dominant technique used: many randomly located short fragments called reads are extracted from the DNA sequence, and these reads are…

Information Theory · Computer Science 2013-02-15 Abolfazl Motahari , Guy Bresler , David Tse

Data cleansing is a well studied strategy for cleaning erroneous labels in datasets, which has not yet been widely adopted in Music Information Retrieval. Previously proposed data cleansing models do not consider structured (e.g. time…

Machine Learning · Computer Science 2021-04-28 Gabriel Meseguer-Brocal , Rachel Bittner , Simon Durand , Brian Brost

The biochemical processes underlying DNA data storage, including synthesis, amplification, and sequencing, are inherently noisy. Consequently, base-level insertion, deletion, and substitution (IDS) errors, as well as sequence-level…

Information Theory · Computer Science 2026-03-17 Ramy Khabbaz , Jérémy Mateos , Marc Antonini , Serge Kas Hanna

In the emerging field of DNA storage, data is encoded as DNA sequences and stored. The data is read out again by sequencing the stored DNA. Nanopore sequencing is a new sequencing technology that has many advantages over other methods; in…

Information Theory · Computer Science 2021-02-04 Reyna Hulett , Shubham Chandak , Mary Wootters

DNA has many valuable characteristics that make it suitable for a long-term storage medium, in particular its durability and high information density. DNA can be stored safely for hundreds of years with virtually no degradation, in contrast…

Quantitative Methods · Quantitative Biology 2022-05-31 Jamie J. Alnasir , Thomas Heinis , Louis Carteron

The problem of reconstructing strings from their substring spectra has a long history and in its most simple incarnation asks for determining under which conditions the spectrum uniquely determines the string. We study the problem of coded…

Information Theory · Computer Science 2019-04-24 Ryan Gabrys , Olgica Milenkovic

We propose a novel coding scheme for DNA-based storage systems, called the shift-interleave (SI) coding, designed to correct insertion, deletion, and substitution (IDS) errors, as well as sequence losses. The SI coding scheme employs…

Information Theory · Computer Science 2024-01-29 Ryo Shibata , Haruhiko Kaneko

Noisy shuffling channels capture the main characteristics of DNA storage systems where distinct segments of data are received out of order, after being corrupted by substitution errors. For realistic schemes with short-length segments,…

Information Theory · Computer Science 2024-10-07 Javad Haghighat , Tolga M. Duman

A recurrent issue in deep learning is the scarcity of data, in particular precisely annotated data. Few publicly available databases are correctly annotated and generating correct labels is very time consuming. The present article…

Sound · Computer Science 2019-06-25 Celine Jacques , Axel Roebel

Ever since deoxyribonucleic acid (DNA) was considered as a next-generation data-storage medium, lots of research efforts have been made to correct errors occurred during the synthesis, storage, and sequencing processes using error…

Information Theory · Computer Science 2023-06-14 Jaeho Jeong , Hosung Park , Hee-Youl Kwak , Jong-Seon No , Hahyeon Jeon , Jeong Wook Lee , Jae-Won Kim

The main obstacles for the practical deployment of DNA-based data storage platforms are the prohibitively high cost of synthetic DNA and the large number of errors introduced during synthesis. In particular, synthetic DNA products contain…

Image and Video Processing · Electrical Eng. & Systems 2021-01-26 Chao Pan , S. M. Hossein Tabatabaei Yazdi , S Kasra Tabatabaei , Alvaro G. Hernandez , Charles Schroeder , Olgica Milenkovic

Modern biological science produces vast amounts of genomic sequence data. This is fuelling the need for efficient algorithms for sequence compression and analysis. Data compression and the associated techniques coming from information…

Data Structures and Algorithms · Computer Science 2011-09-05 Heba Afify , Muhammad Islam , Manal Abdel Wahed

DNA storage is a promising archival data storage solution to today's big data problem. A DNA storage system encodes and stores digital data with synthetic DNA sequences and decodes DNA sequences back to digital data via sequencing. For…

Emerging Technologies · Computer Science 2024-03-25 Yixun Wei , Bingzhe Li , David Du

DNA based storage systems received attention by many researchers. This includes archival and re-writable random access DNA based storage systems. In this work, we have developed an efficient technique to encode the data into DNA sequence by…

Information Theory · Computer Science 2016-04-25 Dixita Limbachiya , Vijay Dhameliya , Madhav Khakhar , Manish K Gupta