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Comparing two samples of data, we observe a change in the distribution of an outcome variable. In the presence of multiple explanatory variables, how much of the change can be explained by each possible cause? We develop a new estimation…

Mass spectrometry is the dominant technology in the field of proteomics, enabling high-throughput analysis of the protein content of complex biological samples. Due to the complexity of the instrumentation and resulting data, sophisticated…

Causal inference on the average treatment effect (ATE) using non-probability samples, such as electronic health records (EHR), faces challenges from sample selection bias and high-dimensional covariates. This requires considering a…

Methodology · Statistics 2024-03-28 Jiacong Du , Xu Shi , Donglin Zeng , Bhramar Mukherjee

Generalized linear mixed models are useful in studying hierarchical data with possibly non-Gaussian responses. However, the intractability of likelihood functions poses challenges for estimation. We develop a new method suitable for this…

Methodology · Statistics 2022-01-26 Zexi Song , Zhiqiang Tan

Proteomics will celebrate its 20th year in 2014. In this relatively short period of time, it has invaded most areas of biology and its use will probably continue to spread in the future. These two decades have seen a considerable increase…

Genomics · Quantitative Biology 2014-03-24 Thierry Rabilloud , Pierre Lescuyer

Collaboration between different data centers is often challenged by heterogeneity across sites. To account for the heterogeneity, the state-of-the-art method is to re-weight the covariate distributions in each site to match the distribution…

Machine Learning · Statistics 2024-04-25 Tianyu Guo , Sai Praneeth Karimireddy , Michael I. Jordan

This paper proposes a simple yet effective interpolation-based data augmentation approach termed DoubleMix, to improve the robustness of models in text classification. DoubleMix first leverages a couple of simple augmentation operations to…

Computation and Language · Computer Science 2022-09-13 Hui Chen , Wei Han , Diyi Yang , Soujanya Poria

We study the problem of imputing missing values in a dataset, which has important applications in many domains. The key to missing value imputation is to capture the data distribution with incomplete samples and impute the missing values…

Machine Learning · Computer Science 2023-06-26 He Zhao , Ke Sun , Amir Dezfouli , Edwin Bonilla

Balancing the distributions of the confounders across the exposure levels in an observational study through matching or weighting is an accepted method to control for confounding due to these variables when estimating the association…

Methodology · Statistics 2021-08-24 Farhad Pishgar , Noah Greifer , Clémence Leyrat , Elizabeth Stuart

We propose a robust inferential procedure for assessing uncertainties of parameter estimation in high-dimensional linear models, where the dimension $p$ can grow exponentially fast with the sample size $n$. Our method combines the…

Machine Learning · Statistics 2015-03-19 Tianqi Zhao , Mladen Kolar , Han Liu

Clinical decision support using data mining techniques offers more intelligent way to reduce the decision error in the last few years. However, clinical datasets often suffer from high missingness, which adversely impacts the quality of…

Machine Learning · Computer Science 2020-11-20 Xuetong Wu , Hadi Akbarzadeh Khorshidi , Uwe Aickelin , Zobaida Edib , Michelle Peate

We propose a robust hypothesis testing procedure for the predictability of multiple predictors that could be highly persistent. Our method improves the popular extended instrumental variable (IVX) testing (Phillips and Lee, 2013; Kostakis…

Methodology · Statistics 2024-01-03 Xiaosai Liao , Xinjue Li , Qingliang Fan

Multiple imputation provides an effective way to handle missing data. When several possible models are under consideration for the data, the multiple imputation is typically performed under a single-best model selected from the candidate…

Methodology · Statistics 2018-11-30 Gyuhyeong Goh , Jae Kwang Kim

By filling in missing values in datasets, imputation allows these datasets to be used with algorithms that cannot handle missing values by themselves. However, missing values may in principle contribute useful information that is lost…

Machine Learning · Computer Science 2024-10-31 Oliver Urs Lenz , Daniel Peralta , Chris Cornelis

Statistical learning methods for automated variable selection, such as the Least Absolute Shrinkage and Selection Operator (LASSO), elastic nets, and gradient boosting, have become increasingly popular tools for building powerful prediction…

Machine Learning · Statistics 2026-04-13 Robert Kuchen

In today's modern era of Big data, computationally efficient and scalable methods are needed to support timely insights and informed decision making. One such method is sub-sampling, where a subset of the Big data is analysed and used as…

Methodology · Statistics 2022-09-07 Amalan Mahendran , Helen Thompson , James M. McGree

Mutual information (MI) is a fundamental measure of statistical dependence between two variables, yet accurate estimation from finite data remains notoriously difficult. No estimator is universally reliable, and common approaches fail in…

Data Analysis, Statistics and Probability · Physics 2025-10-02 Eslam Abdelaleem , K. Michael Martini , Ilya Nemenman

Qualitative models provide crucial instruments for modelling complex biological systems. While advances in automated reasoning and symbolic encodings have enabled rigorous inference of these models from data, the process remains highly…

Molecular Networks · Quantitative Biology 2026-05-14 Ondřej Huvar , Nikola Beneš , Martin Jonáš , David Šafránek , Samuel Pastva

Nonresponse frequently arises in practice, and simply ignoring it may lead to erroneous inference. Besides, the number of collected covariates may increase as the sample size in modern statistics, so parametric imputation or propensity…

Methodology · Statistics 2022-09-29 Xin He , Xiaojun Mao , Zhonglei Wang

Sampled network data are widely used in empirical research because collecting complete network information is costly. However, empirical analyses based on sampled networks may lead to biased estimators. We propose a nonparametric imputation…

Econometrics · Economics 2026-05-12 Ge Sun , Weisheng Zhang