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Spatial variations in the electrical properties of cardiac tissue can occur because of cardiac diseases. We introduce such gradients into mathematical models for cardiac tissue and then study, by extensive numerical simulations, their…
When propagated action potentials in cardiac tissue interact with local heterogeneities, reflected waves can sometimes be induced. These reflected waves have been associated with the onset of cardiac arrhythmias, and while their generation…
Chirality is one of the most fundamental properties of many physical, chemical and biological systems. However, the mechanisms underlying the onset and control of chiral symmetry are largely understudied. We investigate possibility of…
Spiral waves are spatial-temporal patterns that can emerge in different systems as heart tissues, chemical oscillators, ecological networks and the brain. These waves have been identified in the neocortex of turtles, rats, and humans,…
Spiral waves are investigated in oscillatory media exhibiting period-doubling bifurcations. In the period-doubled and chaotic regimes, the rotational symmetry of the spiral wave is broken. The loss of symmetry takes the form of…
Control strategy for suppression of spiral-wave in a 2-D model of an excitable media is developed with application to the cardiac system. The controller which incorporates a finite number of actuators (electrodes) assures the establishment…
We aim to understand the formation of abnormal waves of activity from myocardial regions with diminished cell-to-cell coupling. In route to this goal, we studied the behavior of a heterogeneous myocyte network in which a sharp coupling…
Nonlinear waves of the reaction-diffusion (RD) type occur in many biophysical systems, including the heart, where they initiate cardiac contraction. Such waves can form vortices called scroll waves, which result in the onset of…
We propose a travelling-wave perturbation method to control the spatiotemporal dynamics in a cardiac model. It is numerically demonstrated that the method can successfully suppress the wave instability (alternans in action potential…
We investigate pattern formation in self-oscillating systems forced by an external periodic perturbation. Experimental observations and numerical studies of reaction-diffusion systems and an analysis of an amplitude equation are presented.…
Three-dimensional excitable systems can selforganize vortex patterns that rotate around one-dimensional phase singularities called filaments. In experiments with the Belousov-Zhabotinsky reaction and numerical simulations, we pin these…
Unbroken and broken spiral waves, in partial-differential-equation (PDE) models for cardiac tissue, are the mathematical analogs of life-threatening cardiac arrhythmias, namely, ventricular tachycardia (VT) and ventricular-fibrillation…
Every sixth death in industrialised countries occurs because of cardiac arrhythmias like ventricular tachycardia (VT) and ventricular fibrillation (VF). There is growing consensus that VT is associated with an unbroken spiral wave of…
Spiral waves are investigated in chemical systems whose underlying spatially-homogeneous dynamics is governed by a deterministic chaotic attractor. We show how the local periodic behavior in the vicinity of a spiral defect is transformed to…
Rotating spiral waves organize spatial patterns in chemical, physical and biological excitable systems. Factors affecting their dynamics such as spatiotemporal drift are of great interest for par- ticular applications. Here, we propose a…
The structure of spiral waves is investigated in super-excitable reaction-diffusion systems where the local dynamics exhibits multi-looped phase space trajectories. It is shown that such systems support stable spiral waves with broken…
Spiral waves are considered to be one of the potential mechanisms that maintains complex arrhythmias such as atrial and ventricular fibrillation. The aim of the present study was to quantify the complex dynamics of spiral waves as the…
The article describes results of the modified model of the Belousov-Zhabotinsky reaction, which resembles rather well the limit set observed upon experimental performance of the reaction in the Petri dish. We discuss the concept of the…
This paper investigates the properties of unstable single-spiral wave solutions arising in the Karma model of two-dimensional cardiac tissue. In particular, we discuss how such solutions can be computed numerically on domains of arbitrary…
Abnormal electrical activity from the boundaries of ischemic cardiac tissue is recognized as one of the major causes in generation of ischemia-reperfusion arrhythmias. Here we present theoretical analysis of the waves of electrical activity…