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Learning uncertain dynamics models using Gaussian process~(GP) regression has been demonstrated to enable high-performance and safety-aware control strategies for challenging real-world applications. Yet, for computational tractability,…

Optimization and Control · Mathematics 2024-09-17 Manish Prajapat , Amon Lahr , Johannes Köhler , Andreas Krause , Melanie N. Zeilinger

Probabilistic models such as Gaussian processes (GPs) are powerful tools to learn unknown dynamical systems from data for subsequent use in control design. While learning-based control has the potential to yield superior performance in…

Systems and Control · Electrical Eng. & Systems 2022-09-22 Alexander von Rohr , Matthias Neumann-Brosig , Sebastian Trimpe

The Intensive Care Unit (ICU) is a hospital department where machine learning has the potential to provide valuable assistance in clinical decision making. Classical machine learning models usually only provide point-estimates and no…

Machine Learning · Computer Science 2024-07-26 David Ruhe , Giovanni Cinà , Michele Tonutti , Daan de Bruin , Paul Elbers

We propose a model predictive control approach for autonomous vehicles that exploits learned Gaussian processes for predicting human driving behavior. The proposed approach employs the uncertainty about the GP's prediction to achieve…

Systems and Control · Electrical Eng. & Systems 2023-03-09 Johanna Bethge , Maik Pfefferkorn , Alexander Rose , Jan Peters , Rolf Findeisen

Safety-critical control using high-dimensional sensory feedback from optical data (e.g., images, point clouds) poses significant challenges in domains like autonomous driving and robotic surgery. Control can rely on low-dimensional states…

The role played by physical activity in slowing down the progression of type-2 diabetes is well recognized. However, except for general clinical guidelines, quantitative real-time estimates of the recommended amount of physical activity,…

Systems and Control · Electrical Eng. & Systems 2025-03-13 Pierluigi Francesco De Paola , Alessandro Borri , Alessia Paglialonga , Pasquale Palumbo , Fabrizio Dabbene

When in a digital control strategy there are samples lost due to limitations, diff t multirate (MR) control options can be used for solving the problem: Dual-rate inferential control (IC) and model-based dual-rate control (MBDR). The…

Optimization and Control · Mathematics 2024-01-19 J. Salt , J. Alcaina , A. Cuenca , A. Banyos

Many robotic tasks, such as human-robot interactions or the handling of fragile objects, require tight control and limitation of appearing forces and moments alongside sensible motion control to achieve safe yet high-performance operation.…

Robotics · Computer Science 2023-03-09 Janine Matschek , Johanna Bethge , Rolf Findeisen

Glucometers present an important self-monitoring tool for diabetes patients and therefore must exhibit high accu- racy as well as good usability features. Based on an invasive, photometric measurement principle that drastically reduces the…

Applications · Statistics 2016-02-11 Nevine Demitri , Abdelhak M. Zoubir

Diabetes is a chronic metabolic disorder characterized by persistently high blood glucose levels (BGLs), leading to severe complications such as cardiovascular disease, neuropathy, and retinopathy. Predicting BGLs enables patients to…

An important issue in quadcopter control is that an accurate dynamic model of the system is nonlinear, complex, and costly to obtain. This limits achievable control performance in practice. Gaussian process (GP) based estimation is an…

Systems and Control · Electrical Eng. & Systems 2021-12-23 Yuhan Liu , Roland Tóth

Safety and tracking stability are crucial for safety-critical systems such as self-driving cars, autonomous mobile robots, industrial manipulators. To efficiently control safety-critical systems to ensure their safety and achieve tracking…

Robotics · Computer Science 2020-09-22 Lei Zheng , Jiesen Pan , Rui Yang , Hui Cheng , Haifeng Hu

Optimal control under uncertainty is a prevailing challenge for many reasons. One of the critical difficulties lies in producing tractable solutions for the underlying stochastic optimization problem. We show how advanced approximate…

Machine Learning · Computer Science 2024-10-28 Joe Watson , Hany Abdulsamad , Rolf Findeisen , Jan Peters

We characterise optimality of bolus insulin inputs, to the Bergman minimal model, by the predicted behaviour of the plasma glucose concentration for a given disturbance. The result is derived subject to the constraints that the plasma…

Optimization and Control · Mathematics 2017-06-27 Christopher Townsend , Maria M. Seron

We present an approach for satisfying state constraints in systems with nonparametric uncertainty by estimating this uncertainty with a real-time-update Gaussian process (GP) model. Notably, new data is incorporated into the model in real…

Systems and Control · Electrical Eng. & Systems 2025-05-13 Ricardo Gutierrez , Jesse B. Hoagg

Simulating Standardized Patients with cognitive impairment offers a scalable and ethical solution for clinical training. However, existing methods rely on discrete prompt engineering and fail to capture the heterogeneity of deficits across…

Artificial Intelligence · Computer Science 2026-04-17 Weikang Zhang , Zimo Zhu , Zhichuan Yang , Chen Huang , Wenqiang Lei , See-Kiong Ng

The goal of this paper is to propose a new mathematical model for the combined effect of different treatments and lifestyles on the glucose-insulin dynamics of Type 2 diabetes (T2D) patients. The model gives the possibility to take into…

Systems and Control · Electrical Eng. & Systems 2023-01-11 Mohamad Al Ahdab , John Leth , Torben Knudsen , Peter Vestergaard , Henrik Clausen

Given the growing prevalence of diabetes, there has been significant interest in determining how diabetes affects instrumental daily functions, like driving. Complication of glucose control in diabetes includes hypoglycemic and…

This work develops a stochastic model predictive controller~(SMPC) for uncertain linear systems with additive Gaussian noise subject to state and control constraints. The proposed approach is based on the recently developed finite-horizon…

Optimization and Control · Mathematics 2019-11-26 Kazuhide Okamoto , Panagiotis Tsiotras

Engineering biology requires precise control of biomolecular circuits, and Cybergenetics is the field dedicated to achieving this goal. A significant challenge in developing controllers for cellular functions is designing systems that can…

Quantitative Methods · Quantitative Biology 2024-09-18 Hamza Faquir , Manuel Pájaro , Irene Otero-Muras