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Deformable registration of magnetic resonance images between patients with brain tumors and healthy subjects has been an important tool to specify tumor geometry through location alignment and facilitate pathological analysis. Since tumor…

Image and Video Processing · Electrical Eng. & Systems 2021-01-19 Xiaofeng Liu , Fangxu Xing , Chao Yang , C. -C. Jay Kuo , Georges ElFakhri , Jonghye Woo

Chemical imaging enables label-free visualization of cells, tissues and living systems while providing direct biochemical information that is difficult to obtain with conventional fluorescence microscopy. Despite its promise in applications…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Yongkang Li , Brian Wong , King Wai Chiu , Hanwen Xu , Tangqi Fang , Erin Dunnington , Dan Fu , Sheng Wang

Magnetic resonance imaging (MRI) is a common and life-saving medical imaging technique. However, acquiring high signal-to-noise ratio MRI scans requires long scan times, resulting in increased costs and patient discomfort, and decreased…

Image and Video Processing · Electrical Eng. & Systems 2023-02-07 Tiange Xiang , Mahmut Yurt , Ali B Syed , Kawin Setsompop , Akshay Chaudhari

The application of supervised models to clinical screening tasks is challenging due to the need for annotated data for each considered pathology. Unsupervised Anomaly Detection (UAD) is an alternative approach that aims to identify any…

Image and Video Processing · Electrical Eng. & Systems 2025-01-24 Finn Behrendt , Debayan Bhattacharya , Robin Mieling , Lennart Maack , Julia Krüger , Roland Opfer , Alexander Schlaefer

Small lesions in magnetic resonance imaging (MRI) images are crucial for clinical diagnosis of many kinds of diseases. However, the MRI quality can be easily degraded by various noise, which can greatly affect the accuracy of diagnosis of…

Image and Video Processing · Electrical Eng. & Systems 2022-09-29 Haibo Yang , Shengjie Zhang , Xiaoyang Han , Botao Zhao , Yan Ren , Yaru Sheng , Xiao-Yong Zhang

The purpose of this study is to present and compare three denoising diffusion probabilistic models (DDPMs) that generate 3D $T_1$-weighted MRI human brain images. Three DDPMs were trained using 80,675 image volumes from 42,406 subjects…

Image and Video Processing · Electrical Eng. & Systems 2025-11-03 Samuel W. Remedios , Aaron Carass , Jerry L. Prince , Blake E. Dewey

In this paper, we propose a method for denoising diffusion-weighted images (DWI) of the brain using a convolutional neural network trained on realistic, synthetic MR data. We compare our results to averaging of repeated scans, a widespread…

Image and Video Processing · Electrical Eng. & Systems 2022-06-02 Jakub Jurek , Andrzej Materka , Kamil Ludwisiak , Agata Majos , Kamil Gorczewski , Kamil Cepuch , Agata Zawadzka

Denoising diffusion models offer a promising approach to accelerating magnetic resonance imaging (MRI) and producing diagnostic-level images in an unsupervised manner. However, our study demonstrates that even tiny worst-case potential…

Image and Video Processing · Electrical Eng. & Systems 2024-06-26 Tianyu Han , Sven Nebelung , Firas Khader , Jakob Nikolas Kather , Daniel Truhn

We address the problem of 3D inconsistency of image inpainting based on diffusion models. We propose a generative model using image pairs that belong to the same scene. To achieve the 3D-consistent and semantically coherent inpainting, we…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Leonid Antsfeld , Boris Chidlovskii

Brain tumors delay the standard preprocessing workflow for further examination. Brain inpainting offers a viable, although difficult, solution for tumor tissue processing, which is necessary to improve the precision of the diagnosis and…

Image and Video Processing · Electrical Eng. & Systems 2025-02-25 Tianli Tao , Ziyang Wang , Han Zhang , Theodoros N. Arvanitis , Le Zhang

3D image reconstruction from a limited number of 2D images has been a long-standing challenge in computer vision and image analysis. While deep learning-based approaches have achieved impressive performance in this area, existing deep…

Computer Vision and Pattern Recognition · Computer Science 2023-10-04 Nivetha Jayakumar , Tonmoy Hossain , Miaomiao Zhang

Diffusion MRI (dMRI) is an advanced imaging technique characterizing tissue microstructure and white matter structural connectivity of the human brain. The demand for high-quality dMRI data is growing, driven by the need for better…

Image and Video Processing · Electrical Eng. & Systems 2024-08-26 Xi Zhu , Wei Zhang , Yijie Li , Lauren J. O'Donnell , Fan Zhang

The generation of medical images presents significant challenges due to their high-resolution and three-dimensional nature. Existing methods often yield suboptimal performance in generating high-quality 3D medical images, and there is…

Image and Video Processing · Electrical Eng. & Systems 2025-12-02 Haoshen Wang , Zhentao Liu , Kaicong Sun , Xiaodong Wang , Dinggang Shen , Zhiming Cui

In this work, we address the limitations of denoising diffusion models (DDMs) in image restoration tasks, particularly the shape and color distortions that can compromise image quality. While DDMs have demonstrated a promising performance…

Computer Vision and Pattern Recognition · Computer Science 2024-12-18 Xinlong Cheng , Tiantian Cao , Guoan Cheng , Bangxuan Huang , Xinghan Tian , Ye Wang , Xiaoyu He , Weixin Li , Tianfan Xue , Xuan Dong

In multiple sclerosis, lesions interfere with automated magnetic resonance imaging analyses such as brain parcellation and deformable registration, while lesion segmentation models are hindered by the limited availability of annotated…

Volumetric optical microscopy using non-diffracting beams enables rapid imaging of 3D volumes by projecting them axially to 2D images but lacks crucial depth information. Addressing this, we introduce MicroDiffusion, a pioneering tool…

Image and Video Processing · Electrical Eng. & Systems 2024-03-19 Mude Hui , Zihao Wei , Hongru Zhu , Fei Xia , Yuyin Zhou

Diffusion MRI is a non-invasive, in-vivo biomedical imaging method for mapping tissue microstructure. Applications include structural connectivity imaging of the human brain and detecting microstructural neural changes. However, acquiring…

Image and Video Processing · Electrical Eng. & Systems 2023-10-09 Amir Sadikov , Xinlei Pan , Hannah Choi , Lanya T. Cai , Pratik Mukherjee

Magnetic resonance imaging (MRI) inpainting supports numerous clinical and research applications. We introduce the first generative model that conditions on voxel-level, continuous tumor concentrations to synthesize high-fidelity brain…

Image and Video Processing · Electrical Eng. & Systems 2025-12-09 Valentin Biller , Lucas Zimmer , Ayhan Can Erdur , Sandeep Nagar , Daniel Rückert , Niklas Bubeck , Jonas Weidner

Despite the ever-increasing interest in applying deep learning (DL) models to medical imaging, the typical scarcity and imbalance of medical datasets can severely impact the performance of DL models. The generation of synthetic data that…

Image and Video Processing · Electrical Eng. & Systems 2023-04-03 Pouria Rouzrokh , Bardia Khosravi , Shahriar Faghani , Mana Moassefi , Sanaz Vahdati , Bradley J. Erickson

Three-dimensional (3D) medical image enhancement, including denoising and super-resolution, is critical for clinical diagnosis in CT, PET, and MRI. Although diffusion models have shown remarkable success in 2D medical imaging, scaling them…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Hongxu Jiang , Fei Li , Boxiao Yu , Ying Zhang , Kaleb Smith , Kuang Gong , Wei Shao