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Human mortality patterns and trajectories in closely related populations are likely linked together and share similarities. It is always desirable to model them simultaneously while taking their heterogeneity into account. This paper…

Methodology · Statistics 2024-12-30 Ka Kin Lam , Bo Wang

The recent increase in morbidity is primarily due to chronic diseases including Diabetes, Heart disease, Lung cancer, and brain tumours. The results for patients can be improved, and the financial burden on the healthcare system can be…

Machine Learning · Computer Science 2025-02-18 Sri Varsha Mulakala , G. Neeharika , P. Vinay Kumar , A. Bhargava Kiran

We investigate state-level age-specific mortality trends based on the United States Mortality Database (USMDB) published by the Human Mortality Database. In tandem with looking at the longevity experience across the 51 states, we also…

Applications · Statistics 2026-03-04 Mike Ludkovski , Doris Padilla

Fast and accurate detection of the disease can significantly help in reducing the strain on the healthcare facility of any country to reduce the mortality during any pandemic. The goal of this work is to create a multimodal system using a…

As the COVID-19 pandemic continues to ravage the world, it is of critical significance to provide a timely risk prediction of the COVID-19 in multi-level. To implement it and evaluate the public health policies, we develop a framework with…

Physics and Society · Physics 2020-12-02 Lingxiao Wang , Tian Xu , Till Hannes Stoecker , Horst Stoecker , Yin Jiang , Kai Zhou

The COVID-19 pandemic has significantly challenged traditional epidemiological models due to factors such as delayed diagnosis, asymptomatic transmission, isolation-induced contact changes, and underreported mortality. In response to these…

Applications · Statistics 2025-03-10 Wenchen Liu , Chang Liu , Dehui Wang , Yiyuan She

Recently, we proposed an state model (compartment model) to describe the progression of a chronic disease with an pre-clinical (undiagnosed) state before clinical diagnosis. It is an open question, if a sequence of cross-sectional studies…

Populations and Evolution · Quantitative Biology 2015-11-24 Ralph Brinks

Nearly 300,000 older adults experience a hip fracture every year, the majority of which occur following a fall. Unfortunately, recovery after fall-related trauma such as hip fracture is poor, where older adults diagnosed with Alzheimer's…

Methodology · Statistics 2024-02-05 Biyi Shen , Haoyu Ren , Michelle Shardell , Jason Falvey , Chixiang Chen

Compartmental models are a tool commonly used in epidemiology for the mathematical modelling of the spread of infectious diseases, with their most popular representative being the Susceptible-Infected-Removed (SIR) model and its…

Machine Learning · Computer Science 2022-12-19 Lorenz Kummer , Kevin Sidak

Disease progression models infer group-level temporal trajectories of change in patients' features as a chronic degenerative condition plays out. They provide unique insight into disease biology and staging systems with individual-level…

Machine Learning · Computer Science 2025-06-25 Peter A. Wijeratne , Daniel C. Alexander

Continuous-time multistate models are widely used for analyzing interval-censored data on disease progression over time. Sometimes, diseases manifest differently and what appears to be a coherent collection of symptoms is the expression of…

Methodology · Statistics 2024-10-08 Yidan Shi , Leilei Zeng , Mary E. Thompson , Suzanne L. Tyas

The methods used so far for the analysis of time changes in population health suffer from the lack of causality in their design. This results in problems with their implementation and interpretation. Here the method is presented with…

Applications · Statistics 2016-02-19 Vladislav Moltchanov

We study an epidemic model for a constant population by taking into account four compartments of the individuals characterizing their states of health. Each individual is in one of the compartments susceptible (S); incubated - infected yet…

Populations and Evolution · Quantitative Biology 2023-04-20 Teo Granger , Thomas M. Michelitsch , Michael Bestehorn , Alejandro P. Riascos , Bernard A. Collet

People are living longer than ever before, and with this arises new complications and challenges for humanity. Among the most pressing of these challenges is of understanding the role of aging in the development of dementia. This paper is…

Methodology · Statistics 2018-08-07 Jonathan P Williams , Curtis B Storlie , Terry M Therneau , Clifford R Jack , Jan Hannig

Prediction of the future trajectory of a disease is an important challenge for personalized medicine and population health management. However, many complex chronic diseases exhibit large degrees of heterogeneity, and furthermore there is…

Machine Learning · Statistics 2016-08-17 Joseph Futoma , Mark Sendak , C. Blake Cameron , Katherine Heller

Accurate epidemic forecasting is crucial for effective disease control and prevention. Traditional compartmental models often struggle to estimate temporally and spatially varying epidemiological parameters, while deep learning models…

Machine Learning · Computer Science 2025-04-08 Shuai Han , Lukas Stelz , Thomas R. Sokolowski , Kai Zhou , Horst Stöcker

Cardiovascular disease (CVD) continues to be the major cause of death globally, calling for predictive models that not only handle diverse and high-dimensional biomedical signals but also maintain interpretability and privacy. We create a…

Machine Learning · Computer Science 2026-01-13 Rohit Kaushik , Eva Kaushik

Objectives: Administrative data is commonly used to inform chronic disease prevalence and support health informatics research. This study assessed the validity of coding comorbidity in the International Classification of Diseases, 10th…

Quantitative Methods · Quantitative Biology 2025-04-02 Jie Pan , Seungwon Lee , Cheligeer Cheligeer , Bing Li , Guosong Wu , Catherine A Eastwood , Yuan Xu , Hude Quan

There is a growing proportion of people with several disease conditions ("multimorbidity"), placing increasing demands on healthcare systems. One hypothesis is that clusters of diseases may arise from shared underlying disease processes…

Methodology · Statistics 2025-08-15 Anthony J. Webster

Disparate areas of machine learning have benefited from models that can take raw data with little preprocessing as input and learn rich representations of that raw data in order to perform well on a given prediction task. We evaluate this…

Machine Learning · Computer Science 2016-09-22 Narges Razavian , Jake Marcus , David Sontag