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Dynamic contrast-enhanced (DCE) MRI is essential for breast cancer diagnosis and treatment. However, its reliance on contrast agents introduces safety concerns, contraindications, increased cost, and workflow complexity. To this end, we…

Image and Video Processing · Electrical Eng. & Systems 2025-09-16 Sebastian Ibarra , Javier del Riego , Alessandro Catanese , Julian Cuba , Julian Cardona , Nataly Leon , Jonathan Infante , Karim Lekadir , Oliver Diaz , Richard Osuala

This paper presents a method for virtual contrast enhancement in breast MRI, offering a promising non-invasive alternative to traditional contrast agent-based DCE-MRI acquisition. Using a conditional generative adversarial network, we…

Image and Video Processing · Electrical Eng. & Systems 2025-05-15 Richard Osuala , Smriti Joshi , Apostolia Tsirikoglou , Lidia Garrucho , Walter H. L. Pinaya , Daniel M. Lang , Julia A. Schnabel , Oliver Diaz , Karim Lekadir

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is essential for breast cancer diagnosis due to its ability to characterize tissue through contrast agent kinetics. However, traditional DCE-MRI protocols require multiple…

Computer Vision and Pattern Recognition · Computer Science 2025-01-28 Ruben D. Fonnegra , Maria Liliana Hernández , Juan C. Caicedo , Gloria M. Díaz

Despite its benefits for tumour detection and treatment, the administration of contrast agents in dynamic contrast-enhanced MRI (DCE-MRI) is associated with a range of issues, including their invasiveness, bioaccumulation, and a risk of…

Image and Video Processing · Electrical Eng. & Systems 2024-06-03 Richard Osuala , Smriti Joshi , Apostolia Tsirikoglou , Lidia Garrucho , Walter H. L. Pinaya , Oliver Diaz , Karim Lekadir

Deep transfer learning using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has shown strong predictive power in characterization of breast lesions. However, pretrained convolutional neural networks (CNNs) require 2D inputs,…

Medical Physics · Physics 2019-11-11 Qiyuan Hu , Heather M. Whitney , Maryellen L. Giger

Introduction: Quantification of dynamic contrast-enhanced (DCE)-MRI has the potential to provide valuable clinical information, but robust pharmacokinetic modeling remains a challenge for clinical adoption. Methods: A 7-layer neural network…

Medical Physics · Physics 2024-05-22 Ouri Cohen , Soudabeh Kargar , Sungmin Woo , Alberto Vargas , Ricardo Otazo

Dynamic contrast-enhanced (DCE) MRI is an evolving imaging technique that provides a quantitative measure of pharmacokinetic (PK) parameters in body tissues, in which series of T1-weighted images are collected following the administration…

Computer Vision and Pattern Recognition · Computer Science 2018-06-13 Cagdas Ulas , Giles Tetteh , Michael J. Thrippleton , Paul A. Armitage , Stephen D. Makin , Joanna M. Wardlaw , Mike E. Davies , Bjoern H. Menze

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) plays an important role in breast cancer screening, tumor assessment, and treatment planning and monitoring. The dynamic changes in contrast in different tissues help to…

Computer Vision and Pattern Recognition · Computer Science 2025-11-21 Rui Wang , Yuexi Du , John Lewin , R. Todd Constable , Nicha C. Dvornek

Iodinated contrast media is essential for dual-energy computed tomography (DECT) angiography. Previous studies show that iodinated contrast media may cause side effects, and the interruption of the supply chain in 2022 led to a severe…

Image and Video Processing · Electrical Eng. & Systems 2023-08-28 Qing Lyu , Josh Tan , Megan E. Lipford , Chuang Niu , Micheal E. Zapadka , Christopher M. Lack , Jonathan D. Clemente , Christopher T. Whitlow , Ge Wang

Magnetic Resonance Imaging (MRI) is instrumental in clinical diagnosis, offering diverse contrasts that provide comprehensive diagnostic information. However, acquiring multiple MRI contrasts is often constrained by high costs, long…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Sanuwani Dayarathna , Kh Tohidul Islam , Bohan Zhuang , Guang Yang , Jianfei Cai , Meng Law , Zhaolin Chen

The adoption of contrast agents in medical imaging protocols is crucial for accurate and timely diagnosis. While highly effective and characterized by an excellent safety profile, the use of contrast agents has its limitation, including…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Davide Bianchi , Sonia Colombo Serra , Davide Evangelista , Pengpeng Luo , Elena Morotti , Giovanni Valbusa

Dynamic contrast enhanced computed tomography (CT) is an imaging technique that provides critical information on the relationship of vascular structure and dynamics in the context of underlying anatomy. A key challenge for image processing…

Breast cancer is the most common malignant tumor among women and the second cause of cancer-related death. Early diagnosis in clinical practice is crucial for timely treatment and prognosis. Dynamic contrast-enhanced magnetic resonance…

Image and Video Processing · Electrical Eng. & Systems 2024-05-13 Zixian Li , Yuming Zhong , Yi Wang

Artificial Intelligence (AI) based image analysis has an immense potential to support diagnostic histopathology, including cancer diagnostics. However, developing supervised AI methods requires large-scale annotated datasets. A potentially…

Contrast-enhanced imaging is central to oncologic diagnosis, but contrast agents can be contraindicated for many of the patients who need them most. Synthesizing contrast scans from non-contrast inputs is the natural response. Two obstacles…

Computer Vision and Pattern Recognition · Computer Science 2026-05-11 Yifan Chen , Fei Yin , Hao Chen , Jia Wu , Chao Li

Style transfer in DCE-MRI is a challenging task due to large variations in contrast enhancements across different tissues and time. Current unsupervised methods fail due to the wide variety of contrast enhancement and motion between the…

Image and Video Processing · Electrical Eng. & Systems 2023-10-23 Adam G. Tattersall , Keith A. Goatman , Lucy E. Kershaw , Scott I. K. Semple , Sonia Dahdouh

Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is a valuable tool to localize, characterize, and evaluate anomalous prostate tissue. Ultrafast gradient-echo acquisitions of MRI volumes are generated at regular time intervals…

Medical Physics · Physics 2017-10-11 Wuilian Torres , Leonardo Cordero , Miguel Martín-Landrove , Antonio Rueda-Toicen

Dynamic Contrast-enhanced Magnetic Resonance Imaging (DCE-MRI) is an important tool for detecting subtle kinetic changes in cancerous tissue. Quantitative analysis of DCE-MRI typically involves the convolution of an arterial input function…

Applications · Statistics 2020-04-22 Volker J. Schmid , Brandon Whitcher , Anwar R. Padhani , Guang-Zhong Yang

Breast cancer is the most prevalent cancer among women and predicting pathologic complete response (pCR) after anti-cancer treatment is crucial for patient prognosis and treatment customization. Deep learning has shown promise in medical…

Image and Video Processing · Electrical Eng. & Systems 2024-10-02 Jonghun Kim , Hyunjin Park

Breast cancer is the second most common type of cancer in women in Canada and the United States, representing over 25\% of all new female cancer cases. As such, there has been immense research and progress on improving screening and…

Computer Vision and Pattern Recognition · Computer Science 2023-08-07 Chi-en Amy Tai , Hayden Gunraj , Nedim Hodzic , Nic Flanagan , Ali Sabri , Alexander Wong
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