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We propose a variational autoencoder (VAE) approach for parameter estimation in nonlinear mixed-effects models based on ordinary differential equations (NLME-ODEs) using longitudinal data from multiple subjects. In moderate dimensions,…

Methodology · Statistics 2026-02-11 Zhe Li , Mélanie Prague , Rodolphe Thiébaut , Quentin Clairon

Cardiac disease evaluation depends on multiple diagnostic modalities: electrocardiogram (ECG) to diagnose abnormal heart rhythms, and imaging modalities such as Magnetic Resonance Imaging (MRI), Computed Tomography (CT) and echocardiography…

Signal Processing · Electrical Eng. & Systems 2024-12-25 Evariste Njomgue Fotso , Buntheng Ly , Hubert Cochet , Maxime Sermesant

Cardiovascular diseases (CVD) can be diagnosed using various diagnostic modalities. The electrocardiogram (ECG) is a cost-effective and widely available diagnostic aid that provides functional information of the heart. However, its ability…

Signal Processing · Electrical Eng. & Systems 2025-01-09 Özgün Turgut , Philip Müller , Paul Hager , Suprosanna Shit , Sophie Starck , Martin J. Menten , Eimo Martens , Daniel Rueckert

Human behavior prediction models enable robots to anticipate how humans may react to their actions, and hence are instrumental to devising safe and proactive robot planning algorithms. However, modeling complex interaction dynamics and…

Robotics · Computer Science 2020-11-24 Boris Ivanovic , Karen Leung , Edward Schmerling , Marco Pavone

Normative modeling learns a healthy reference distribution and quantifies subject-specific deviations to capture heterogeneous disease effects. In Alzheimers disease (AD), multimodal neuroimaging offers complementary signals but VAE-based…

Machine Learning · Computer Science 2026-02-10 Sayantan Kumar , Peijie Qiu , Aristeidis Sotiras

Predicting in-hospital mortality for intensive care unit (ICU) patients is key to final clinical outcomes. AI has shown advantaged accuracy but suffers from the lack of explainability. To address this issue, this paper proposes an…

Machine Learning · Computer Science 2024-01-01 Xingqiao Li , Jindong Gu , Zhiyong Wang , Yancheng Yuan , Bo Du , Fengxiang He

Elucidating the functional mechanisms of the primary visual cortex (V1) remains a fundamental challenge in systems neuroscience. Current computational models face two critical limitations, namely the challenge of cross-modal integration…

Neurons and Cognition · Quantitative Biology 2024-12-20 Yu Zhu , Bo Lei , Chunfeng Song , Wanli Ouyang , Shan Yu , Tiejun Huang

The paper presents the application of Variational Autoencoders (VAE) for data dimensionality reduction and explorative analysis of mass spectrometry imaging data (MSI). The results confirm that VAEs are capable of detecting the patterns…

Quantitative Methods · Quantitative Biology 2017-08-25 Paolo Inglese , James L. Alexander , Anna Mroz , Zoltan Takats , Robert Glen

This paper aims to develop an acoustic signal-based unsupervised anomaly detection method for automatic machine monitoring. Existing approaches such as deep autoencoder (DAE), variational autoencoder (VAE), conditional variational…

Machine Learning · Computer Science 2022-06-14 Harsh Purohit , Takashi Endo , Masaaki Yamamoto , Yohei Kawaguchi

Electrocardiogram (ECG) signal is one of the most effective sources of information mainly employed for the diagnosis and prediction of cardiovascular diseases (CVDs) connected with the abnormalities in heart rhythm. Clearly, single modality…

Signal Processing · Electrical Eng. & Systems 2022-10-13 Thinh Phan , Duc Le , Patel Brijesh , Donald Adjeroh , Jingxian Wu , Morten Olgaard Jensen , Ngan Le

One of the challenges of studying common neurological disorders is disease heterogeneity including differences in causes, neuroimaging characteristics, comorbidities, or genetic variation. Normative modelling has become a popular method for…

Computer Vision and Pattern Recognition · Computer Science 2023-10-03 Ana Lawry Aguila , James Chapman , Andre Altmann

A novel framework for Bayesian structural model updating is presented in this study. The proposed method utilizes the surrogate unimodal encoders of a multimodal variational autoencoder (VAE). The method facilitates an approximation of the…

Machine Learning · Statistics 2024-06-21 Tatsuya Itoi , Kazuho Amishiki , Sangwon Lee , Taro Yaoyama

In medical imaging, anomaly detection is a vital element of healthcare diagnostics, especially for neurological conditions which can be life-threatening. Conventional deterministic methods often fall short when it comes to capturing the…

Machine Learning · Computer Science 2025-04-23 Dip Roy

Multimodal variational autoencoders (VAEs) have emerged as a powerful framework for survival risk modeling in multiple myeloma by integrating heterogeneous omics and clinical data. However, when trained under survival supervision, standard…

Machine Learning · Computer Science 2026-04-09 Zixuan Chen , Heng Zhang , YuPeng Qin , WenPeng Xing , Qiang Wang , Da Wang , Changting Lin , Meng Han

The imperative for early detection of type 2 diabetes mellitus (T2DM) is challenged by its asymptomatic onset and dependence on suboptimal clinical diagnostic tests, contributing to its widespread global prevalence. While research into…

Machine Learning · Computer Science 2024-12-17 Sanjana Gundapaneni , Zhuo Zhi , Miguel Rodrigues

Machine learning models built on training data with multiple modalities can reveal new insights that are not accessible through unimodal datasets. For example, cardiac magnetic resonance images (MRIs) and electrocardiograms (ECGs) are both…

Machine Learning · Computer Science 2023-12-05 Bum Chul Kwon , Samuel Friedman , Kai Xu , Steven A Lubitz , Anthony Philippakis , Puneet Batra , Patrick T Ellinor , Kenney Ng

Cardiovascular disease (CVD) risk stratification remains a major challenge due to its multifactorial nature and limited availability of high-quality labeled datasets. While genomic and electrophysiological data such as SNP variants and ECG…

Quantitative Methods · Quantitative Biology 2025-10-21 Niranjana Arun Menon , Yulong Li , Iqra Farooq , Sara Ahmed , Muhammad Awais , Imran Razzak

Early prediction of respiratory failure is critical for timely clinical intervention in intensive care units. Existing electronic health record (EHR)-based models can continuously monitor physiologic deterioration, but they may not fully…

Image and Video Processing · Electrical Eng. & Systems 2026-05-29 Xiaolei Lu , Shamim Nemati

Prenatal diagnosis of Congenital Heart Diseases (CHDs) holds great potential for Artificial Intelligence (AI)-driven solutions. However, collecting high-quality diagnostic data remains difficult due to the rarity of these conditions,…

Unsupervised learning can leverage large-scale data sources without the need for annotations. In this context, deep learning-based autoencoders have shown great potential in detecting anomalies in medical images. However, especially…

Image and Video Processing · Electrical Eng. & Systems 2020-01-03 David Zimmerer , Simon Kohl , Jens Petersen , Fabian Isensee , Klaus Maier-Hein