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The focus of this work is on spatial variable selection for scalar-on-image regression. We propose a new class of Bayesian nonparametric models, soft-thresholded Gaussian processes and develop the efficient posterior computation algorithms.…

Methodology · Statistics 2016-04-13 Jian Kang , Brian J. Reich , Ana-Maria Staicu

Bayesian Image-on-Scalar Regression (ISR) provides flexible, uncertainty-aware neuroimaging analysis. However, applying ISR to large-scale datasets such as the UK Biobank is challenging due to intensive computational demands and the need to…

Applications · Statistics 2026-02-09 Yuliang Xu , Timothy D. Johnson , Thomas E. Nichols , Jian Kang

A central question in multimodal neuroimaging analysis is to understand the association between two imaging modalities and to identify brain regions where such an association is statistically significant. In this article, we propose a…

Methodology · Statistics 2024-11-28 Moyan Li , Lexin Li , Jian Kang

Motivated by the needs of selecting important features for massive neuroimaging data, we propose a spatially varying coefficient model (SVCMs) with sparsity and piecewise smoothness imposed on the coefficient functions. A new class of…

Methodology · Statistics 2015-05-01 Ran Shi , Jian Kang

In this article, we propose a novel spatial global-local spike-and-slab selection prior for image-on-scalar regression. We consider a Bayesian hierarchical Gaussian process model for image smoothing, that uses a flexible Inverse-Wishart…

Methodology · Statistics 2022-12-19 Zijian Zeng , Meng Li , Marina Vannucci

Most brain disorders are very heterogeneous in terms of their underlying biology and developing analysis methods to model such heterogeneity is a major challenge. A promising approach is to use probabilistic regression methods to estimate…

Machine Learning · Statistics 2018-12-03 Seyed Mostafa Kia , Christian F. Beckmann , Andre F. Marquand

In regression-based analyses of group-level neuroimage data researchers typically fit a series of marginal general linear models to image outcomes at each spatially-referenced pixel. Spatial regularization of effects of interest is usually…

Methodology · Statistics 2024-09-26 Andrew S. Whiteman , Timothy D. Johnson , Jian Kang

In neuroimaging studies, it becomes increasingly important to study associations between different imaging modalities using image-on-image regression (IIR), which faces challenges in interpretation, statistical inference, and prediction.…

Applications · Statistics 2026-03-24 Guoxuan Ma , Bangyao Zhao , Hasan Abu-Amara , Jian Kang

Motivated by recent data analyses in biomedical imaging studies, we consider a class of image-on-scalar regression models for imaging responses and scalar predictors. We propose using flexible multivariate splines over triangulations to…

Methodology · Statistics 2021-06-04 Shan Yu , Guannan Wang , Li Wang , Lijian Yang

We develop a fully Bayesian framework for function-on-scalars regression with many predictors. The functional data response is modeled nonparametrically using unknown basis functions, which produces a flexible and data-adaptive functional…

Methodology · Statistics 2018-10-25 Daniel R. Kowal , Daniel C. Bourgeois

Bayesian methods for learning Gaussian graphical models offer a principled framework for quantifying model uncertainty and incorporating prior knowledge. However, their scalability is constrained by the computational cost of jointly…

Methodology · Statistics 2025-08-28 Reza Mohammadi , Marit Schoonhoven , Lucas Vogels , S. Ilker Birbil

Multi-subject functional magnetic resonance imaging (fMRI) data has been increasingly used to study the population-wide relationship between human brain activity and individual biological or behavioral traits. A common method is to regress…

Applications · Statistics 2015-09-15 Fan Li , Tingting Zhang , Quanli Wang , Marlen Z. Gonzalez , Erin L. Maresh , James A. Coan

Image-on-scalar regression has been a popular approach to modeling the association between brain activities and scalar characteristics in neuroimaging research. The associations could be heterogeneous across individuals in the population,…

Methodology · Statistics 2023-07-04 Zikai Lin , Yajuan Si , Jian Kang

In this paper, we develop a novel spatial variable selection method for scalar on vector-valued image regression in a multi-group setting. Here, 'vector-valued image' refers to the imaging datasets that contain vector-valued information at…

Methodology · Statistics 2024-10-22 Arkaprava Roy , Zhou Lan

Scalar-on-image regression aims to investigate changes in a scalar response of interest based on high-dimensional imaging data. We propose a novel Bayesian nonparametric scalar-on-image regression model that utilises the spatial coordinates…

Methodology · Statistics 2022-06-23 Mica Teo Shu Xian , Sara Wade

Analysis of brain imaging scans is critical to understanding the way the human brain functions, which can be leveraged to treat injuries and conditions that affect the quality of life for a significant portion of the human population. In…

Methodology · Statistics 2022-03-02 Daniel Spencer , David Bolin , Mary Beth Nebel , Amanda Mejia

This paper presents a Bayesian regression model relating scalar outcomes to brain functional connectivity represented as symmetric positive definite (SPD) matrices. Unlike many proposals that simply vectorize the matrix-valued connectivity…

Methodology · Statistics 2024-03-28 Xiaomeng Ju , Hyung G. Park , Thaddeus Tarpey

We propose a novel tensor-on-tensor modeling framework that flexibly models nonlinear voxel-level relationships using Gaussian process (GP) priors, while incorporating the spatial structure of the output tensor through low-rank tensor-based…

Methodology · Statistics 2026-04-10 Yajie Liu , Hengrui Luo , Suprateek Kundu

Multi-task regression attempts to exploit the task similarity in order to achieve knowledge transfer across related tasks for performance improvement. The application of Gaussian process (GP) in this scenario yields the non-parametric yet…

Machine Learning · Statistics 2021-09-21 Haitao Liu , Jiaqi Ding , Xinyu Xie , Xiaomo Jiang , Yusong Zhao , Xiaofang Wang

Recent medical imaging studies have given rise to distinct but inter-related datasets corresponding to multiple experimental tasks or longitudinal visits. Standard scalar-on-image regression models that fit each dataset separately are not…

Methodology · Statistics 2022-01-21 Xin Ma , Suprateek Kundu
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