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The random coefficients model is an extension of the linear regression model that allows for unobserved heterogeneity in the population by modeling the regression coefficients as random variables. Given data from this model, the statistical…

Methodology · Statistics 2018-03-15 Fabian Dunker , Konstantin Eckle , Katharina Proksch , Johannes Schmidt-Hieber

Early detection of breast cancer through screening mammography yields a 20-35% increase in survival rate; however, there are not enough radiologists to serve the growing population of women seeking screening mammography. Although commercial…

Computer Vision and Pattern Recognition · Computer Science 2020-01-24 Stefano Pedemonte , Brent Mombourquette , Alexis Goh , Trevor Tsue , Aaron Long , Sadanand Singh , Thomas Paul Matthews , Meet Shah , Jason Su

Automatic breast lesion detection and classification is an important task in computer-aided diagnosis, in which breast ultrasound (BUS) imaging is a common and frequently used screening tool. Recently, a number of deep learning-based…

Image and Video Processing · Electrical Eng. & Systems 2022-10-13 Zong Fan , Ping Gong , Shanshan Tang , Christine U. Lee , Xiaohui Zhang , Pengfei Song , Shigao Chen , Hua Li

We present a deep convolutional neural network for breast cancer screening exam classification, trained and evaluated on over 200,000 exams (over 1,000,000 images). Our network achieves an AUC of 0.895 in predicting whether there is a…

Gene expression can be used to subtype breast cancer with improved prediction of risk of recurrence and treatment responsiveness over that obtained using routine immunohistochemistry (IHC). However, in the clinic, molecular profiling is…

Computer Vision and Pattern Recognition · Computer Science 2023-05-09 Raktim Kumar Mondol , Ewan K. A. Millar , Peter H Graham , Lois Browne , Arcot Sowmya , Erik Meijering

Differentiating the intrinsic subtypes of breast cancer is crucial for deciding the best treatment strategy. Deep learning can predict the subtypes from genetic information more accurately than conventional statistical methods, but to date,…

Screening mammography is an important front-line tool for the early detection of breast cancer, and some 39 million exams are conducted each year in the United States alone. Here, we describe a multi-scale convolutional neural network (CNN)…

Computer Vision and Pattern Recognition · Computer Science 2017-07-24 William Lotter , Greg Sorensen , David Cox

Lesion detection is a fundamental problem in the computer-aided diagnosis scheme for mammography. The advance of deep learning techniques have made a remarkable progress for this task, provided that the training data are large and…

Image and Video Processing · Electrical Eng. & Systems 2021-11-23 Zheren Li , Zhiming Cui , Sheng Wang , Yuji Qi , Xi Ouyang , Qitian Chen , Yuezhi Yang , Zhong Xue , Dinggang Shen , Jie-Zhi Cheng

Objective: Breast cancer screening is of great significance in contemporary women's health prevention. The existing machines embedded in the AI system do not reach the accuracy that clinicians hope. How to make intelligent systems more…

Computer Vision and Pattern Recognition · Computer Science 2021-07-13 Jian Dai , Shuge Lei , Licong Dong , Xiaona Lin , Huabin Zhang , Desheng Sun , Kehong Yuan

With the rapid development of deep learning and computer vision technologies, medical image segmentation plays a crucial role in the early diagnosis of breast cancer. However, due to the characteristics of breast ultrasound images, such as…

Computer Vision and Pattern Recognition · Computer Science 2024-12-24 Jiajun Ding , Beiyao Zhu , Wenjie Wang , Shurong Zhang , Dian Zhua , Zhao Liua

Cancer evolves continuously over time through a complex interplay of genetic, epigenetic, microenvironmental, and phenotypic changes. This dynamic behavior drives uncontrolled cell growth, metastasis, immune evasion, and therapy resistance,…

Quantitative Methods · Quantitative Biology 2025-07-08 Luoting Zhuang , Stephen H. Park , Steven J. Skates , Ashley E. Prosper , Denise R. Aberle , William Hsu

Joint Models for longitudinal and time-to-event data have gained a lot of attention in the last few years as they are a helpful technique to approach common a data structure in clinical studies where longitudinal outcomes are recorded…

Digital mammography is essential to breast cancer detection, and deep learning offers promising tools for faster and more accurate mammogram analysis. In radiology and other high-stakes environments, uninterpretable ("black box") deep…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Julia Yang , Alina Jade Barnett , Jon Donnelly , Satvik Kishore , Jerry Fang , Fides Regina Schwartz , Chaofan Chen , Joseph Y. Lo , Cynthia Rudin

Breast cancer is a disease that threatens many women's life, thus, early and accurate detection plays a key role in reducing the mortality rate. Mammography stands as the reference technique for breast cancer screening; nevertheless, many…

Image and Video Processing · Electrical Eng. & Systems 2022-02-09 Juan Zuluaga-Gomez , N. Zerhouni , Z. Al Masry , C. Devalland , C. Varnier

Breast cancer, the second leading cause of cancer-related deaths globally, accounts for a quarter of all cancer cases [1]. To lower this death rate, it is crucial to detect tumors early, as early-stage detection significantly improves…

Computer Vision and Pattern Recognition · Computer Science 2025-09-26 Samia Saeed , Khuram Naveed

In recent years, many mammographic image analysis methods have been introduced for improving cancer classification tasks. Two major issues of mammogram classification tasks are leveraging multi-view mammographic information and…

Computer Vision and Pattern Recognition · Computer Science 2023-09-08 Thanh-Huy Nguyen , Quang Hien Kha , Thai Ngoc Toan Truong , Ba Thinh Lam , Ba Hung Ngo , Quang Vinh Dinh , Nguyen Quoc Khanh Le

Accurate diagnosis of breast cancer in histopathology images is challenging due to the heterogeneity of cancer cell growth as well as of a variety of benign breast tissue proliferative lesions. In this paper, we propose a practical and…

Computer Vision and Pattern Recognition · Computer Science 2020-05-06 Xingyu Li , Marko Radulovic , Ksenija Kanjer , Konstantinos N. Plataniotis

Background: Breast cancer is a multifactorial disease, genetic and environmental factors will affect its incidence probability. Breast cancer metastasis is one of the main cause of breast cancer related deaths reported by the American…

Machine Learning · Computer Science 2022-10-13 Chuhan Xu , Xia Jiang

Breast cancer is becoming pervasive with each passing day. Hence, its early detection is a big step in saving the life of any patient. Mammography is a common tool in breast cancer diagnosis. The most important step here is classification…

Computer Vision and Pattern Recognition · Computer Science 2018-01-04 Aditya A. Shastri , Deepti Tamrakar , Kapil Ahuja

Breast cancer is one of the deadliest cancers causing about massive number of patients to die annually all over the world according to the WHO. It is a kind of cancer that develops when the tissues of the breast grow rapidly and unboundly.…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 Mst. Mumtahina Labonno , D. M. Asadujjaman , Md. Mahfujur Rahman , Abdullah Tamim , Mst. Jannatul Ferdous , Rafi Muttaki Mahi