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The aim of this essay is to analyze the role of quantum mechanics as an inherent characteristic of life. During the last ten years the problem of the origin of life has become an innovative research subject approached by many authors. The…

Other Quantitative Biology · Quantitative Biology 2017-09-19 Juan Campos Quemada

The emergence of life from inanimate matter presents a thermodynamic challenge: the Second Law of Thermodynamics dictates a global trend towards disorder, yet life constitutes localized pockets of profound organization. This paper presents…

Statistical Mechanics · Physics 2026-03-17 Shlomo Segal

Due to recent advances in synthetic biology and artificial life, the origin of life is currently a hot topic of research. We review the literature and argue that the two traditionally competing "replicator-first" and "metabolism-first"…

Artificial Intelligence · Computer Science 2013-11-21 Tom Froese , Nathaniel Virgo , Takashi Ikegami

The origin of life is often approached through the lens of replication, heredity, or molecular specificity. This paper proposes a thermodynamic framework in which the emergence of life is driven by the persistence of reaction pathways that…

Biological Physics · Physics 2025-11-25 T. M. Prosser

Life appears to have emerged relatively quickly on the Earth, a fact sometimes used to justify a high rate of spontaneous abiogenesis ($\lambda$) among Earth-like worlds. Conditioned upon a single datum - the time of earliest evidence for…

Earth and Planetary Astrophysics · Physics 2018-12-26 Jingjing Chen , David Kipping

A critical assessment of the recent developments of molecular biology is presented. The thesis that they do not lead to a conceptual understanding of life and biological systems is defended. Maturana and Varela's concept of autopoiesis is…

General Physics · Physics 2009-07-14 Alessandro Sergi

We show that the sheer existence of a quantum computational speedup logically implies the mutually exclusive or of well-defined causal loops. In each of them, it is as if the problem-solver knew in advance one of the possible halves of the…

General Physics · Physics 2025-03-18 Giuseppe Castagnoli

The rapidly increasing interest in the quantum properties of living matter stimulates a discussion of the fundamental properties of life as well as quantum mechanics. In this discussion often concepts are used that originate in philosophy…

History and Philosophy of Physics · Physics 2016-07-27 Alfred Driessen

This thesis broadly concerns the origins of life problem, pursuing a joint approach that combines general philosophical/conceptual reflection on the problem along with more detailed and formal scientific modelling work oriented in the…

Other Quantitative Biology · Quantitative Biology 2016-06-14 Benjamin John Shirt-Ediss

Biosystems contain an almost infinite amount of vital important details, which together ensure their life. There are, however, some common structures and reactions in the systems: the homochirality of carbohydrates and proteins, the…

Biomolecules · Quantitative Biology 2018-03-06 Soren Toxvaerd

Although it has been notoriously difficult to pin down precisely what it is that makes life so distinctive and remarkable, there is general agreement that its informational aspect is one key property, perhaps the key property. The unique…

Adaptation and Self-Organizing Systems · Physics 2012-12-20 Sara Imari Walker , Paul C. W. Davies

The emergence of self-replication and information transmission in life's origin remains unexplained despite extensive research on the topic. A hypothesis explaining the transition from a simple organic world to a complex RNA world is…

Biomolecules · Quantitative Biology 2013-05-27 Stan Palasek

The concept of (auto)catalytic systems has become a cornerstone in understanding evolutionary processes in various fields. The common ground is the observation that for the production of new species/goods/ideas/elements etc. the…

Populations and Evolution · Quantitative Biology 2009-11-13 Rudolf Hanel , Peter Klimek , Stefan Thurner

The origin of life is often framed primarily as a chemical problem, yet life's defining feature is evolution. Advances in geochemistry, prebiotic chemistry, and molecular biology have produced diverse scenarios for the emergence of genomes,…

We apply the theory of learning to physically renormalizable systems in an attempt to develop a theory of biological evolution, including the origin of life, as multilevel learning. We formulate seven fundamental principles of evolution…

Populations and Evolution · Quantitative Biology 2022-10-12 Vitaly Vanchurin , Yuri I. Wolf , Mikhail I. Katsnelson , Eugene V. Koonin

The question of how irreversibility can emerge as a generic phenomena when the underlying mechanical theory is reversible has been a long-standing fundamental problem for both classical and quantum mechanics. We describe a mechanism for the…

Quantum Physics · Physics 2013-09-20 Cozmin Ududec , Nathan Wiebe , Joseph Emerson

Inferring the parameters of models describing biological systems is an important problem in the reverse engineering of the mechanisms underlying these systems. Much work has focused on parameter inference of stochastic and ordinary…

Quantitative Methods · Quantitative Biology 2021-11-09 Thomas Thorne , Paul D. W. Kirk , Heather A. Harrington

While all organisms on Earth descend from a common ancestor, there is no consensus on whether the origin of this ancestral self-replicator was a one-off event or whether it was only the final survivor of multiple origins. Here we use the…

Populations and Evolution · Quantitative Biology 2017-01-17 Nitash C G , Thomas LaBar , Arend Hintze , Christoph Adami

The probability that life spontaneously emerges in a suitable environment (abiogenesis) is one of the major unknowns in astrobiology. Assessing its value is impeded by the lack of an accepted theory for the origin of life, and is further…

Earth and Planetary Astrophysics · Physics 2023-05-10 Amedeo Balbi , Manasvi Lingam

We provide a derivation of quantum theory in which the existence of an energy observable that generates the reversible dynamics follows directly from information-theoretic principles. Our first principle is that every reversible dynamics is…

Quantum Physics · Physics 2026-05-13 Lorenzo Giannelli , Giulio Chiribella
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