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Variational Autoencoders and Generative Adversarial Networks remained the state-of-the-art (SOTA) generative models until 2022. Now they are superseded by diffusion-based models. Efforts to improve traditional models have stagnated as a…

Machine Learning · Computer Science 2026-03-10 Tuhin Subhra De

Foundation models, despite their robust zero-shot capabilities, remain vulnerable to spurious correlations and 'Clever Hans' strategies. Existing mitigation methods often rely on unavailable group labels or computationally expensive…

Machine Learning · Computer Science 2026-05-07 Sidney Bender , Marco Morik

Crystal structure generation is a foundational challenge in materials discovery, particularly in designing functional inorganic crystalline materials with desired properties. Most existing diffusion-based generative models for crystals rely…

Materials Science · Physics 2025-05-13 Sourav Mal , Subhankar Mishra , Prasenjit Sen

Conditional discrete generative models struggle to faithfully compose multiple input conditions. To address this, we derive a theoretically-grounded formulation for composing discrete probabilistic generative processes, with masked…

Machine Learning · Computer Science 2026-04-08 Jamie Stirling , Noura Al-Moubayed , Chris G. Willcocks , Hubert P. H. Shum

Conditional discrete generative models struggle to faithfully compose multiple input conditions. To address this, we derive a theoretically-grounded formulation for composing discrete probabilistic generative processes, with masked…

Computer Vision and Pattern Recognition · Computer Science 2026-04-08 Jamie Stirling , Noura Al-Moubayed , Chris G. Willcocks , Hubert P. H. Shum

Medical image segmentation is inherently an ambiguous task due to factors such as partial volumes and variations in anatomical definitions. While in most cases the segmentation uncertainty is around the border of structures of interest,…

Machine Learning · Statistics 2020-08-05 Raghavendra Selvan , Frederik Faye , Jon Middleton , Akshay Pai

Predicting cellular responses to various perturbations is a critical focus in drug discovery and personalized therapeutics, with deep learning models playing a significant role in this endeavor. Single-cell datasets contain technical…

Machine Learning · Computer Science 2024-09-11 Seungheun Baek , Soyon Park , Yan Ting Chok , Junhyun Lee , Jueon Park , Mogan Gim , Jaewoo Kang

Recent advances in Deep Learning and probabilistic modeling have led to strong improvements in generative models for images. On the one hand, Generative Adversarial Networks (GANs) have contributed a highly effective adversarial learning…

Computer Vision and Pattern Recognition · Computer Science 2018-08-14 Yang He , Bernt Schiele , Mario Fritz

Structured output representation is a generative task explored in computer vision that often times requires the mapping of low dimensional features to high dimensional structured outputs. Losses in complex spatial information in…

Computer Vision and Pattern Recognition · Computer Science 2025-02-25 Mohamed Debbagh

Crystal Structure Prediction (CSP) is crucial in various scientific disciplines. While CSP can be addressed by employing currently-prevailing generative models (e.g. diffusion models), this task encounters unique challenges owing to the…

Materials Science · Physics 2024-03-08 Rui Jiao , Wenbing Huang , Peijia Lin , Jiaqi Han , Pin Chen , Yutong Lu , Yang Liu

The use of machine learning methods for accelerating the design of crystalline materials usually requires manually constructed feature vectors or complex transformation of atom coordinates to input the crystal structure, which either…

Materials Science · Physics 2018-04-10 Tian Xie , Jeffrey C. Grossman

Deep generative models have recently emerged as a promising de novo drug design method. In this respect, deep generative conditional variational autoencoder (CVAE) models are a powerful approach for generating novel molecules with desired…

Machine Learning · Computer Science 2023-08-21 Guang Jun Nicholas Ang , De Tao Irwin Chin , Bingquan Shen

Predicting drop coalescence based on process parameters is crucial for experiment design in chemical engineering. However, predictive models can suffer from the lack of training data and more importantly, the label imbalance problem. In…

Computational Engineering, Finance, and Science · Computer Science 2023-05-02 Kewei Zhu , Sibo Cheng , Nina Kovalchuk , Mark Simmons , Yi-Ke Guo , Omar K. Matar , Rossella Arcucci

The constant demand for new functional materials calls for efficient strategies to accelerate the materials design and discovery. In addressing this challenge, machine learning generative models can offer promising opportunities since they…

Materials Science · Physics 2020-06-24 Sungwon Kim , Juhwan Noh , Geun Ho Gu , Alán Aspuru-Guzik , Yousung Jung

Although machine learning has been successfully used to propose novel molecules that satisfy desired properties, it is still challenging to explore a large chemical space efficiently. In this paper, we present a conditional molecular design…

Machine Learning · Computer Science 2019-04-02 Seokho Kang , Kyunghyun Cho

Recently, the application of diffusion probabilistic models has advanced speech enhancement through generative approaches. However, existing diffusion-based methods have focused on the generation process in high-dimensional waveform or…

Sound · Computer Science 2025-01-20 Shengkui Zhao , Zexu Pan , Kun Zhou , Yukun Ma , Chong Zhang , Bin Ma

Multimodal Variational Autoencoders have emerged as a popular tool to extract effective representations from rich multimodal data. However, such models rely on fusion strategies in latent space that destroy the joint statistical structure…

Machine Learning · Computer Science 2026-03-03 Federico Caretti , Guido Sanguinetti

We propose a method for crystal structure prediction based on a new structure generation algorithm and on-lattice machine learning interatomic potentials. Our algorithm generates the atomic configurations assigning atomic species to sites…

Materials Science · Physics 2023-06-08 Vadim Sotskov , Alexander V. Shapeev , Evgeny V. Podryabinkin

Data augmentation is a powerful technique for improving the performance of the few-shot classification task. It generates more samples as supplements, and then this task can be transformed into a common supervised learning issue for…

Computer Vision and Pattern Recognition · Computer Science 2021-06-29 Yi Zhang , Sheng Huang , Xi Peng , Dan Yang

Discovering new materials is a challenging task in materials science crucial to the progress of human society. Conventional approaches based on experiments and simulations are labor-intensive or costly with success heavily depending on…