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Various multicellular tissues show chiral morphology. Experimental studies have shown this can originate from cell chirality. However, no theory has been proposed to connect the cellular chiral torque and multicellular chiral morphogenesis.…
Cell movement has essential functions in development, immunity and cancer. Various cell migration patterns have been reported and a general rule has recently emerged, the so-called UCSP (Universal Coupling between cell Speed and cell…
An aqueous sodium chloride solution was injected at a controlled rate into a granular bed in a quasi-two-dimensional cell. The granular bed was made of dried, highly water-absorbent gel particles whose swelling rate was controlled by the…
We introduce a multi-species lattice gas model for motor protein driven collective cargo transport on cellular filaments. We use this model to describe and analyze the collective motion of interacting vesicle cargoes being carried by…
Metabolic substrates, such as oxygen and glucose, are rapidly delivered to the cell through filtration across microvessels walls. Modelling this important process is complicated by the coupling between flow and transport equations, which…
Motile eukaryotic cells display distinct modes of migration that often occur within the same cell type. It remains unclear, however, whether transitions between the migratory modes require changes in external conditions, or whether the…
Collective motion of cells is critical to some of the most vital tasks including wound healing, development, and immune response [Friedl and Gilmour 2009; Tokarski et al. 2012; Lee et al. 2012; Beltman et al. 2009], and is common to many…
Collective cell migration in response to a chemical cue occurs in many biological processes such as morphogenesis and cancer metastasis. Clusters of migratory cells in these systems are capable of responding to gradients of less than 1%…
Collective cell migration plays an essential role in various biological processes, such as development or cancer proliferation. While cell-cell interactions are clearly key determinants of collective cell migration -- in addition to…
Transitions between solid-like and fluid-like states in living tissues have been found in steps of embryonic development and in stages of disease progression. Our current understanding of these transitions has been guided by experimental…
Droplets coalescing on flat surfaces tend to end up with the smaller droplet migrating into the larger one. We report a counter-intuitive droplet coalescence pattern on a superhydrophilic cylindrical wire, where the larger droplet is pulled…
Cell motility is fundamental to many biological processes, and cells exhibit a variety of migration patterns. Many motile cell types follow a universal law that connects their speed and persistency, a property that can originate from the…
The flow behavior of a semiflexible polymer in microchannels is studied using Multiparticle Collision Dynamics (MPC), a particle-based hydrodynamic simulation technique. Conformations, distributions, and radial cross-streamline migration…
Film flow through networks of corners and capillary bridges can establish connections between seemingly isolated clusters during drainage in porous media. Coupled with drainage through the bulk of pores and throats, the flow through these…
Cell spreading and motility on an adhesive substrate are driven by the active physical forces generated by the actin cytoskeleton. We have recently shown that coupling curved membrane complexes to protrusive forces, exerted by the actin…
Autologous chemotaxis is the process in which cells secrete and detect molecules to determine the direction of fluid flow. Experiments and theory suggest that autologous chemotaxis fails at high cell densities because molecules from other…
In disordered porous media, two-phase flow of immiscible fluids (biphasic flow) is organized in patterns that sometimes exhibit fractal geometries over a range of length scales, depending on the capillary, gravitational and viscous forces…
Motor-driven cytoskeletal remodeling in cellular systems can often be accompanied by a diffusive-like effect at local scales, but distinguishing the contributions of the ordering process, such as active contraction of a network, from this…
The motility of eukaryotic cells is strongly influenced by their environment, with confined cells often developing qualitatively different motility patterns from those migrating on simple two-dimensional substrates. Recent experiments,…
Generative modeling of single-cell RNA-seq data is crucial for tasks like trajectory inference, batch effect removal, and simulation of realistic cellular data. However, recent deep generative models simulating synthetic single cells from…