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The fastCAT application uses pre-calculated Monte Carlo (MC) CBCT phantom-specific scatter and detector response functions to reduce simulation time for megavoltage (MV) and kilovoltage (kV) CBCT imaging. Pre-calculated x-ray beam energy…

Medical Physics · Physics 2021-09-15 Jericho O'Connell , Magdalena Bazalova-Carter

SPECT (Single-photon Emission Computerized Tomography) and PET (Positron Emission Tomography) are essential medical imaging tools, for which the sampling angle number, scan time should be chosen carefully to compromise between image quality…

Medical Physics · Physics 2015-06-16 Xiaolin Zhou , Minkai Yun , Xuexiang Cao , Shuangquan Liu , Lu Wang , Xianchao Huang , Long Wei

Background: Dual-energy CT (DECT) and material decomposition play vital roles in quantitative medical imaging. However, the decomposition process may suffer from significant noise amplification, leading to severely degraded image…

We report on an hybrid in-beam PET and prompt-gamma Compton imaging system aimed at quasi real-time ion-range verification in proton-therapy treatments. Proof-of-concept experiments were carried out at the radiobiology beam line of the CNA…

Limited-angle computed tomography (LACT) offers improved temporal resolution and reduced radiation dose for cardiac imaging, but suffers from severe artifacts due to truncated projections. To address the ill-posedness of LACT…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Yu Shi , Shuyi Fan , Changsheng Fang , Shuo Han , Haodong Li , Li Zhou , Bahareh Morovati , Dayang Wang , Hengyong Yu

For single source helical Computed Tomography (CT), both Filtered-Back Projection (FBP) and statistical iterative reconstruction have been investigated. However for dual source CT with flying focal spot (DS-FFS CT), statistical iterative…

Image and Video Processing · Electrical Eng. & Systems 2022-02-14 Xiao Wang , Robert D. MacDougall , Peng Chen , Charles A. Bouman , Simon K. Warfield

PET imaging is widely employed for observing biological metabolic activities within the human body. However, numerous benign conditions can cause increased uptake of radiopharmaceuticals, confounding differentiation from malignant tumors.…

Image and Video Processing · Electrical Eng. & Systems 2024-10-31 Ran Hong , Yuxia Huang , Lei Liu , Zhonghui Wu , Bingxuan Li , Xuemei Wang , Qiegen Liu

Reconstructing CT images from incomplete projection data remains challenging due to the ill-posed nature of the problem. Diffusion bridge models have recently shown promise in restoring clean images from their corresponding Filtered Back…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Yuang Wang , Pengfei Jin , Siyeop Yoon , Matthew Tivnan , Shaoyang Zhang , Li Zhang , Quanzheng Li , Zhiqiang Chen , Dufan Wu

We propose a cascaded 3D diffusion model framework to synthesize high-fidelity 3D PET/CT volumes directly from demographic variables, addressing the growing need for realistic digital twins in oncologic imaging, virtual trials, and…

Image and Video Processing · Electrical Eng. & Systems 2025-05-29 Siyeop Yoon , Sifan Song , Pengfei Jin , Matthew Tivnan , Yujin Oh , Sekeun Kim , Dufan Wu , Xiang Li , Quanzheng Li

Numerous dual-energy CT (DECT) techniques have been developed in the past few decades. Dual-energy CT (DECT) statistical iterative reconstruction (SIR) has demonstrated its potential for reducing noise and increasing accuracy. Our lab…

Image and Video Processing · Electrical Eng. & Systems 2023-02-02 Tao Ge , Maria Medrano , Rui Liao , David G. Politte , Jeffrey F. Williamson , Bruce R. Whiting , Joseph A. O'Sullivan

Cone Beam CT (CBCT) is an important imaging modality nowadays, however lower image quality of CBCT compared to more conventional Computed Tomography (CT) remains a limiting factor in CBCT applications. Deep learning reconstruction methods…

Computed Tomography (CT) is a widely used imaging modality in medical and industrial applications. To limit radiation exposure and measurement time, there is a growing interest in sparse-view CT, where the number of projection views is…

Image and Video Processing · Electrical Eng. & Systems 2026-05-04 Luis Barba , Johannes Kirschner , Benjamin Bejar

The analysis of multi-modality positron emission tomography and computed tomography (PET-CT) images for computer aided diagnosis applications requires combining the sensitivity of PET to detect abnormal regions with anatomical localization…

Computer Vision and Pattern Recognition · Computer Science 2019-10-29 Ashnil Kumar , Michael Fulham , Dagan Feng , Jinman Kim

Deep learning based approaches have been used to improve image quality in cone-beam computed tomography (CBCT), a medical imaging technique often used in applications such as image-guided radiation therapy, implant dentistry or…

Computer Vision and Pattern Recognition · Computer Science 2024-03-28 Mohammadreza Amirian , Daniel Barco , Ivo Herzig , Frank-Peter Schilling

The purpose of this study is to determine whether organ sparing and target coverage can be simultaneously maintained for pencil beam scanning (PBS) proton therapy treatment of thoracic tumors in the presence of motion, stopping power…

CBCTs in image-guided radiotherapy provide crucial anatomy information for patient setup and plan evaluation. Longitudinal CBCT image registration could quantify the inter-fractional anatomic changes. The purpose of this study is to propose…

Image and Video Processing · Electrical Eng. & Systems 2023-04-26 Huiqiao Xie , Yang Lei , Yabo Fu , Tonghe Wang , Justin Roper , Jeffrey D. Bradley , Pretesh Patel , Tian Liu , Xiaofeng Yang

Purpose. To alleviate the manual contouring burden, deep learning (DL) based automated contouring has been explored. However, due to the poor contrast resolution of preclinical irradiator CBCT, these methods have been limited to high…

Medical Physics · Physics 2024-02-06 Ethan Cramer , Sophie Dobiasch , Xinmin Liu , Stephanie E. Combs , Rodney D. Wiersma

Upright position CT scans make it possible for full-length-body imaging at conditions more relevant to daily situations, but the substantial weight of the upright CT scanners increases the risks to floor's stability and patients'safety.…

Medical Physics · Physics 2023-11-13 Tong Lin , Tianling Lyu , Zhan Wu , Yan Xi , Wentao Zhu , Yang Chen

Cone Beam Computed Tomography (CBCT) finds diverse applications in medicine. Ensuring high image quality in CBCT scans is essential for accurate diagnosis and treatment delivery. Yet, the susceptibility of CBCT images to noise and artifacts…

Computer Vision and Pattern Recognition · Computer Science 2024-09-30 Yunkui Pang , Yilin Liu , Xu Chen , Pew-Thian Yap , Jun Lian

In digital pathology, acquiring all-in-focus images is essential to high-quality imaging and high-efficient clinical workflow. Traditional scanners achieve this by scanning at multiple focal planes of varying depths and then merging them,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Jiangdong Cai , Yan Chen , Zhenrong Shen , Haotian Jiang , Honglin Xiong , Kai Xuan , Lichi Zhang , Qian Wang
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