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Purpose: To develop high throughput multi-label annotators for body (chest, abdomen, and pelvis) Computed Tomography (CT) reports that can be applied across a variety of abnormalities, organs, and disease states. Approach: We used a…

Background: Artificial intelligence (AI) is improving the efficiency and accuracy of cancer diagnostics. The performance of pathology AI systems has been almost exclusively evaluated on European and US cohorts from large centers. For global…

We present a multi-stage 3D computer-aided detection and diagnosis (CAD) model for automated localization of clinically significant prostate cancer (csPCa) in bi-parametric MR imaging (bpMRI). Deep attention mechanisms drive its detection…

Image and Video Processing · Electrical Eng. & Systems 2021-07-02 Anindo Saha , Matin Hosseinzadeh , Henkjan Huisman

The detection of somatic single nucleotide variants is a crucial component to the characterization of the cancer genome. Mutation calling algorithms thus far have focused on comparing the normal and tumor genomes from the same individual.…

Genomics · Quantitative Biology 2015-06-18 Amie J. Radenbaugh , Singer Ma , Adam Ewing , Joshua Stuart , Eric Collisson , Jingchun Zhu , David Haussler

Renal biopsies are the gold standard for the diagnosis of kidney diseases. Lesion scores made by renal pathologists are semi-quantitative and exhibit high inter-observer variability. Automating lesion classification within segmented…

Computer Vision and Pattern Recognition · Computer Science 2024-12-19 Zhan Xiong , Junling He , Pieter Valkema , Tri Q. Nguyen , Maarten Naesens , Jesper Kers , Fons J. Verbeek

AI for tumor segmentation is limited by the lack of large, voxel-wise annotated datasets, which are hard to create and require medical experts. In our proprietary JHH dataset of 3,000 annotated pancreatic tumor scans, we found that AI…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Qi Chen , Xinze Zhou , Chen Liu , Hao Chen , Wenxuan Li , Zekun Jiang , Ziyan Huang , Yuxuan Zhao , Dexin Yu , Junjun He , Yefeng Zheng , Ling Shao , Alan Yuille , Zongwei Zhou

Despite great advances, molecular cancer pathology is often limited to the use of a small number of biomarkers rather than the whole transcriptome, partly due to computational challenges. Here, we introduce a novel architecture of Deep…

Machine Learning · Statistics 2019-08-14 Behrooz Azarkhalili , Ali Saberi , Hamidreza Chitsaz , Ali Sharifi-Zarchi

Digital pathology and microscopy image analysis are widely employed in the segmentation of digitally scanned IHC slides, primarily to identify cancer and pinpoint regions of interest (ROI) indicative of tumor presence. However, current ROI…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Akash Modi , Sumit Kumar Jha , Purnendu Mishra , Rajiv Kumar , Kiran Aatre , Gursewak Singh , Shubham Mathur

Advances in digitizing tissue slides and the fast-paced progress in artificial intelligence, including deep learning, have boosted the field of computational pathology. This field holds tremendous potential to automate clinical diagnosis,…

Image and Video Processing · Electrical Eng. & Systems 2024-01-17 Andrew H. Song , Guillaume Jaume , Drew F. K. Williamson , Ming Y. Lu , Anurag Vaidya , Tiffany R. Miller , Faisal Mahmood

Digital pathology has emerged as a transformative approach to tissue analysis, offering unprecedented opportunities for objective, quantitative assessment of histopathological features. However, the complexity of implementing artificial…

Quantitative Methods · Quantitative Biology 2025-09-17 Noor Shaker , Mohamed AbouZleikha , Nuha Shaker

Prostate cancer diagnosis through MR imaging have currently relied on radiologists' interpretation, whilst modern AI-based methods have been developed to detect clinically significant cancers independent of radiologists. In this study, we…

Image and Video Processing · Electrical Eng. & Systems 2026-01-09 Xiangcen Wu , Yipei Wang , Qianye Yang , Natasha Thorley , Shonit Punwani , Veeru Kasivisvanathan , Ester Bonmati , Yipeng Hu

Ensuring diagnostic performance of AI models before clinical use is key to the safe and successful adoption of these technologies. Studies reporting AI applied to digital pathology images for diagnostic purposes have rapidly increased in…

The morphometry of a kidney tumor revealed by contrast-enhanced Computed Tomography (CT) imaging is an important factor in clinical decision making surrounding the lesion's diagnosis and treatment. Quantitative study of the relationship…

Whole Slide Images (WSI), obtained by high-resolution digital scanning of microscope slides at multiple scales, are the cornerstone of modern Digital Pathology. However, they represent a particular challenge to AI-based/AI-mediated analysis…

Computer Vision and Pattern Recognition · Computer Science 2024-04-12 Martim Afonso , Praphulla M. S. Bhawsar , Monjoy Saha , Jonas S. Almeida , Arlindo L. Oliveira

Cervical adenocarcinoma in situ (AIS) is a critical premalignant lesion whose accurate histopathological diagnosis is challenging. Early detection is essential to prevent progression to invasive cervical adenocarcinoma. In this study, we…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Gabriela Fernandes

The grade of clear cell renal cell carcinoma (ccRCC) is a critical prognostic factor, making ccRCC nuclei grading a crucial task in RCC pathology analysis. Computer-aided nuclei grading aims to improve pathologists' work efficiency while…

Image and Video Processing · Electrical Eng. & Systems 2021-06-22 Zeyu Gao , Jiangbo Shi , Xianli Zhang , Yang Li , Haichuan Zhang , Jialun Wu , Chunbao Wang , Deyu Meng , Chen Li

Accurate and early detection of breast cancer is essential for successful treatment. This paper introduces a novel deep-learning approach for improved breast cancer classification in histopathological images, a crucial step in diagnosis.…

Image and Video Processing · Electrical Eng. & Systems 2024-03-19 Mahdie Ahmadi , Nader Karimi , Shadrokh Samavi

Cancer diseases constitute one of the most significant societal challenges. In this paper, we introduce a novel histopathological dataset for prostate cancer detection. The proposed dataset, consisting of over 2.6 million tissue patches…

Goal: Squamous cell carcinoma of cervix is one of the most prevalent cancer worldwide in females. Traditionally, the most indispensable diagnosis of cervix squamous carcinoma is histopathological assessment which is achieved under…

Computer Vision and Pattern Recognition · Computer Science 2019-05-28 Ye Tian , Li Yang , Wei Wang , Jing Zhang , Qing Tang , Mili Ji , Yang Yu , Yu Li , Hong Yang , Airong Qian

Acute lymphoblastic leukemia (ALL) is a pervasive pediatric white blood cell cancer across the globe. With the popularity of convolutional neural networks (CNNs), computer-aided diagnosis of cancer has attracted considerable attention. Such…

Computer Vision and Pattern Recognition · Computer Science 2020-06-09 Shiv Gehlot , Anubha Gupta , Ritu Gupta