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Spatially resolved transcriptomics is a fast-developing set of technologies that enables the measurement of localized gene expression across spatial locations in a sample. Detecting spatially varying genes is critical for analyzing such…

Applications · Statistics 2026-04-22 Pritam Dey , Rajarshi Guhaniyogi , Yang Ni , Bani K. Mallick

Stepwise signals are ubiquitous in single-molecule detections, where abrupt changes in signal levels typically correspond to molecular conformational changes or state transitions. However, these features are inevitably obscured by noise,…

Signal Processing · Electrical Eng. & Systems 2026-02-10 Xingdi Tong , Chenyu Wen

Sign language transition generation seeks to convert discrete sign language segments into continuous sign videos by synthesizing smooth transitions. However,most existing methods merely concatenate isolated signs, resulting in poor visual…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 Jiashu He , Jiayi He , Shengeng Tang , Huixia Ben , Lechao Cheng , Richang Hong

Missing data frequently arises across diverse domains, including time-series and image domains. In the real world, missing occurrences often depend on the unobservable values themselves, which are referred to as Missing Not at Random…

Machine Learning · Computer Science 2026-05-26 Gyuwon Sim , Sumin Lee , Heesun Bae , Byeonghu Na , Doyun Kwon , Ju-Hee Hwang , Jae-Young Lim , Il-Chul Moon

Recent advances in multi-modal algorithms have driven and been driven by the increasing availability of large image-text datasets, leading to significant strides in various fields, including computational pathology. However, in most…

Computer Vision and Pattern Recognition · Computer Science 2024-06-21 Jiawen Chen , Muqing Zhou , Wenrong Wu , Jinwei Zhang , Yun Li , Didong Li

When sensors collect spatio-temporal data in a large geographical area, the existence of missing data cannot be escaped. Missing data negatively impacts the performance of data analysis and machine learning algorithms. In this paper, we…

Machine Learning · Computer Science 2019-04-30 Reza Asadi , Amelia Regan

Spatially resolved transcriptomics (ST) measures gene expression along with the spatial coordinates of the measurements. The analysis of ST data involves significant computation complexity. In this work, we propose gene expression…

Genomics · Quantitative Biology 2022-05-24 Zhuoyan Xu , Kris Sankaran

Probabilistic time series imputation has been widely applied in real-world scenarios due to its ability for uncertainty estimation and denoising diffusion probabilistic models~(DDPMs) have achieved great success in probabilistic time series…

Machine Learning · Computer Science 2025-08-20 Hongfan Gao , Wangmeng Shen , Xiangfei Qiu , Ronghui Xu , Jilin Hu , Bin Yang

The rapid development of spatial transcriptomics(ST) enables the measurement of gene expression at spatial resolution, making it possible to simultaneously profile the gene expression, spatial locations of spots, and the matched…

Artificial Intelligence · Computer Science 2024-06-19 Changxi Chi , Hang Shi , Qi Zhu , Daoqiang Zhang , Wei Shao

Semantic image synthesis (SIS) is a task to generate realistic images corresponding to semantic maps (labels). However, in real-world applications, SIS often encounters noisy user inputs. To address this, we propose Stochastic Conditional…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Juyeon Ko , Inho Kong , Dogyun Park , Hyunwoo J. Kim

Recent advances on text-to-image generation have witnessed the rise of diffusion models which act as powerful generative models. Nevertheless, it is not trivial to exploit such latent variable models to capture the dependency among discrete…

Computer Vision and Pattern Recognition · Computer Science 2022-12-07 Jianjie Luo , Yehao Li , Yingwei Pan , Ting Yao , Jianlin Feng , Hongyang Chao , Tao Mei

Single-cell spatial transcriptomics (ST) offers a unique approach to measuring gene expression profiles and spatial cell locations simultaneously. However, most existing ST methods assume that cells in closer spatial proximity exhibit more…

Genomics · Quantitative Biology 2025-06-10 Xiongtao Xiao , Xiaofeng Chen , Feiyan Jiang , Songming Zhang , Wenming Cao , Cheng Tan , Zhangyang Gao , Zhongshan Li

Spatial transcriptomics is an emerging technology that aligns histopathology images with spatially resolved gene expression profiling. It holds the potential for understanding many diseases but faces significant bottlenecks such as…

Computer Vision and Pattern Recognition · Computer Science 2024-01-12 Gabriel Mejia , Paula Cárdenas , Daniela Ruiz , Angela Castillo , Pablo Arbeláez

Trajectory prediction is a crucial undertaking in understanding entity movement or human behavior from observed sequences. However, current methods often assume that the observed sequences are complete while ignoring the potential for…

Computer Vision and Pattern Recognition · Computer Science 2023-03-29 Yi Xu , Armin Bazarjani , Hyung-gun Chi , Chiho Choi , Yun Fu

The effectiveness of spectral-spatial feature learning is crucial for the hyperspectral image (HSI) classification task. Diffusion models, as a new class of groundbreaking generative models, have the ability to learn both contextual…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Jingyi Zhou , Jiamu Sheng , Jiayuan Fan , Peng Ye , Tong He , Bin Wang , Tao Chen

Unsupervised anomaly segmentation aims to detect patterns that are distinct from any patterns processed during training, commonly called abnormal or out-of-distribution patterns, without providing any associated manual segmentations. Since…

Image and Video Processing · Electrical Eng. & Systems 2023-11-06 Ziyun Liang , Harry Anthony , Felix Wagner , Konstantinos Kamnitsas

Spatio-temporal (ST) prediction is an important and widely used technique in data mining and analytics, especially for ST data in urban systems such as transportation data. In practice, the ST data generation is usually influenced by…

Machine Learning · Computer Science 2024-03-08 Jiahao Ji , Jingyuan Wang , Yu Mou , Cheng Long

Sparsity and missing data problems are very common in spatiotemporal traffic data collected from various sensing systems. Making accurate imputation is critical to many applications in intelligent transportation systems. In this paper, we…

Machine Learning · Statistics 2020-06-12 Xinyu Chen , Jinming Yang , Lijun Sun

Spatial transcriptomics (ST) is an emerging technology that enables researchers to investigate the molecular relationships underlying tissue morphology. However, acquiring ST data remains prohibitively expensive, and traditional fixed-grid…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Junchao Zhu , Ruining Deng , Junlin Guo , Tianyuan Yao , Chongyu Qu , Juming Xiong , Siqi Lu , Zhengyi Lu , Yanfan Zhu , Marilyn Lionts , Yuechen Yang , Yalin Zheng , Yu Wang , Shilin Zhao , Haichun Yang , Yuankai Huo

Spatial transcriptomics (ST) maps gene expression within tissue at individual spots, making it a valuable resource for multimodal representation learning. Additionally, ST inherently contains rich hierarchical information both across and…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Xulin Chen , Junzhou Huang