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While virtual try-on has achieved significant progress, evaluating these models towards real-world scenarios remains a challenge. A comprehensive benchmark is essential for three key reasons:(1) Current metrics inadequately reflect human…

Computer Vision and Pattern Recognition · Computer Science 2025-05-27 Hu Xiaobin , Liang Yujie , Luo Donghao , Peng Xu , Zhang Jiangning , Zhu Junwei , Wang Chengjie , Fu Yanwei

Describing the relationship between the variables in a study domain and modelling the data generating mechanism is a fundamental problem in many empirical sciences. Probabilistic graphical models are one common approach to tackle the…

Machine Learning · Statistics 2023-12-05 Felix L. Rios , Giusi Moffa , Jack Kuipers

Designing compounds with desired properties is a key element of the drug discovery process. However, measuring progress in the field has been challenging due to the lack of realistic retrospective benchmarks, and the large cost of…

Biomolecules · Quantitative Biology 2023-06-16 Tobiasz Cieplinski , Tomasz Danel , Sabina Podlewska , Stanislaw Jastrzebski

Virtual screening plays a critical role in modern drug discovery by enabling the identification of promising candidate molecules for experimental validation. Traditional machine learning methods such, as Support Vector Machines (SVM) and…

Machine Learning · Computer Science 2025-04-29 Radia Berreziga , Mohammed Brahimi , Khairedine Kraim , Hamid Azzoune

The characterization of drug-protein interactions is crucial in the high-throughput screening for drug discovery. The deep learning-based approaches have attracted attention because they can predict drug-protein interactions without…

Machine Learning · Computer Science 2020-12-22 QHwan Kim , Joon-Hyuk Ko , Sunghoon Kim , Nojun Park , Wonho Jhe

Progress in hardware model checking depends critically on high-quality benchmarks. However, the community faces a significant benchmark gap: existing suites are limited in number, often distributed only in representations such as BTOR2…

Hardware Architecture · Computer Science 2026-02-27 Guangyu Hu , Xiaofeng Zhou , Wei Zhang , Hongce Zhang

Statistical shape modeling (SSM) enables population-based quantitative analysis of anatomical shapes, informing clinical diagnosis. Deep learning approaches predict correspondence-based SSM directly from unsegmented 3D images but require…

Computer Vision and Pattern Recognition · Computer Science 2023-07-21 Jadie Adams , Shireen Elhabian

The systematic evaluation and understanding of computer vision models under varying conditions require large amounts of data with comprehensive and customized labels, which real-world vision datasets rarely satisfy. While current synthetic…

Drug discovery represents a time-consuming and financially intensive process, and virtual screening can accelerate it. Scoring functions, as one of the tools guiding virtual screening, have their precision closely tied to screening…

Machine Learning · Computer Science 2026-01-13 Haotian Gao , Xiangying Zhang , Jingyuan Li , Xinchong Chen , Haojie Wang , Yifei Qi , Renxiao Wang

Vision Foundation Models (VFMs) are large-scale, pre-trained models that serve as general-purpose backbones for various computer vision tasks. As VFMs' popularity grows, there is an increasing interest in understanding their effectiveness…

Computer Vision and Pattern Recognition · Computer Science 2025-05-06 Volodymyr Havrylov , Haiwen Huang , Dan Zhang , Andreas Geiger

The need for efficient computational screening of molecular candidates that possess desired properties frequently arises in various scientific and engineering problems, including drug discovery and materials design. However, the large size…

Optimization and Control · Mathematics 2023-01-05 Hyun-Myung Woo , Xiaoning Qian , Li Tan , Shantenu Jha , Francis J. Alexander , Edward R. Dougherty , Byung-Jun Yoon

Joint vision-language models have shown great performance over a diverse set of tasks. However, little is known about their limitations, as the high dimensional space learned by these models makes it difficult to identify semantic errors.…

Computer Vision and Pattern Recognition · Computer Science 2023-06-01 Santiago Castro , Oana Ignat , Rada Mihalcea

Virtual screening is an early stage of the drug discovery process that selects the most promising candidates. In the urgent computing scenario it is critical to find a solution in a short time frame. In this paper, we focus on a real-world…

Computational Engineering, Finance, and Science · Computer Science 2023-03-14 Gianmarco Accordi , Emanuele Vitali , Davide Gadioli , Luigi Crisci , Biagio Cosenza , Mauro Bisson , Massimiliano Fatica , Andrea Beccari , Gianluca Palermo

Tandem mass spectrometry provides a high-throughput framework for identifying and quantifying proteins in complex biological samples. In computational proteomics, predicting peptide MS/MS spectra is a critical task, enabling downstream…

Machine Learning · Computer Science 2026-05-05 Zhiwen Yang , Pan Liu , Yifan Li , Yunhua Zhong , Jun Xia

Computer vision leveraging deep learning has achieved significant success in the last decade. Despite the promising performance of the existing deep models in the recent literature, the extent of models' reliability remains unknown.…

Computer Vision and Pattern Recognition · Computer Science 2020-04-13 Seyed Omid Sajedi , Xiao Liang

In structure-based virtual screening, it is often necessary to evaluate the binding free energy of protein-ligand complexes by considering not only molecular conformations but also how these structures shift and rotate in space. The number…

Quantum Physics · Physics 2025-07-25 Pei-Kun Yang

Embedding-based retrieval methods construct vector indices to search for document representations that are most similar to the query representations. They are widely used in document retrieval due to low latency and decent recall…

Stacking (or stacked generalization) is an ensemble learning method with one main distinctiveness from the rest: even though several base models are trained on the original data set, their predictions are further used as input data for one…

Machine Learning · Computer Science 2024-04-19 Ilya Ploshchik , Angelos Chatzimparmpas , Andreas Kerren

Complex-Valued Neural Networks (CVNNs) have significant advantages in handling tasks that involve complex numbers. However, existing CVNNs are unable to quantify predictive uncertainty. We propose, for the first time, dropout-based Bayesian…

Hardware Architecture · Computer Science 2026-04-23 Zehuan Zhang , Mark Chen , He Li , Wayne Luk

In this paper, we compare predictive models for students' final performance in a blended course using a set of generic features collected from the first six weeks of class. These features were extracted from students' online homework…

Artificial Intelligence · Computer Science 2018-12-04 Hengxuan Li , Collin F. Lynch , Tiffany Barnes