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An efficient and trajectory-free active learning method is proposed to automatically sample data points for constructing globally accurate reactive potential energy surfaces (PESs) using neural networks (NNs). Although NNs do not provide…

Chemical Physics · Physics 2020-05-20 Qidong Lin , Yaolong Zhang , Bin Zhao , Bin Jiang

We introduce an explorative active learning (AL) algorithm based on Gaussian process regression and marginalized graph kernel (GPR-MGK) to explore chemical space with minimum cost. Using high-throughput molecular dynamics simulation to…

Machine Learning · Computer Science 2022-09-02 Yan Xiang , Yu-Hang Tang , Zheng Gong , Hongyi Liu , Liang Wu , Guang Lin , Huai Sun

High-throughput solid-state nanopore experiments generate continuous MHz-rate data streams in which only a small fraction of data contains informative molecular information. This creates storage and processing bottlenecks that limit…

Machine Learning (ML) approximations to Density Functional Theory (DFT) potential energy surfaces (PESs) are showing great promise for reducing the computational cost of accurate molecular simulations, but at present they are not applicable…

Chemical Physics · Physics 2020-03-05 Xiaowei Xie , Kristin A. Persson , David W. Small

Designing a lightweight semantic segmentation network often requires researchers to find a trade-off between performance and speed, which is always empirical due to the limited interpretability of neural networks. In order to release…

Computer Vision and Pattern Recognition · Computer Science 2020-04-02 Peiwen Lin , Peng Sun , Guangliang Cheng , Sirui Xie , Xi Li , Jianping Shi

Multireference electron correlation methods describe static and dynamical electron correlation in a balanced way, and therefore, can yield accurate and predictive results even when single-reference methods or multiconfigurational…

Chemical Physics · Physics 2019-11-19 Jae Woo Park , Rachael Al-Saadon , Matthew K. MacLeod , Toru Shiozaki , Bess Vlaisavljevich

We leverage physics-embedded differentiable graph network simulators (GNS) to accelerate particulate and fluid simulations to solve forward and inverse problems. GNS represents the domain as a graph with particles as nodes and learned…

Geophysics · Physics 2023-09-26 Krishna Kumar , Yongjin Choi

Characterizing conformational transitions in physical systems remains a fundamental challenge, as traditional sampling methods struggle with the high-dimensional nature of molecular systems and high-energy barriers between stable states.…

Chemical Physics · Physics 2025-09-22 Magnus Petersen , Gemma Roig , Roberto Covino

Graph Neural Architecture Search (GNAS) has achieved superior performance on various graph-structured tasks. However, existing GNAS studies overlook the applications of GNAS in resource-constraint scenarios. This paper proposes to design a…

Machine Learning · Computer Science 2024-06-25 Beini Xie , Heng Chang , Ziwei Zhang , Zeyang Zhang , Simin Wu , Xin Wang , Yuan Meng , Wenwu Zhu

The canonical solution methodology for finite constrained Markov decision processes (CMDPs), where the objective is to maximize the expected infinite-horizon discounted rewards subject to the expected infinite-horizon discounted costs…

Machine Learning · Computer Science 2020-05-11 Sami Khairy , Prasanna Balaprakash , Lin X. Cai

Deformable granular terrains introduce significant locomotion and immobilization risks in planetary exploration and are difficult to detect via remote sensing (e.g., vision). Legged robots can sense terrain properties through leg-terrain…

Robotics · Computer Science 2026-03-11 Matthew Y. Jiang , Feifei Qian , Shipeng Liu

Simulations of chemical reaction probabilities in gas surface dynamics require the calculation of ensemble averages over many tens of thousands of reaction events to predict dynamical observables that can be compared to experiments. At the…

Energy landscapes provide a valuable means for studying the folding dynamics of short RNA molecules in detail by modeling all possible structures and their transitions. Higher abstraction levels based on a macro-state decomposition of the…

Biomolecules · Quantitative Biology 2014-09-09 Martin Mann , Marcel Kucharik , Christoph Flamm , Michael T. Wolfinger

Graph-based Approximate Nearest Neighbor Search (ANNS) is widely adopted in numerous applications, such as recommendation systems, natural language processing, and computer vision. While recent works on GPU-based acceleration have…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-07-24 Sukjin Kim , Seongyeon Park , Si Ung Noh , Junguk Hong , Taehee Kwon , Hunseong Lim , Jinho Lee

The dynamic energy sector requires both predictive accuracy and runtime efficiency for short-term forecasting of energy generation under operational constraints, where timely and precise predictions are crucial. The manual configuration of…

Machine Learning · Computer Science 2025-11-04 Georg Velev , Stefan Lessmann

The rise of machine learning has greatly influenced the field of computational chemistry, and that of atomistic molecular dynamics simulations in particular. One of its most exciting prospects is the development of accurate,…

Chemical Physics · Physics 2023-06-14 Silvan Käser , Markus Meuwly

Efficiently identifying the right trajectories for training remains an open problem in GFlowNets. To address this, it is essential to prioritize exploration in regions of the state space where the reward distribution has not been…

Machine Learning · Computer Science 2025-10-23 Sajan Muhammad , Salem Lahlou

In this work, we propose a multi-scale protocol for routine theoretical studies of chemical reaction mechanisms. The initial reaction paths of our investigated systems are sampled using the Nudged-Elastic Band (NEB) method driven by a cheap…

Chemical Physics · Physics 2023-07-26 Tomislav Piskor , Peter Pinski , Thilo Mast , Vladimir V. Rybkin

Reactive chemistry of molecular hydrogen at surfaces, notably dissociative sticking and hydrogen evolution, plays a crucial role in energy storage and fuel cells. Theoretical studies can help to decipher underlying mechanisms and reaction…

An enhanced geothermal system is essential to provide sustainable and long-term geothermal energy supplies and reduce carbon emissions. Optimal well-control scheme for effective heat extraction and improved heat sweep efficiency plays a…

Neural and Evolutionary Computing · Computer Science 2022-12-20 Guodong Chen , Xin Luo , Chuanyin Jiang , Jiu Jimmy Jiao