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Mechanical properties of tissue provide valuable information for identifying lesions. One approach to obtain quantitative estimates of elastic properties is shear wave elastography with optical coherence elastography (OCE). However, given…

Image and Video Processing · Electrical Eng. & Systems 2020-04-30 Maximilian Neidhardt , Marcel Bengs , Sarah Latus , Matthias Schlüter , Thore Saathoff , Alexander Schlaefer

The mechanical properties of arterial walls are critical for maintaining vascular function under pulsatile pressure and are closely linked to the development of cardiovascular diseases. Despite advances in imaging and elastography,…

Biological Physics · Physics 2025-07-29 Yuxuan Jiang , Guo-Yang Li , Ruizhi Wang , Xu Feng , Yanhang Zhang , Seok-Hyun Yun

Objective: The mechanical properties of corneal tissues play a crucial role in determining corneal shape and have significant implications in vision care. This study aimed to address the challenge of obtaining accurate in vivo data for the…

Medical Physics · Physics 2023-07-11 Guo-Yang Li , Xu Feng , Seok-Hyun Yun

Tissue stiffness is related to soft tissue pathologies and can be assessed through palpation or via clinical imaging systems, e.g., ultrasound or magnetic resonance imaging. Typically, the image based approaches are not suitable during…

Signal Processing · Electrical Eng. & Systems 2025-09-04 Maximilian Neidhardt , Sarah Latus , Tim Eixmann , Gereon Hüttmann , Alexander Schlaefer

The distinction between malignant and benign tumors is essential to the treatment of cancer. The tissue's elasticity can be used as an indicator for the required tissue characterization. Optical coherence elastography (OCE) probes have been…

Image and Video Processing · Electrical Eng. & Systems 2021-09-21 Robin Mieling , Johanna Sprenger , Sarah Latus , Lennart Bargsten , Alexander Schlaefer

Lens tension is essential for accommodative vision but remains difficult to measure with precision. Here, we present an optical coherence elastography (OCE) technique that quantifies both tension and elastic modulus in the lens capsule and…

Applied Physics · Physics 2025-12-29 Xu Feng , Guo-yang Li , Yuxuan Jiang , Owen Shortt-Nguyen , Seok-Hyun Yun

Elasticity is a fundamental cellular property that is related to the anatomy, functionality and pathological state of cells and tissues. However, current techniques based on cell deformation, atomic force microscopy or Brillouin scattering…

Optical coherence elastography (OCE) is a powerful non-invasive imaging technique for high-resolution assessment of tissue elasticity and viscoelasticity. Accurate characterization of viscoelastic properties requires estimating shear wave…

Dynamic optical coherence elastography (OCE) tracks mechanical wave propagation in the subsurface region of tissue to image its shear modulus. For bulk shear waves, the lateral resolution of the reconstructed modulus map (i.e.,…

Traveling-wave optical coherence elastography (OCE) is a promising technique to measure the stiffness of biological tissues. While OCE has been applied to relatively homogeneous samples, tissues with significantly varying elasticity through…

Medical Physics · Physics 2022-01-31 Xu Feng , Guo-Yang Li , Antoine Ramier , Amira M. Eltony , Seok-Hyun Yun

Visualizing elastic waves by noninvasive imaging has been useful for analyzing the mechanical properties of materials and tissues. However, the maximum wave frequency of elastography has been limited to ~10 kHz due to the finite sensitivity…

Applied Physics · Physics 2022-11-22 Xu Feng , Guo-Yang Li , Seok-Hyun Yun

Surgical robotics is a rising field in medical technology and advanced robotics. Robot assisted surgery, or robotic surgery, allows surgeons to perform complicated surgical tasks with more precision, automation, and flexibility than is…

Robotics · Computer Science 2023-11-02 A. E. Abdelaal , S. N. Zaman , P. Y Chen , T. Suzuki , J. Ingleton

Purpose Surgical simulations play an increasingly important role in surgeon education and developing algorithms that enable robots to perform surgical subtasks. To model anatomy, Finite Element Method (FEM) simulations have been held as the…

Robotics · Computer Science 2020-03-27 Jie Ying Wu , Peter Kazanzides , Mathias Unberath

Purpose. To demonstrate accurate measurement of corneal elastic moduli in vivo with non-contact and non-invasive optical coherence elastography. Methods. Elastic properties (in-plane Young's modulus E and both in-plane, u, and out-of-plane,…

Diagnostic activities, such as ultrasound scans and palpation, are relatively low-cost. They play a crucial role in the early detection of health problems and in assessing their progression. However, they are also error-prone activities,…

Ultrasound shear wave elasticity imaging is a valuable tool for quantifying the elastic properties of tissue. Typically, the shear wave velocity is derived and mapped to an elasticity value, which neglects information such as the shape of…

Image and Video Processing · Electrical Eng. & Systems 2022-04-29 Maximilian Neidhardt , Marcel Bengs , Sarah Latus , Stefan Gerlach , Christian J. Cyron , Johanna Sprenger , Alexander Schlaefer

Optical coherence elastography allows the characterization of the mechanical properties of tissues, and can be performed through estimating local displacement maps from subsequent acquisitions of a sample under different loads. This…

Image and Video Processing · Electrical Eng. & Systems 2021-08-04 Jonathan H. Mason , Yvonne Reinwald , Ying Yang , Sarah Waters , Alicia El Haj , Pierre O. Bagnaninchi

Optical coherence tomography (OCT) is a medical imaging modality that allows us to probe deeper substructures of skin. The state-of-the-art wound care prediction and monitoring methods are based on visual evaluation and focus on surface…

Image and Video Processing · Electrical Eng. & Systems 2023-06-05 Prashant Kumar , Swatantra Dhara , Ayan Gope , Jyotirmoy Chatterjee , Subhamoy Mandal

Objective: To develop an automatic image normalization algorithm for intensity correction of images from breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) acquired by different MRI scanners with various imaging…

Computer Vision and Pattern Recognition · Computer Science 2018-07-09 Jun Zhang , Ashirbani Saha , Brian J. Soher , Maciej A. Mazurowski

It is known that changes in the mechanical properties of tissues are associated with the onset and progression of certain diseases. Ultrasound elastography is a technique to characterize tissue stiffness using ultrasound imaging either by…

Image and Video Processing · Electrical Eng. & Systems 2020-11-22 Hongliang Li , Manish Bhatt , Zhen Qu , Shiming Zhang , Martin C. Hartel , Ali Khademhosseini , Guy Cloutier
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