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Here we characterized an information measure for cell polarity that applies to non-motile cells responding to a chemical gradient. The central idea is that polarization represents information about the direction of the gradient. We applied…

Cell Behavior · Quantitative Biology 2025-04-14 Tau-Mu Yi

Diagnostic tests play a crucial role in medical care. Thus any new diagnostic tests must undergo a thorough evaluation. New diagnostic tests are evaluated in comparison with the respective gold standard tests. The performance of binary…

Applications · Statistics 2025-09-17 Wan Nor Arifin , Umi Kalsom Yusof

In diagnostic studies, researchers frequently encounter imperfect reference standards with some misclassified labels. Treating these as gold standards can bias receiver operating characteristic (ROC) curve analysis. To address this issue,…

Methodology · Statistics 2025-02-13 Yifan Sun , Peijun Sang , Qinglong Tian , Pengfei Li

In pandemics or epidemics, public health authorities need to rapidly test a large number of individuals, both to determine the line of treatment as well as to know the spread of infection to plan containment, mitigation and future…

Other Quantitative Biology · Quantitative Biology 2020-03-31 Tarun Jain , Bijendra Nath Jain

Group testing enables the identification of a small subset of defective items within a larger population by performing tests on pools of items rather than on each item individually. Over the years, it has not only attracted attention from…

Information Theory · Computer Science 2026-01-13 Manuel Franco-Vivo

The corona virus disease 2019 (COVID-19) caused by the novel corona virus has an exponential rate of infection. COVID-19 is particularly notorious as the onset of symptoms in infected patients are usually delayed and there exists a large…

Methodology · Statistics 2020-04-16 Lakshmi N. Theagarajan

We present a parameter estimation technique based on performing joint measurements of a weak interaction away from the weak-value-amplification approximation. Two detectors are used to collect full statistics of the correlations between two…

Quantum Physics · Physics 2016-03-11 Julián Martínez-Rincón , Wei-Tao Liu , Gerardo I. Viza , John C. Howell

Adapting pre-trained models to new tasks can exhibit varying effectiveness across datasets. Visual prompting, a state-of-the-art parameter-efficient transfer learning method, can significantly improve the performance of out-of-distribution…

Computer Vision and Pattern Recognition · Computer Science 2024-09-05 Hsi-Ai Tsao , Lei Hsiung , Pin-Yu Chen , Tsung-Yi Ho

The phase locking value (PLV) is a widely used measure to detect phase connectivity. Main drawbacks of the standard PLV are it can be sensitive to noisy observations and does not provide uncertainty measures under finite samples. To…

Methodology · Statistics 2025-09-09 Shonosuke Sugasawa , Takeru Matsuda , Tomoyuki Nagakawa

Labeling patients in electronic health records with respect to their statuses of having a disease or condition, i.e. case or control statuses, has increasingly relied on prediction models using high-dimensional variables derived from…

Methodology · Statistics 2021-10-14 Zijian Guo , Prabrisha Rakshit , Daniel S. Herman , Jinbo Chen

Pooling specimens, a well-accepted sampling strategy in biomedical research, can be applied to reduce the cost of studying biomarkers. Even if the cost of a single assay is not a major restriction in evaluating biomarkers, pooling can be a…

Applications · Statistics 2012-03-01 Enrique F. Schisterman , Albert Vexler , Aijun Ye , Neil J. Perkins

Linear principal component analysis (PCA) can be extended to a nonlinear PCA by using artificial neural networks. But the benefit of curved components requires a careful control of the model complexity. Moreover, standard techniques for…

Machine Learning · Computer Science 2012-04-04 Matthias Scholz

Existing Partial Label Learning (PLL) methods posit that training and test data adhere to the same distribution, a premise that frequently does not hold in practical application where Out-of-Distribution (OOD) objects are present. We…

Computer Vision and Pattern Recognition · Computer Science 2025-03-13 Jintao Huang , Yiu-Ming Cheung , Chi-Man Vong

Viral load (VL) in the respiratory tract is the leading proxy for assessing infectiousness potential. Understanding the dynamics of disease-related VL within the host is very important and help to determine different policy and health…

Applications · Statistics 2023-08-21 Yonatan Woodbridge , Micha Mandel , Yair Goldberg , Amit Huppert

A Pulse-Compression Probing (PCP) method is applied in time-domain to identify an equivalent circuit model of a distribution network as seen from the transmission grid. A Pseudo-Random Binary Pulse Train (PRBPT) is injected as a voltage…

Systems and Control · Electrical Eng. & Systems 2023-06-05 Nicholas Piaquadio , N. Eva Wu , Morteza Sarailoo , Jianzhuang Huang

The propensity score is widely used for causal inference in observational studies, but common parametric estimators can produce biased and inefficient effect estimates when model assumptions are violated. Nonparametric approaches reduce…

Methodology · Statistics 2026-04-09 Maosen Peng , Yan Li , Chong Wu , Liang Li

Pooled testing is widely used for screening for viral or bacterial infections with low prevalence when individual testing is not cost-efficient. Pooled testing with qualitative assays that give binary results has been well-studied. However,…

Methodology · Statistics 2020-11-03 Tao Liu , Joseph W Hogan , Wanning Su , Yizhen Xu , Michael J Daniels , Kantor Rami

We study adaptive pooling under predictive heterogeneity in high-dimensional multivariate time series forecasting, where global models improve statistical efficiency but may fail to capture heterogeneous predictive structure, while naive…

Methodology · Statistics 2026-04-16 Ziling Ma , Ángel López Oriona , Hernando Ombao , Ying Sun

Much recent work on visual recognition aims to scale up learning to massive, noisily-annotated datasets. We address the problem of scaling- up the evaluation of such models to large-scale datasets with noisy labels. Current protocols for…

Computer Vision and Pattern Recognition · Computer Science 2018-07-03 Phuc Nguyen , Deva Ramanan , Charless Fowlkes

We propose two-stage adaptive pooling schemes, 2-STAP and 2-STAMP, for detecting COVID-19 using real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) test kits. Similar to the Tapestry scheme of Ghosh et al., the…

Information Theory · Computer Science 2020-07-07 Anoosheh Heidarzadeh , Krishna R. Narayanan