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Quantum imaging is emerging as a transformative approach for biomedical applications, applying nonclassical properties of light, such as entanglement, squeezing, and quantum correlations, to overcome fundamental limits of conventional…
Dynamic and precise measurement of cerebral blood flow velocity is crucial in neuroscience and the diagnosis of cerebrovascular diseases. Traditional color Doppler ultrasound can only measure the velocity component along the ultrasound…
In recent years nanoscale coherent imaging has emerged as an indispensable imaging modality allowing to surpass the resolution limit given by classical imaging optics. At the same time, attosecond science has experienced enormous progress…
Ultrathin flat meta-optics have shown great promise for holography in recent years. However, most of the reported meta-optical holograms rely on only phase modulation and neglect the amplitude information. Modulation of both amplitude and…
We introduce OCULAR, an innovative hardware and software solution for three-dimensional dynamic image analysis of fine particles. Current state-of-the art instruments for dynamic image analysis are largely limited to two-dimensional…
Optical coherence tomography (OCT) angiography is a well-established in vivo imaging technique to assess the overall vascular morphology of tissues and is an emerging field of research for the assessment of blood flow dynamics and…
This article reviews deep learning applications in biomedical optics with a particular emphasis on image formation. The review is organized by imaging domains within biomedical optics and includes microscopy, fluorescence lifetime imaging,…
Background: Cardiovascular diseases (CVDs) are the leading cause of death globally. The use of artificial intelligence (AI) methods - in particular, deep learning (DL) - has been on the rise lately for the analysis of different CVD-related…
Dynamic speckle imaging, typically used in laser-illuminated surface diagnostics, has proven valuable for assessing biological activity. In this work, we demonstrate its feasibility in an endoscopic context using a disposable bronchoscope.…
Autonomous robotic surgery has seen significant progression over the last decade with the aims of reducing surgeon fatigue, improving procedural consistency, and perhaps one day take over surgery itself. However, automation has not been…
Diabetic Retinopathy is a medical condition where the retina is damaged because fluid leaks from blood vessels into the retina. The presence of hemorrhages in the retina is the earliest symptom of diabetic retinopathy. The number and shape…
The field of visual and physiological optics is undergoing continuous significant advancements, driven by a deeper understanding of the human visual system and the development of cutting-edge optical technologies. This Roadmap, authored by…
As a non-invasive imaging modality, optical coherence tomography (OCT) can provide micrometer-resolution 3D images of retinal structures. Therefore it is commonly used in the diagnosis of retinal diseases associated with edema in and under…
Automatic blood vessel segmentation from retinal images plays an important role in the diagnosis of many systemic and eye diseases, including retinopathy of prematurity. Current state-of-the-art research in blood vessel segmentation from…
rPPG (Remote photoplethysmography) is a technology that measures and analyzes BVP (Blood Volume Pulse) by using the light absorption characteristics of hemoglobin captured through a camera. Analyzing the measured BVP can derive various…
An image-based technique for measuring the complex field in the pupil of an imaging system is presented. Two point source images, one with a small modification introduced in the pupil, are combined using a simple and non-iterative…
Glaucoma is the leading cause of irreversible but preventable blindness in the world. Its major treatable risk factor is the intra-ocular pressure, although other biomarkers are being explored to improve the understanding of the…
Integrating optical diffraction tomography with imaging flow cytometry enables label-free quantifications of the three-dimensional (3D) morphology and hemoglobin content of red blood cells (RBCs) in their natural form. Self-rotation of RBCs…
Cardiopulmonary resuscitation (CPR) is one of the essential tools to ensure oxygen supply during cardiac arrest. However, the precise effects of chest compression are not quantifiable to this day. This often results in a low quality of…
Optical coherence tomography (OCT) uses low-coherence reflectometry to obtain cross-sectional images of inhomogeneous media, such as biological tissue. OCT is particularly useful in the biomedical ea, since the imaging can be performed…