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Deep neural networks for medical image segmentation are often overconfident, compromising both reliability and clinical utility. In this work, we propose differentiable formulations of marginal L1 Average Calibration Error (mL1-ACE) as an…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Theodore Barfoot , Luis C. Garcia-Peraza-Herrera , Samet Akcay , Ben Glocker , Tom Vercauteren

The Dice similarity coefficient (DSC) is both a widely used metric and loss function for biomedical image segmentation due to its robustness to class imbalance. However, it is well known that the DSC loss is poorly calibrated, resulting in…

Image and Video Processing · Electrical Eng. & Systems 2022-11-02 Michael Yeung , Leonardo Rundo , Yang Nan , Evis Sala , Carola-Bibiane Schönlieb , Guang Yang

Medical image segmentation is fundamental for computer-aided diagnostics, providing accurate delineation of anatomical structures and pathological regions. While common metrics such as Accuracy, DSC, IoU, and HD primarily quantify spatial…

Image and Video Processing · Electrical Eng. & Systems 2025-06-16 Wenhao Liang , Wei Zhang , Lin Yue , Miao Xu , Olaf Maennel , Weitong Chen

Neural networks for automated image segmentation are typically trained to achieve maximum accuracy, while less attention has been given to the calibration of their confidence scores. However, well-calibrated confidence scores provide…

Image and Video Processing · Electrical Eng. & Systems 2020-10-28 Axel-Jan Rousseau , Thijs Becker , Jeroen Bertels , Matthew B. Blaschko , Dirk Valkenborg

We address the problem of network calibration adjusting miscalibrated confidences of deep neural networks. Many approaches to network calibration adopt a regularization-based method that exploits a regularization term to smooth the…

Computer Vision and Pattern Recognition · Computer Science 2023-08-25 Hyekang Park , Jongyoun Noh , Youngmin Oh , Donghyeon Baek , Bumsub Ham

Precise lens structure segmentation is essential for the design of intraocular lenses (IOLs) in cataract surgery. Existing deep segmentation networks typically weight all pixels equally under cross-entropy (CE) loss, overlooking the fact…

Computer Vision and Pattern Recognition · Computer Science 2025-08-13 Zunjie Xiao , Xiao Wu , Tianhang Liu , Lingxi Hu , Yinling Zhang , Xiaoqing Zhang , Risa Higashita , Jiang Liu

Fully convolutional neural networks (FCNs), and in particular U-Nets, have achieved state-of-the-art results in semantic segmentation for numerous medical imaging applications. Moreover, batch normalization and Dice loss have been used…

Image and Video Processing · Electrical Eng. & Systems 2020-07-06 Alireza Mehrtash , William M. Wells , Clare M. Tempany , Purang Abolmaesumi , Tina Kapur

Recent works have shown that deep neural networks can achieve super-human performance in a wide range of image classification tasks in the medical imaging domain. However, these works have primarily focused on classification accuracy,…

Computer Vision and Pattern Recognition · Computer Science 2020-09-10 Gongbo Liang , Yu Zhang , Xiaoqin Wang , Nathan Jacobs

Automatic segmentation methods are an important advancement in medical image analysis. Machine learning techniques, and deep neural networks in particular, are the state-of-the-art for most medical image segmentation tasks. Issues with…

Image and Video Processing · Electrical Eng. & Systems 2021-11-25 Michael Yeung , Evis Sala , Carola-Bibiane Schönlieb , Leonardo Rundo

Probabilistic classifiers output confidence scores along with their predictions, and these confidence scores should be calibrated, i.e., they should reflect the reliability of the prediction. Confidence scores that minimize standard metrics…

This paper proposes a new metric to measure the calibration error of probabilistic binary classifiers, called test-based calibration error (TCE). TCE incorporates a novel loss function based on a statistical test to examine the extent to…

Machine Learning · Statistics 2023-06-27 Takuo Matsubara , Niek Tax , Richard Mudd , Ido Guy

We propose two novel loss functions, Multiplicative Loss and Confidence-Adaptive Multiplicative Loss, for semantic segmentation in medical and cellular images. Although Cross Entropy and Dice Loss are widely used, their additive combination…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Yuto Yokoi , Kazuhiro Hotta

Image segmentation is a fundamental topic in image processing and has been studied for many decades. Deep learning-based supervised segmentation models have achieved state-of-the-art performance but most of them are limited by using…

Image and Video Processing · Electrical Eng. & Systems 2020-11-03 Xu Chen , Xiangde Luo , Yitian Zhao , Shaoting Zhang , Guotai Wang , Yalin Zheng

Semantic segmentation is an essential component of medical image analysis research, with recent deep learning algorithms offering out-of-the-box applicability across diverse datasets. Despite these advancements, segmentation failures remain…

Computer Vision and Pattern Recognition · Computer Science 2024-10-23 Maximilian Zenk , David Zimmerer , Fabian Isensee , Jeremias Traub , Tobias Norajitra , Paul F. Jäger , Klaus Maier-Hein

Class imbalance and the difficulty imbalance are the two types of data imbalance that affect the performance of neural networks in medical segmentation tasks. In class imbalance the loss is dominated by the majority classes and in…

Image and Video Processing · Electrical Eng. & Systems 2025-06-23 Seyed Mohsen Hosseini

Despite the superior performance of Deep Learning (DL) on numerous segmentation tasks, the DL-based approaches are notoriously overconfident about their prediction with highly polarized label probability. This is often not desirable for…

Image and Video Processing · Electrical Eng. & Systems 2021-12-14 Sungmin Hong , Anna K. Bonkhoff , Andrew Hoopes , Martin Bretzner , Markus D. Schirmer , Anne-Katrin Giese , Adrian V. Dalca , Polina Golland , Natalia S. Rost

Medical image segmentation annotations exhibit variations among experts due to the ambiguous boundaries of segmented objects and backgrounds in medical images. Although using multiple annotations for each image in the fully-supervised has…

Computer Vision and Pattern Recognition · Computer Science 2023-11-20 Shuai Wang , Tengjin Weng , Jingyi Wang , Yang Shen , Zhidong Zhao , Yixiu Liu , Pengfei Jiao , Zhiming Cheng , Yaqi Wang

Image segmentation, the process of dividing images into meaningful regions, is critical in medical applications for accurate diagnosis, treatment planning, and disease monitoring. Although manual segmentation by healthcare professionals…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Salma J. Ahmed , Emad A. Mohammed , Azam Asilian Bidgoli

Annotating medical images demands significant time and expertise, often requiring pathologists to invest hundreds of hours in labeling mammary epithelial nuclei datasets. We address this critical challenge by achieving 95.5% Dice score…

Artificial Intelligence · Computer Science 2025-12-03 Varun Kumar Dasoju , Qingsu Cheng , Zeyun Yu

Deep-learning has proved in recent years to be a powerful tool for image analysis and is now widely used to segment both 2D and 3D medical images. Deep-learning segmentation frameworks rely not only on the choice of network architecture but…

Computer Vision and Pattern Recognition · Computer Science 2017-09-19 Carole H Sudre , Wenqi Li , Tom Vercauteren , Sébastien Ourselin , M. Jorge Cardoso
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