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Diffusion-weighted MRI is the forerunner of the rapidly developed microstructural MRI aimed at in vivo evaluation of the cellular tissue architecture. This brief review focuses on the spatiotemporal scales of the microstructure that are…

Medical Physics · Physics 2020-08-14 Valerij G. Kiselev

Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system, characterized by the appearance of focal lesions in the white and gray matter that topographically correlate with an individual…

Computer Vision and Pattern Recognition · Computer Science 2022-01-31 Yang Ma , Chaoyi Zhang , Mariano Cabezas , Yang Song , Zihao Tang , Dongnan Liu , Weidong Cai , Michael Barnett , Chenyu Wang

Diffusion MRI (dMRI) is a valuable tool in the assessment of tissue microstructure. By fitting a model to the dMRI signal it is possible to derive various quantitative features. Several of the most popular dMRI signal models are expansions…

To synthesize diffusion MR measurements from Monte-Carlo simulation using tissue models with sizes comparable to those of scan voxels. Larger regions enable restricting structures to be modeled in greater detail and improve accuracy and…

Computational Physics · Physics 2017-01-16 Matt G Hall , Gemma Nedjati-Gilani , Daniel C Alexander

Magnetic resonance imaging (MRI) is a vital diagnostic tool, but its inherently long acquisition times reduce clinical efficiency and patient comfort. Recent advancements in deep learning, particularly diffusion models, have improved…

Image and Video Processing · Electrical Eng. & Systems 2026-04-28 Yuxuan Zhang , Jinkui Hao , Bo Zhou

Structural magnetic resonance imaging (MRI) can be used to detect lesions in the brains of multiple sclerosis (MS) patients. The formation of these lesions is a complex process involving inflammation, tissue damage, and tissue repair, all…

Accurate segmentation of brain tumors in MRI scans is essential for reliable clinical diagnosis and effective treatment planning. Recently, diffusion models have demonstrated remarkable effectiveness in image generation and segmentation…

Image and Video Processing · Electrical Eng. & Systems 2025-07-31 Sara Yavari , Rahul Nitin Pandya , Jacob Furst

Magnetic resonance imaging technique known as DWI (diffusion-weighted imaging) allows measurement of water diffusivity on a pixel basis for evaluating pathology throughout the body and is now routinely incorporated into many body MRI…

Medical Physics · Physics 2016-11-28 Andrea Barucci , Roberto Carpi , Marco Esposito , Maristella Olmastroni , Giovanna Zatelli

Accurate segmentation of ischemic stroke lesions from diffusion magnetic resonance imaging (MRI) is essential for clinical decision-making and outcome assessment. Diffusion-Weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC)…

Image and Video Processing · Electrical Eng. & Systems 2025-12-24 Muhammad Usman , Azka Rehman , Muhammad Mutti Ur Rehman , Abd Ur Rehman , Muhammad Umar Farooq

This study introduces a diffusion-based framework for robust and accurate segmenton of vertebrae, intervertebral discs (IVDs), and spinal canal from Magnetic Resonance Imaging~(MRI) scans of patients with low back pain (LBP), regardless of…

Image and Video Processing · Electrical Eng. & Systems 2024-11-20 Maria Monzon , Thomas Iff , Ender Konukoglu , Catherine R. Jutzeler

Deep learning-based 3D imaging, in particular magnetic resonance imaging (MRI), is challenging because of limited availability of 3D training data. Therefore, 2D diffusion models trained on 2D slices are starting to be leveraged for 3D MRI…

Computer Vision and Pattern Recognition · Computer Science 2024-12-25 Anselm Krainovic , Stefan Ruschke , Reinhard Heckel

Diffusion magnetic resonance imaging (diffusion MRI) is a non-invasive microstructure assessment technique. Scalar measures, such as FA (fractional anisotropy) and MD (mean diffusivity), quantifying micro-structural tissue properties can be…

Computer Vision and Pattern Recognition · Computer Science 2019-07-23 Xuan Gu , Hans Knutsson , Markus Nilsson , Anders Eklund

Water diffusion gives rise to micron-scale sensitivity of diffusion MRI (dMRI) to cellular-level tissue structure. Precision medicine and quantitative imaging depend on uncovering the information content of dMRI and establishing its…

Medical Physics · Physics 2026-02-03 Santiago Coelho , Jenny Chen , Filip Szczepankiewicz , Els Fieremans , Dmitry S. Novikov

Diffusion-based inverse problem solvers (DIS) have recently shown outstanding performance in compressed-sensing parallel MRI reconstruction by combining diffusion priors with physical measurement models. However, they typically rely on…

Image and Video Processing · Electrical Eng. & Systems 2025-09-24 Tingjun Liu , Chicago Y. Park , Yuyang Hu , Hongyu An , Ulugbek S. Kamilov

Deep learning approaches for diffusion MRI have so far focused primarily on voxel-based segmentation of lesions or white-matter fiber tracts. A drawback of representing tracts as volumetric labels, rather than sets of streamlines, is that…

Image and Video Processing · Electrical Eng. & Systems 2020-09-10 Christian Ewert , David Kügler , Anastasia Yendiki , Martin Reuter

Multi-contrast magnetic resonance imaging (MRI) is the most common management tool used to characterize neurological disorders based on brain tissue contrasts. However, acquiring high-resolution MRI scans is time-consuming and infeasible…

Image and Video Processing · Electrical Eng. & Systems 2023-06-08 Ye Mao , Lan Jiang , Xi Chen , Chao Li

Cortical thickness measurements from magnetic resonance imaging, an important biomarker in many neurodegenerative and neurological disorders, are derived by many tools from an initial voxel-wise tissue segmentation. White matter (WM)…

Image and Video Processing · Electrical Eng. & Systems 2025-03-27 Vinzenz Uhr , Ivan Diaz , Christian Rummel , Richard McKinley

Monte-Carlo Diffusion Simulations (MCDS) have been used extensively as a ground truth tool for the validation of microstructure models for Diffusion-Weighted MRI. However, methodological pitfalls in the design of the biomimicking…

Magnetic Resonance Imaging (MRI) is a powerful, non-invasive diagnostic tool; however, its clinical applicability is constrained by prolonged acquisition times. Whilst present deep learning-based approaches have demonstrated potential in…

Image and Video Processing · Electrical Eng. & Systems 2024-09-24 Anurag Malyala , Zhenlin Zhang , Chengyan Wang , Chen Qin

This study introduces a novel approach for image reconstruction based on a diffusion model conditioned on the native data domain. Our method is applied to multi-coil MRI and quantitative MRI reconstruction, leveraging the domain-conditioned…

Machine Learning · Computer Science 2023-09-06 Wanyu Bian , Albert Jang , Fang Liu