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Purpose: Recent developments in computational pathology have been driven by advances in Vision Foundation Models, particularly the Segment Anything Model (SAM). This model facilitates nuclei segmentation through two primary methods:…

Computer Vision and Pattern Recognition · Computer Science 2025-08-22 Xueyuan Li , Can Cui , Ruining Deng , Yucheng Tang , Quan Liu , Tianyuan Yao , Shunxing Bao , Naweed Chowdhury , Haichun Yang , Yuankai Huo

We introduce CellSegmenter, a structured deep generative model and an amortized inference framework for unsupervised representation learning and instance segmentation tasks. The proposed inference algorithm is convolutional and…

Computer Vision and Pattern Recognition · Computer Science 2020-11-26 Luca D'Alessio , Mehrtash Babadi

The significant morphological and distributional variability among subcellular components poses a long-standing challenge for learning-based organelle segmentation models, significantly increasing the risk of biased feature learning.…

Computer Vision and Pattern Recognition · Computer Science 2025-07-24 Bo Fang , Jianan Fan , Dongnan Liu , Hang Chang , Gerald J. Shami , Filip Braet , Weidong Cai

Deep learning has achieved impressive results in nuclei segmentation, but the massive requirement for pixel-wise labels remains a significant challenge. To alleviate the annotation burden, existing methods generate pseudo masks for model…

Computer Vision and Pattern Recognition · Computer Science 2024-06-25 Ziyue Wang , Ye Zhang , Yifeng Wang , Linghan Cai , Yongbing Zhang

AI-assisted nuclei segmentation in histopathological images is a crucial task in the diagnosis and treatment of cancer diseases. It decreases the time required to manually screen microscopic tissue images and can resolve the conflict…

Image and Video Processing · Electrical Eng. & Systems 2023-11-21 Hesham Ali , Idriss Tondji , Mennatullah Siam

In this paper, we present a novel method to automatically classify medical images that learns and leverages weak causal signals in the image. Our framework consists of a convolutional neural network backbone and a causality-extractor module…

Computer Vision and Pattern Recognition · Computer Science 2023-09-20 Gianluca Carloni , Eva Pachetti , Sara Colantonio

We propose a 3D convolutional neural network to simultaneously segment and detect cell nuclei in confocal microscopy images. Mirroring the co-dependency of these tasks, our proposed model consists of two serial components: the first part…

Image and Video Processing · Electrical Eng. & Systems 2018-09-07 Sundaresh Ram , Vicky T. Nguyen , Kirsten H. Limesand , Mert R. Sabuncu

Modern deep learning models excel at pattern recognition but remain fundamentally limited by their reliance on spurious correlations, leading to poor generalization and a demand for massive datasets. We argue that a key ingredient for…

Machine Learning · Computer Science 2025-09-17 Mohamed Zayaan S

Deep learning models for medical image segmentation suffer significant performance drops due to distribution shifts, but the causal mechanisms behind these drops remain poorly understood. We extend causal attribution frameworks to…

Image and Video Processing · Electrical Eng. & Systems 2025-12-11 Pedro M. Gordaliza , Nataliia Molchanova , Jaume Banus , Thomas Sanchez , Meritxell Bach Cuadra

Understanding the causal effects of organ-specific features from medical imaging on clinical outcomes is essential for biomedical research and patient care. We propose a novel Functional Linear Structural Equation Model (FLSEM) to capture…

Methodology · Statistics 2026-01-29 Ting Li , Ethan Fan , Tengfei Li , Hongtu Zhu

Lesion segmentation is an important problem in computer-assisted diagnosis that remains challenging due to the prevalence of low contrast, irregular boundaries that are unamenable to shape priors. We introduce Deep Active Lesion…

Image and Video Processing · Electrical Eng. & Systems 2020-09-01 Ali Hatamizadeh , Assaf Hoogi , Debleena Sengupta , Wuyue Lu , Brian Wilcox , Daniel Rubin , Demetri Terzopoulos

We present SAM, a biologically-plausible selective attention-driven modulation approach to enhance classification models in a continual learning setting. Inspired by neurophysiological evidence that the primary visual cortex does not…

Computer Vision and Pattern Recognition · Computer Science 2024-04-01 Giovanni Bellitto , Federica Proietto Salanitri , Matteo Pennisi , Matteo Boschini , Angelo Porrello , Simone Calderara , Simone Palazzo , Concetto Spampinato

Deep neural networks have enabled major progresses in semantic segmentation. However, even the most advanced neural architectures suffer from important limitations. First, they are vulnerable to catastrophic forgetting, i.e. they perform…

Computer Vision and Pattern Recognition · Computer Science 2022-02-01 Fabio Cermelli , Massimiliano Mancini , Samuel Rota Buló , Elisa Ricci , Barbara Caputo

Medical image segmentation methods generally assume that the process from medical image to segmentation is unbiased, and use neural networks to establish conditional probability models to complete the segmentation task. This assumption does…

Image and Video Processing · Electrical Eng. & Systems 2025-05-29 Ruiguo Yu , Yiyang Zhang , Yuan Tian , Yujie Diao , Di Jin , Witold Pedrycz

Deep learning (DL) has recently drawn much attention in image analysis, natural language process, and high-dimensional medical data analysis. Under the causal direct acyclic graph (DAG) interpretation, the input variables without incoming…

Applications · Statistics 2022-03-22 Jong-Hyeon Jeong , Yichen Jia

Aggregating features in terms of different convolutional blocks or contextual embeddings has been proven to be an effective way to strengthen feature representations for semantic segmentation. However, most of the current popular network…

Computer Vision and Pattern Recognition · Computer Science 2021-03-03 Zilong Huang , Yunchao Wei , Xinggang Wang , Wenyu Liu , Thomas S. Huang , Humphrey Shi

Accurate medical image segmentation is essential for diagnosis and treatment planning of diseases. Convolutional Neural Networks (CNNs) have achieved state-of-the-art performance for automatic medical image segmentation. However, they are…

Image and Video Processing · Electrical Eng. & Systems 2020-11-05 Ran Gu , Guotai Wang , Tao Song , Rui Huang , Michael Aertsen , Jan Deprest , Sébastien Ourselin , Tom Vercauteren , Shaoting Zhang

Cell segmentation is a fundamental task in microscopy image analysis. Several foundation models for cell segmentation have been introduced, virtually all of them are extensions of Segment Anything Model (SAM), improving it for microscopy…

Computer Vision and Pattern Recognition · Computer Science 2026-03-19 Anwai Archit , Constantin Pape

Deep neural networks have significantly improved the performance of low-level vision tasks but also increased the difficulty of interpretability. A deep understanding of deep models is beneficial for both network design and practical…

Computer Vision and Pattern Recognition · Computer Science 2025-04-01 Jinfan Hu , Jinjin Gu , Shiyao Yu , Fanghua Yu , Zheyuan Li , Zhiyuan You , Chaochao Lu , Chao Dong

Vision-Language Models (VLMs), such as CLIP, have demonstrated remarkable zero-shot capabilities in various computer vision tasks. However, their application to medical imaging remains challenging due to the high variability and complexity…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Xusheng Liang , Lihua Zhou , Nianxin Li , Miao Xu , Ziyang Song , Dong Yi , Jinlin Wu , Jiawei Ma , Hongbin Liu , Zhen Lei , Jiebo Luo