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Modern medical image registration approaches predict deformations using deep networks. These approaches achieve state-of-the-art (SOTA) registration accuracy and are generally fast. However, deep learning (DL) approaches are, in contrast to…

Learning-based medical image registration has matched the accuracy of conventional methods while offering superior computational efficiency. However, existing approaches suffer from poor generalization across diverse clinical scenarios,…

Computer Vision and Pattern Recognition · Computer Science 2026-05-25 Zi Li , Jianpeng Zhang , Tai Ma , Tony C. W. Mok , Yan-Jie Zhou , Zeli Chen , Xianghua Ye , Le Lu , Cheng Chen , Dakai Jin

Foundational models are trained on extensive datasets to capture the general trends of a domain. However, in medical imaging, the scarcity of data makes pre-training for every domain, modality, or task challenging. Continual learning offers…

Image and Video Processing · Electrical Eng. & Systems 2025-08-20 Mohammad Areeb Qazi , Munachiso S Nwadike , Ibrahim Almakky , Mohammad Yaqub , Numan Saeed

We present an approach to learning regular spatial transformations between image pairs in the context of medical image registration. Contrary to optimization-based registration techniques and many modern learning-based methods, we do not…

Non-rigid registration is a necessary but challenging task in medical imaging studies. Recently, unsupervised registration models have shown good performance, but they often require a large-scale training dataset and long training times.…

Computer Vision and Pattern Recognition · Computer Science 2021-04-22 Heejung Park , Gyeong Min Lee , Soopil Kim , Ga Hyung Ryu , Areum Jeong , Sang Hyun Park , Min Sagong

We present a fast learning-based algorithm for deformable, pairwise 3D medical image registration. Current registration methods optimize an objective function independently for each pair of images, which can be time-consuming for large…

Computer Vision and Pattern Recognition · Computer Science 2019-03-14 Guha Balakrishnan , Amy Zhao , Mert R. Sabuncu , John Guttag , Adrian V. Dalca

Medical foundation models show promise to learn broadly generalizable features from large, diverse datasets. This could be the base for reliable cross-modality generalization and rapid adaptation to new, task-specific goals, with only a few…

Multimodal image registration is a challenging but essential step for numerous image-guided procedures. Most registration algorithms rely on the computation of complex, frequently non-differentiable similarity metrics to deal with the…

Computer Vision and Pattern Recognition · Computer Science 2023-07-20 Matteo Ronchetti , Wolfgang Wein , Nassir Navab , Oliver Zettinig , Raphael Prevost

Deformable medical image registration is an essential task in computer-assisted interventions. This problem is particularly relevant to oncological treatments, where precise image alignment is necessary for tracking tumor growth, assessing…

Computer Vision and Pattern Recognition · Computer Science 2025-06-04 Stefano Fogarollo , Gregor Laimer , Reto Bale , Matthias Harders

Deep learning technologies have dramatically reshaped the field of medical image registration over the past decade. The initial developments, such as regression-based and U-Net-based networks, established the foundation for deep learning in…

Image and Video Processing · Electrical Eng. & Systems 2024-11-04 Junyu Chen , Yihao Liu , Shuwen Wei , Zhangxing Bian , Shalini Subramanian , Aaron Carass , Jerry L. Prince , Yong Du

Image registration is the process of bringing different images into a common coordinate system - a technique widely used in various applications of computer vision, such as remote sensing, image retrieval, and, most commonly, medical…

Foundation models, pre-trained on large image datasets and capable of capturing rich feature representations, have recently shown potential for zero-shot image registration. However, their performance has mostly been tested in the context…

Image and Video Processing · Electrical Eng. & Systems 2025-08-12 Hanxue Gu , Yaqian Chen , Nicholas Konz , Qihang Li , Maciej A. Mazurowski

Deep learning has revolutionized medical image registration by achieving unprecedented speeds, yet its clinical application is hindered by a limited ability to generalize beyond the training domain, a critical weakness given the typically…

Computer Vision and Pattern Recognition · Computer Science 2026-02-02 Fengting Zhang , Yue He , Qinghao Liu , Yaonan Wang , Xiang Chen , Hang Zhang

Image registration is fundamental in medical imaging applications, such as disease progression analysis or radiation therapy planning. The primary objective of image registration is to precisely capture the deformation between two or more…

Image and Video Processing · Electrical Eng. & Systems 2024-12-23 Anna Reithmeir , Veronika Spieker , Vasiliki Sideri-Lampretsa , Daniel Rueckert , Julia A. Schnabel , Veronika A. Zimmer

Recent advances in deep learning-based medical image registration have shown that training deep neural networks~(DNNs) does not necessarily require medical images. Previous work showed that DNNs trained on randomly generated images with…

Computer Vision and Pattern Recognition · Computer Science 2025-06-02 Junyu Chen , Shuwen Wei , Yihao Liu , Aaron Carass , Yong Du

Image registration techniques usually assume that the images to be registered are of a certain type (e.g. single- vs. multi-modal, 2D vs. 3D, rigid vs. deformable) and there lacks a general method that can work for data under all…

Image and Video Processing · Electrical Eng. & Systems 2025-01-28 Quang Luong Nhat Nguyen , Ruiming Cao , Laura Waller

Deformable registration is a fundamental task in medical image processing, aiming to achieve precise alignment by establishing nonlinear correspondences between images. Traditional methods offer good adaptability and interpretability but…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Jing Hu , Kaiwei Yu , Hongjiang Xian , Shu Hu , Xin Wang

During raw-data acquisition in CT imaging, diverse factors can degrade the collected sinograms, with undersampling and noise leading to severe artifacts and noise in reconstructed images and compromising diagnostic accuracy. Conventional…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Xingyu Ai , Shaoyu Wang , Zhiyuan Jia , Ao Xu , Hongming Shan , Jianhua Ma , Qiegen Liu

Deformable registration consists of finding the best dense correspondence between two different images. Many algorithms have been published, but the clinical application was made difficult by the high calculation time needed to solve the…

Computer Vision and Pattern Recognition · Computer Science 2021-11-25 Théo Estienne , Maria Vakalopoulou , Enzo Battistella , Theophraste Henry , Marvin Lerousseau , Amaury Leroy , Nikos Paragios , Eric Deutsch

The integration of AI-assisted biomedical image analysis into clinical practice demands AI-generated findings that are not only accurate but also interpretable to clinicians. However, existing biomedical AI models generally lack the ability…

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