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Understanding 3D medical image volumes is critical in the medical field, yet existing 3D medical convolution and transformer-based self-supervised learning (SSL) methods often lack deep semantic comprehension. Recent advancements in…

Computer Vision and Pattern Recognition · Computer Science 2025-09-12 Qiuhui Chen , Xuancheng Yao , Huping Ye , Yi Hong

3D medical image analysis is of great importance in disease diagnosis and treatment. Recently, multimodal large language models (MLLMs) have exhibited robust perceptual capacity, strong cross-modal alignment, and promising generalizability.…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Yang Yu , Dunyuan Xu , Yaoqian Li , Xiaomeng Li , Jinpeng Li , Pheng-Ann Heng

Medical image analysis is essential to clinical diagnosis and treatment, which is increasingly supported by multi-modal large language models (MLLMs). However, previous research has primarily focused on 2D medical images, leaving 3D images…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Fan Bai , Yuxin Du , Tiejun Huang , Max Q. -H. Meng , Bo Zhao

Vision-language models (VLMs) have shown promise in 2D medical image analysis, but extending them to 3D remains challenging due to the high computational demands of volumetric data and the difficulty of aligning 3D spatial features with…

Computer Vision and Pattern Recognition · Computer Science 2025-12-17 Yu Xin , Gorkem Can Ates , Kuang Gong , Wei Shao

3D medical image analysis is essential for modern healthcare, yet traditional task-specific models are inadequate due to limited generalizability across diverse clinical scenarios. Multimodal large language models (MLLMs) offer a promising…

Computer Vision and Pattern Recognition · Computer Science 2025-10-22 Yiming Shi , Xun Zhu , Kaiwen Wang , Ying Hu , Chenyi Guo , Miao Li , Ji Wu

While 3D visual self-supervised learning (vSSL) shows promising results in capturing visual representations, it overlooks the clinical knowledge from radiology reports. Meanwhile, 3D medical vision-language pre-training (MedVLP) remains…

Computer Vision and Pattern Recognition · Computer Science 2025-02-26 Che Liu , Cheng Ouyang , Yinda Chen , Cesar César Quilodrán-Casas , Lei Ma , Jie Fu , Yike Guo , Anand Shah , Wenjia Bai , Rossella Arcucci

Recent medical vision-language models (VLMs) have shown promise in 2D medical image interpretation. However extending them to 3D medical imaging has been challenging due to computational complexities and data scarcity. Although a few recent…

Image and Video Processing · Electrical Eng. & Systems 2024-12-19 Changsun Lee , Sangjoon Park , Cheong-Il Shin , Woo Hee Choi , Hyun Jeong Park , Jeong Eun Lee , Jong Chul Ye

Multi-modal large language models (MLLMs) have shown promise in advancing healthcare. However, most existing models remain confined to single-image understanding, which greatly limits their applicability in clinical workflows. In practice,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Zhen Chen , Yihang Fu , Gabriel Madera , Mauro Giuffre , Serina Applebaum , Hyunjae Kim , Hua Xu , Qingyu Chen

Multi-modal Large Language Models (MLLMs) exhibit impressive capabilities in 2D tasks, yet encounter challenges in discerning the spatial positions, interrelations, and causal logic in scenes when transitioning from 2D to 3D…

Computer Vision and Pattern Recognition · Computer Science 2025-01-15 Haomiao Xiong , Yunzhi Zhuge , Jiawen Zhu , Lu Zhang , Huchuan Lu

The rapid advancement of Multimodal Large Language Models (MLLMs) has significantly impacted various multimodal tasks. However, these models face challenges in tasks that require spatial understanding within 3D environments. Efforts to…

Computer Vision and Pattern Recognition · Computer Science 2025-03-28 Duo Zheng , Shijia Huang , Liwei Wang

New era has unlocked exciting possibilities for extending Large Language Models (LLMs) to tackle 3D vision-language tasks. However, most existing 3D multimodal LLMs (MLLMs) rely on compressing holistic 3D scene information or segmenting…

Computer Vision and Pattern Recognition · Computer Science 2025-07-23 Xiaoyan Wang , Zeju Li , Yifan Xu , Jiaxing Qi , Zhifei Yang , Ruifei Ma , Xiangde Liu , Chao Zhang

Large Language Models (LLMs), known for their versatility in textual data, are increasingly being explored for their potential to enhance medical image segmentation, a crucial task for accurate diagnostic imaging. This study explores…

Image and Video Processing · Electrical Eng. & Systems 2025-08-20 Gurucharan Marthi Krishna Kumar , Aman Chadha , Janine Mendola , Amir Shmuel

3D spatial understanding is essential in real-world applications such as robotics, autonomous vehicles, virtual reality, and medical imaging. Recently, Large Language Models (LLMs), having demonstrated remarkable success across various…

Computer Vision and Pattern Recognition · Computer Science 2026-03-23 Jirong Zha , Yuxuan Fan , Xiao Yang , Chen Gao , Xinlei Chen

3D medical image analysis is pivotal in numerous clinical applications. However, the scarcity of labeled data and limited generalization capabilities hinder the advancement of AI-empowered models. Radiology reports are easily accessible and…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Xuefeng Ni , Linshan Wu , Jiaxin Zhuang , Qiong Wang , Mingxiang Wu , Varut Vardhanabhuti , Lihai Zhang , Hanyu Gao , Hao Chen

Medical image analysis is essential in modern healthcare. Deep learning has redirected research focus toward complex medical multimodal tasks, including report generation and visual question answering. Traditional task-specific models often…

Computer Vision and Pattern Recognition · Computer Science 2025-09-15 Yiming Shi , Shaoshuai Yang , Xun Zhu , Haoyu Wang , Xiangling Fu , Miao Li , Ji Wu

Multimodal large language models (MLLMs) have achieved impressive performance across various tasks such as image captioning and visual question answer(VQA); however, they often struggle to accurately interpret depth information inherent in…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Hao Yang , Hongbo Zhang , Yanyan Zhao , Bing Qin

Recent advancements in Multimodal Large Language Models (MLLMs) have significantly enhanced performance on 2D visual tasks. However, improving their spatial intelligence remains a challenge. Existing 3D MLLMs always rely on additional 3D or…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Diankun Wu , Fangfu Liu , Yi-Hsin Hung , Yueqi Duan

Recent advances in scene understanding have leveraged multimodal large language models (MLLMs) for 3D reasoning by capitalizing on their strong 2D pretraining. However, the lack of explicit 3D data during MLLM pretraining limits 3D…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Xiaohu Huang , Jingjing Wu , Qunyi Xie , Kai Han

Language Models (LMs) have greatly influenced diverse domains. However, their inherent limitation in comprehending 3D molecular structures has considerably constrained their potential in the biomolecular domain. To bridge this gap, we focus…

Machine Learning · Computer Science 2024-03-19 Sihang Li , Zhiyuan Liu , Yanchen Luo , Xiang Wang , Xiangnan He , Kenji Kawaguchi , Tat-Seng Chua , Qi Tian

Understanding brain disorders is crucial for accurate clinical diagnosis and treatment. Recent advances in Multimodal Large Language Models (MLLMs) offer a promising approach to interpreting medical images with the support of text…

Image and Video Processing · Electrical Eng. & Systems 2025-06-03 Jing Zhang , Xiaowei Yu , Yanjun Lyu , Lu Zhang , Tong Chen , Chao Cao , Yan Zhuang , Minheng Chen , Tianming Liu , Dajiang Zhu
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