Related papers: High throughput spectroscopy of pL droplets
Label-free spectromicroscopy methods offer the capability to examine complex cellular phenomena. Electron and X-ray-based spectromicroscopy methods, though powerful, have been hard to implement with hydrated objects due to the vacuum…
Large-scale microfluidic microsystems with complex three-dimensional (3D) configurations are highly in demand by both fundamental research and industrial application, holding the potentials for fostering a wide range of innovative…
We present an optofluidic sensor based on an elastomeric two-dimensional (2D) grating integrated inside a hemispherical fluid chamber. Laser beam is diffracted before (reflection) and after (transmission) going through the grating and…
We present a high-throughput microfluidic platform capable of quantitating up to 384 biomarkers in 4 distinct samples by immunoassay. The microfluidic device contains 384 unit cells, which can be individually programmed with pairs of…
The miniaturization and integration of electronic circuitry has not only made the enormous increase in performance of semiconductor devices possible but also spawned a myriad of new products and applications ranging from a cellular phone to…
Flows of particles through bottlenecks are ubiquitous in nature and industry, involving both dry granular materials and suspensions. However, practical limitations of conventional experimental setups hinder the full understanding of these…
The ability to use coherent light for material science and applications is directly linked to our ability to measure short optical pulses. While free-space optical methods are well-established, achieving this on a chip would offer the…
Deep learning-based optical flow (DLOF) extracts features in adjacent video frames with deep convolutional neural networks. It uses those features to estimate the inter-frame motions of objects at the pixel level. In this article, we…
Recent advances recognize that the viscoelastic properties of epithelial structures play important roles in biology and disease modeling. However, accessing the viscoelastic properties of multicellular structures in mechanistic or…
This chapter presents an overview of microfluidic devices reported in the literature, used to develop methodologies for nucleation of biomolecules, with crystal size control, and for collecting thermodynamic and kinetic data. Part I is…
Energy transfer between photons and molecules and between neighboring molecules is ubiquitous in living nature, most prominently in photosynthesis. While energy transfer is efficiently utilized by living systems, its adoption to connect…
The study of interactions between biomimetic membranes and micron-sized particles is crucial for understanding various biological processes. Here, we control microparticle spontaneous engulfment by giant lipid vesicles by tuning particle…
Optical techniques are finding widespread use in analytical chemistry for chemical and bio-chemical analysis. During the past decade, there has been an increasing emphasis on miniaturization of chemical analysis systems and naturally this…
Aerobreakup of fluid droplets under the influence of impulsively generated high-speed gas flow using an open-ended shock tube is studied using experiments and numerical simulations. Breakup of mm-sized droplets at high Weber number was…
Infrared (IR) spectroscopy has emerged as a pivotal tool in biomedical diagnostics, offering label-free spectral biomarkers for the detection of numerous diseases, particularly in the fingerprint region. However, the lack of rapid and…
Reliable measurement of droplet/bubble size and velocity distributions in dense flows is desired in a variety of research fields, both for laboratory and industrial use. A new type of single-mode monofiber optical probe manufactured by A2…
In this article we present a new diagnostic approach utilizing flow-cytometry to study compounds of nanoparticle samples in solution by analysis of their scattering patterns retrieved from the cytometric measurements. As a specific…
Optofluidic sensors based on highly dispersive two-dimensional photonic crystal waveguides are theoretically studied. Results show that these structures are strongly sensitive to the refractive index of the infiltrated liquid (nl), which is…
Droplet-based microfluidics turned out to be an efficient and adjustable platform for digital analysis, encapsulation of cells, drug formulation, and polymerase chain reaction. Typically, for most biomedical applications, the handling of…
The simplest microfluidic network (a loop) comprises two parallel channels with a common inlet and a common outlet. Recent studies, that assumed constant cross-section of the channels along their length, have shown that the sequence of…