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Contrast-enhanced magnetic resonance imaging (CE-MRI) is crucial for tumor detection and diagnosis, but the use of gadolinium-based contrast agents (GBCAs) in clinical settings raises safety concerns due to potential health risks. To…

Obtaining manual annotations for large datasets for supervised training of deep learning (DL) models is challenging. The availability of large unlabeled datasets compared to labeled ones motivate the use of self-supervised pretraining to…

Since 2016, deep learning (DL) has advanced tomographic imaging with remarkable successes, especially in low-dose computed tomography (LDCT) imaging. Despite being driven by big data, the LDCT denoising and pure end-to-end reconstruction…

Low fluence illumination sources can facilitate clinical transition of photoacoustic imaging because they are rugged, portable, affordable, and safe. However, these sources also decrease image quality due to their low fluence. Here, we…

Deep neural networks (DNNs) are vulnerable to adversarial noises. Adversarial training is a general and effective strategy to improve DNN robustness (i.e., accuracy on noisy data) against adversarial noises. However, DNN models trained by…

A new development in photoacoustic (PA) imaging has been the use of compact, portable and low-cost laser diodes (LDs), but LD-based PA imaging suffers from low signal intensity recorded by the conventional transducers. A common method to…

Deep Neural Network (DNN)-based image reconstruction, despite many successes, often exhibits uneven fidelity between high and low spatial frequency bands. In this paper we propose the Learning Synthesis by DNN (LS-DNN) approach where two…

Image-to-image translation is an ill-posed problem as unique one-to-one mapping may not exist between the source and target images. Learning-based methods proposed in this context often evaluate the performance on test data that is similar…

Domain Generalization (DG) is essentially a sub-branch of out-of-distribution generalization, which trains models from multiple source domains and generalizes to unseen target domains. Recently, some domain generalization algorithms have…

Deep learning has shown great promise for CT image reconstruction, in particular to enable low dose imaging and integrated diagnostics. These merits, however, stand at great odds with the low availability of diverse image data which are…

Diffusion probabilistic models (DPMs) have become a popular approach to conditional generation, due to their promising results and support for cross-modal synthesis. A key desideratum in conditional synthesis is to achieve high…

Reconstruction of magnetic resonance imaging (MRI) data has been positively affected by deep learning. A key challenge remains: to improve generalisation to distribution shifts between the training and testing data. Most approaches aim to…

Photoacoustic microscopy (PAM) is an emerging imaging method combining light and sound. However, limited by the laser's repetition rate, state-of-the-art high-speed PAM technology often sacrifices spatial sampling density (i.e.,…

Physics-driven deep learning (PD-DL) models have proven to be a powerful approach for improved reconstruction of rapid MRI scans. In order to train these models in scenarios where fully-sampled reference data is unavailable, self-supervised…

Magnetic Resonance Imaging (MRI) is considered the gold standard of medical imaging because of the excellent soft-tissue contrast exhibited in the images reconstructed by the MRI pipeline, which in-turn enables the human radiologist to…

Sparse and noisy images (SNIs), like those in spatial gene expression data, pose significant challenges for effective representation learning and clustering, which are essential for thorough data analysis and interpretation. In response to…

Deep neural network based methods have achieved promising results for CT metal artifact reduction (MAR), most of which use many synthesized paired images for training. As synthesized metal artifacts in CT images may not accurately reflect…

Natural language understanding (NLU) models often rely on dataset biases rather than intended task-relevant features to achieve high performance on specific datasets. As a result, these models perform poorly on datasets outside the training…

A conditional general adversarial network (GAN) is proposed for image deblurring problem. It is tailored for image deblurring instead of just applying GAN on the deblurring problem. Motivated by that, dark channel prior is carefully picked…

Contrastive Analysis (CA) detects anomalies by contrasting patterns unique to a target group (e.g., unhealthy subjects) from those in a background group (e.g., healthy subjects). In the context of brain MRIs, existing CA approaches rely on…