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Contrast-enhanced ultrasound (CEUS) presents distinct advantages in diagnostic echography. Utilizing microbubbles (MBs) as conventional contrast agents enhances vascular visualization and organ perfusion, facilitating real-time,…

Medical Physics · Physics 2024-12-04 Agisilaos Matalliotakis , Martin D. Verweij

Monodisperse microbubble ultrasound contrast agents have been proposed to further increase the signal-to-noise-ratio of contrast enhanced ultrasound imaging. Here, the sensitivity of a polydisperse preclinical agent was compared…

Medical Physics · Physics 2018-06-13 Tim Segers , Pieter Kruizinga , Maarten Kok , Guillaume Lajoinie , Nico de Jong , Michel Versluis

Ultrasound contrast imaging is a specialized imaging technique that applies microbubble contrast agents to traditional medical sonography, providing real-time visualization of blood flow and vessels. Gas-filled microbubbles are injected…

Analysis of PDEs · Mathematics 2024-12-17 Vanja Nikolić , Teresa Rauscher

An ideal contrast-enhanced ultrasound image should display microbubble-induced nonlinearities while avoiding wave propagation nonlinearities. One of the most successful ultrasound pulse sequences to disentangle these nonlinear effects…

Medical Physics · Physics 2024-05-16 A. Matalliotakis , D. Maresca , M. D. Verweij

Transcranial ultrasound imaging is currently limited by attenuation and aberration induced by the skull. First used in contrast-enhanced ultrasound (CEUS), highly echoic microbubbles allowed for the development of novel imaging modalities…

Image and Video Processing · Electrical Eng. & Systems 2025-11-06 Paul Xing , Antoine Malescot , Eric Martineau , Ravi Rungta , Jean Provost

Generation of super-resolution (SR) ultrasound (US) images, created from the successive local-ization of individual microbubbles in the circulation, has enabled the visualization of microvascular structure and flow at a level of detail that…

Image and Video Processing · Electrical Eng. & Systems 2024-06-19 Scott Schoen , Zhigen Zhao , Ashley Alva , Chengwu Huang , Shigao Chen , Costas Arvanitis

In ultrasound imaging, propagation of an acoustic wavefront through heterogeneous media causes phase aberrations that degrade the coherence of the reflected wavefront, leading to reduced image resolution and contrast. Adaptive imaging…

Super-resolution ultrasound (SRUS) imaging through localising and tracking sparse microbubbles has been shown to reveal microvascular structure and flow beyond the wave diffraction limit. Most SRUS studies use standard delay and sum (DAS)…

Wavefront shaping techniques allow waves to be focused on a diffraction-limited target deep inside disordered media. To identify the target position, a guidestar is required that typically emits a frequency-shifted signal. Here we present a…

Applied Physics · Physics 2025-05-13 Antton Goïcoechea , Jakob Hüpfl , Stefan Rotter , François Sarrazin , Matthieu Davy

Resolving arterial flows is essential for understanding cardiovascular pathologies, improving diagnosis, and monitoring patient condition. Ultrasound contrast imaging uses microbubbles to enhance the scattering of the blood pool, allowing…

Photonic devices rarely provide both elaborate spatial control and sharp spectral control over an incoming wavefront. In optical metasurfaces, for example, the localized modes of individual meta-units govern the wavefront shape over a broad…

Optics · Physics 2022-01-27 Stephanie C. Malek , Adam C. Overvig , Andrea Alù , Nanfang Yu

Ultrasound imaging, despite its widespread use in medicine, often suffers from various sources of noise and artifacts that impact the signal-to-noise ratio and overall image quality. Enhancing ultrasound images requires a delicate balance…

Computer Vision and Pattern Recognition · Computer Science 2024-09-18 Yuxin Zhang , Clément Huneau , Jérôme Idier , Diana Mateus

The standard technique used by commercial medical ultrasound systems to form B-mode images is delay and sum (DAS) beamforming. However, DAS often results in limited image resolution and contrast, which are governed by the center frequency…

Information Theory · Computer Science 2018-08-06 Regev Cohen , Yonina C. Eldar

Subharmonics emitted from microbubble-based ultrasound contrast agents (UCA) are considered as a noninvasive indicator for diagnostic applications in medical fields. Contrast ultrasound imaging using the modality of subharmonics could be…

Medical Physics · Physics 2021-04-13 Lang Xia

Ultrasound contrast agents have been recently utilized in therapeutical implementations for targeted delivery of pharmaceutical substances. Radial pulsations of the encapsulated microbubbles under the action of an ultrasound field are…

Soft Condensed Matter · Physics 2018-11-29 Farzan Ghalichi , Sohrab Behnia , Farshad Mottaghi , Mohammad Yahyavi

Contrast-Enhanced Ultra-Sound (CEUS) has become a viable method for non-invasive, dynamic visualization in medical diagnostics, yet Ultrasound Localization Microscopy (ULM) has enabled a revolutionary breakthrough by offering ten times…

Computer Vision and Pattern Recognition · Computer Science 2023-07-19 Christopher Hahne , Raphael Sznitman

The oscillations of ultrasound contrast agents are of particular importance to the understanding of the propagation of acoustic waves in the bubbly liquids (suspensions of ultrasound contrast agents). Acoustic waves propagating in bubbly…

Fluid Dynamics · Physics 2018-10-05 Lang Xia

We analyze mathematically the acoustic imaging modality using bubbles as contrast agents. These bubbles are modeled by mass densities and bulk moduli enjoying contrasting scales. These contrasting scales allow them to resonate at certain…

Analysis of PDEs · Mathematics 2020-04-17 Alexander Dabrowski , Ahcene Ghandriche , Mourad Sini

Imaging the human brain vasculature with high spatial and temporal resolution remains challenging in the clinic today. Transcranial ultrasound is scarcely used for cerebrovascular imaging, due to low sensitivity and strong phase aberrations…

Recently, the investigation of metasurface has been extended to wave control through exploiting nonlinearity. Among all of the ways to achieve tunable metasurfaces with multiplexed performances, nonlinearity is one of the promising choices.…

Applied Physics · Physics 2020-12-02 Mehdi Kiani , Ali Momeni , Majid Tayarani , Can Ding
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