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Functional MRI (fMRI) is crucial for studying brain function and diagnosing neurological disorders. However, existing analysis methods suffer from reproducibility and transferability challenges due to complex preprocessing pipelines and…

With the development of deep learning techniques, supervised learning has achieved performances surpassing those of humans. Researchers have designed numerous corresponding models for different data modalities, achieving excellent results…

Artificial Intelligence · Computer Science 2023-08-29 Qiang Li , Qiuyang Ma , Weizhi Nie , Anan Liu

Self-supervised learning is an efficient pre-training method for medical image analysis. However, current research is mostly confined to specific-modality data pre-training, consuming considerable time and resources without achieving…

Computer Vision and Pattern Recognition · Computer Science 2023-12-01 Yiwen Ye , Yutong Xie , Jianpeng Zhang , Ziyang Chen , Qi Wu , Yong Xia

Single subject prediction of brain disorders from neuroimaging data has gained increasing attention in recent years. Yet, for some heterogeneous disorders such as major depression disorder (MDD) and autism spectrum disorder (ASD), the…

Machine Learning · Computer Science 2022-06-08 Ahmed El Gazzar , Rajat Mani Thomas , Guido Van Wingen

While the shift toward unified foundation models has revolutionized many deep learning domains, sleep medicine remains largely restricted to task-specific models that focus on localized micro-structure features. These approaches often…

Artificial Intelligence · Computer Science 2026-02-10 Keondo Park , Younghoon Na , Yourim Choi , Hyunwoo Ryu , Hyun-Woo Shin , Hyung-Sin Kim

Multimodal learning, especially large-scale multimodal pre-training, has developed rapidly over the past few years and led to the greatest advances in artificial intelligence (AI). Despite its effectiveness, understanding the underlying…

Neural and Evolutionary Computing · Computer Science 2022-08-18 Haoyu Lu , Qiongyi Zhou , Nanyi Fei , Zhiwu Lu , Mingyu Ding , Jingyuan Wen , Changde Du , Xin Zhao , Hao Sun , Huiguang He , Ji-Rong Wen

Neurological conditions, such as Alzheimer's Disease, are challenging to diagnose, particularly in the early stages where symptoms closely resemble healthy controls. Existing brain network analysis methods primarily focus on graph-based…

Neurons and Cognition · Quantitative Biology 2025-05-20 Jiaxing Xu , Kai He , Yue Tang , Wei Li , Mengcheng Lan , Xia Dong , Yiping Ke , Mengling Feng

Accurate brain tumor diagnosis relies on the assessment of multiple Magnetic Resonance Imaging (MRI) sequences. However, in clinical practice, the acquisition of certain sequences may be affected by factors like motion artifacts or contrast…

Image and Video Processing · Electrical Eng. & Systems 2025-05-30 Moinak Bhattacharya , Saumya Gupta , Annie Singh , Chao Chen , Gagandeep Singh , Prateek Prasanna

Objective: Endophenotypes such as brain age and fluid intelligence are important biomarkers of disease status. However, brain imaging studies to identify these biomarkers often encounter limited numbers of subjects and high dimensional…

Quantitative Methods · Quantitative Biology 2022-12-29 Anton Orlichenko , Gang Qu , Gemeng Zhang , Binish Patel , Tony W. Wilson , Julia M. Stephen , Vince D. Calhoun , Yu-Ping Wang

Feature selection is essential for high-dimensional biomedical data, enabling stronger predictive performance, reduced computational cost, and improved interpretability in precision medicine applications. Existing approaches face notable…

Machine Learning · Computer Science 2026-01-07 Xiaoyan Sun , Qingyu Meng , Yalu Wen

Accurate evaluation of the response of glioblastoma to therapy is crucial for clinical decision-making and patient management. The Response Assessment in Neuro-Oncology (RANO) criteria provide a standardized framework to assess patients'…

Computer Vision and Pattern Recognition · Computer Science 2025-09-09 Daniil Tikhonov , Matheus Scatolin , Mohor Banerjee , Qiankun Ji , Ahmed Jaheen , Mostafa Salem , Abdelrahman Elsayed , Hu Wang , Sarim Hashmi , Mohammad Yaqub

Foundation models show strong potential for large-scale, high-dimensional biomedical applications, yet their ability to capture relevant neurobiological characteristics remains underexplored. We systematically evaluate embeddings from two…

Signal Processing · Electrical Eng. & Systems 2026-04-17 Ye Tao , Bradley T. Baker , Yu Wu , Anand D. Sarwate , Sandeep Panta , Sergey Plis , Vince D. Calhoun

This study presents an unsupervised domain adaptation method aimed at autonomously generating image masks outlining regions of interest (ROIs) for differentiating breast lesions in breast ultrasound (US) imaging. Our semi-supervised…

Computer Vision and Pattern Recognition · Computer Science 2024-04-22 Ting-Ruen Wei , Michele Hell , Dang Bich Thuy Le , Aren Vierra , Ran Pang , Mahesh Patel , Young Kang , Yuling Yan

Functional Magnetic Resonance Imaging (fMRI) is an imaging technique widely used to study human brain activity. fMRI signals in areas across the brain transiently synchronise and desynchronise their activity in a highly structured manner,…

Machine Learning · Computer Science 2025-08-12 Yiran Huang , Amirhossein Nouranizadeh , Christine Ahrends , Mengjia Xu

An unprecedented amount of existing functional Magnetic Resonance Imaging (fMRI) data provides a new opportunity to understand the relationship between functional fluctuation and human cognition/behavior using a data-driven approach. To…

Machine Learning · Computer Science 2024-09-18 Jiaqi Ding , Tingting Dan , Ziquan Wei , Hyuna Cho , Paul J. Laurienti , Won Hwa Kim , Guorong Wu

Reliable and accurate registration of patient-specific brain magnetic resonance imaging (MRI) scans containing pathologies is challenging due to tissue appearance changes. This paper describes our contribution to the Registration of the…

Image and Video Processing · Electrical Eng. & Systems 2022-11-22 Ramy A. Zeineldin , Mohamed E. Karar , Franziska Mathis-Ullrich , Oliver Burgert

Large brain imaging databases contain a wealth of information on brain organization in the populations they target, and on individual variability. While such databases have been used to study group-level features of populations directly,…

Applications · Statistics 2019-06-19 Amanda F. Mejia , Mary Beth Nebel , Yikai Wang , Brian S. Caffo , Ying Guo

Brain activity is intrinsically a neural dynamic process constrained by anatomical space. This leads to significant variations in spatial distribution patterns and correlation patterns of neural activity across variable and heterogeneous…

Machine Learning · Computer Science 2026-03-10 Hongjie Jiang , Yifei Tang , Shuqiang Wang

Report-supervised (RSuper) learning seeks to alleviate the need for dense tumor voxel labels with constraints derived from radiology reports (e.g., volumes, counts, sizes, locations). In MRI studies of brain tumors, however, we often…

Image and Video Processing · Electrical Eng. & Systems 2026-02-25 Yubin Ge , Yongsong Huang , Xiaofeng Liu

Reliably modeling normality and differentiating abnormal appearances from normal cases is a very appealing approach for detecting pathologies in medical images. A plethora of such unsupervised anomaly detection approaches has been made in…

Computer Vision and Pattern Recognition · Computer Science 2019-04-19 Christoph Baur , Benedikt Wiestler , Shadi Albarqouni , Nassir Navab