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Brain foundation models have achieved remarkable advances across a wide range of neuroscience tasks. However, most existing models are limited to a single functional modality, restricting their ability to exploit complementary…

Machine Learning · Computer Science 2026-05-18 Hanning Guo , Hanwen Bi , Farah Abdellatif , Andrei Galbenus , Jon. N. Shah , Abigail Morrison , Jürgen Dammers

In medical imaging, most of the image registration methods implicitly assume a one-to-one correspondence between the source and target images (i.e., diffeomorphism). However, this is not necessarily the case when dealing with pathological…

Image and Video Processing · Electrical Eng. & Systems 2022-02-03 Matthis Maillard , Anton François , Joan Glaunès , Isabelle Bloch , Pietro Gori

In this study we adopt predictive modelling to identify simultaneously commonalities and differences in multi-modal brain networks acquired within subjects. Typically, predictive modelling of functional connectomes from structural…

Neurons and Cognition · Quantitative Biology 2019-11-06 Fani Deligianni , Jonathan D. Clayden , Guang-Zhong Yang

Functional connectivity (FC) studies have demonstrated the overarching value of studying the brain and its disorders through the undirected weighted graph of fMRI correlation matrix. Most of the work with the FC, however, depends on the way…

Neurons and Cognition · Quantitative Biology 2021-12-09 Usman Mahmood , Zening Fu , Vince Calhoun , Sergey Plis

The development of foundation models for functional magnetic resonance imaging (fMRI) time series holds significant promise for predicting phenotypes related to disease and cognition. Current models, however, are often trained using a…

Machine Learning · Computer Science 2026-03-03 Sam Gijsen , Marc-Andre Schulz , Kerstin Ritter

Understanding brain disorders is crucial for accurate clinical diagnosis and treatment. Recent advances in Multimodal Large Language Models (MLLMs) offer a promising approach to interpreting medical images with the support of text…

Image and Video Processing · Electrical Eng. & Systems 2025-06-03 Jing Zhang , Xiaowei Yu , Yanjun Lyu , Lu Zhang , Tong Chen , Chao Cao , Yan Zhuang , Minheng Chen , Tianming Liu , Dajiang Zhu

In latest years, deep learning has gained a leading role in the pansharpening of multiresolution images. Given the lack of ground truth data, most deep learning-based methods carry out supervised training in a reduced-resolution domain.…

Image and Video Processing · Electrical Eng. & Systems 2023-07-28 Matteo Ciotola , Giovanni Poggi , Giuseppe Scarpa

Self-supervised learning techniques are celebrating immense success in natural language processing (NLP) by enabling models to learn from broad language data at unprecedented scales. Here, we aim to leverage the success of these techniques…

Neurons and Cognition · Quantitative Biology 2023-01-18 Armin W. Thomas , Christopher Ré , Russell A. Poldrack

In recent years, there has been increasing attention on the capabilities of large models, particularly in handling complex tasks that small-scale models are unable to perform. Notably, large language models (LLMs) have demonstrated…

Artificial Intelligence · Computer Science 2025-08-07 Xiongye Xiao , Heng Ping , Chenyu Zhou , Defu Cao , Yaxing Li , Yi-Zhuo Zhou , Shixuan Li , Nikos Kanakaris , Paul Bogdan

Neuroscience and artificial intelligence represent distinct yet complementary pathways to general intelligence. However, amid the ongoing boom in AI research and applications, the translational synergy between these two fields has grown…

Neural and Evolutionary Computing · Computer Science 2026-01-30 Baiyu Chen , Yujie Wu , Siyuan Xu , Peng Qu , Dehua Wu , Xu Chu , Haodong Bian , Shuo Zhang , Bo Xu , Youhui Zhang , Zhengyu Ma , Guoqi Li

Foundation models, often pre-trained with large-scale data, have achieved paramount success in jump-starting various vision and language applications. Recent advances further enable adapting foundation models in downstream tasks efficiently…

Computer Vision and Pattern Recognition · Computer Science 2023-06-19 Dequan Wang , Xiaosong Wang , Lilong Wang , Mengzhang Li , Qian Da , Xiaoqiang Liu , Xiangyu Gao , Jun Shen , Junjun He , Tian Shen , Qi Duan , Jie Zhao , Kang Li , Yu Qiao , Shaoting Zhang

Masked autoencoders (MAEs) have recently shown promise for self-supervised representation learning of resting-state brain functional connectivity (FC). However, a fundamental question remains unresolved: how should FC matrices be tokenized…

Artificial Intelligence · Computer Science 2026-05-20 Leo Milecki , Qingyu Hu , Bahram Jafrasteh , Mert R. Sabuncu , Qingyu Zhao

Frontier artificial intelligence (AI) models, such as OpenAI's GPT-5 and Meta's DINOv3, have advanced rapidly through training on internet-scale public data, yet such systems lack access to private clinical data. Neuroimaging, in…

Combining multiple modalities carrying complementary information through multimodal learning (MML) has shown considerable benefits for diagnosing multiple pathologies. However, the robustness of multimodal models to missing modalities is…

Machine Learning · Computer Science 2024-07-31 Hava Chaptoukaev , Vincenzo Marcianó , Francesco Galati , Maria A. Zuluaga

As the deep learning revolution marches on, self-supervised learning has garnered increasing attention in recent years thanks to its remarkable representation learning ability and the low dependence on labeled data. Among these varied…

Computer Vision and Pattern Recognition · Computer Science 2024-01-10 Siyuan Li , Luyuan Zhang , Zedong Wang , Di Wu , Lirong Wu , Zicheng Liu , Jun Xia , Cheng Tan , Yang Liu , Baigui Sun , Stan Z. Li

Magnetic resonance imaging (MRI) has played a crucial role in fetal neurodevelopmental research. Structural annotations of MR images are an important step for quantitative analysis of the developing human brain, with Deep Learning providing…

Single-subject mapping of resting-state brain functional activity to non-imaging phenotypes is a major goal of neuroimaging. The large majority of learning approaches applied today rely either on static representations or on short-term…

Machine Learning · Computer Science 2022-08-09 Ahmed El-Gazzar , Rajat Mani Thomas , Guido Van Wingen

Background: Brain tumor segmentation has a significant impact on the diagnosis and treatment of brain tumors. Accurate brain tumor segmentation remains challenging due to their irregular shapes, vague boundaries, and high variability.…

Computer Vision and Pattern Recognition · Computer Science 2025-05-07 Zhanyuan Jia , Ni Yao , Danyang Sun , Chuang Han , Yanting Li , Jiaofen Nan , Fubao Zhu , Chen Zhao , Weihua Zhou

Harnessing the power of deep neural networks in the medical imaging domain is challenging due to the difficulties in acquiring large annotated datasets, especially for rare diseases, which involve high costs, time, and effort for…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Md Mahfuzur Rahman Siddiquee , Jay Shah , Teresa Wu , Catherine Chong , Todd J. Schwedt , Gina Dumkrieger , Simona Nikolova , Baoxin Li

Brain networks characterize complex connectivities among brain regions as graph structures, which provide a powerful means to study brain connectomes. In recent years, graph neural networks have emerged as a prevalent paradigm of learning…

Machine Learning · Computer Science 2022-06-10 Yi Yang , Yanqiao Zhu , Hejie Cui , Xuan Kan , Lifang He , Ying Guo , Carl Yang
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