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Living cells dynamically modulate the local morphologies of their actin cytoskeletons to perform biological functions, including force transduction, intracellular transport, and cell division. A major challenge is to understand how diverse…

Biological Physics · Physics 2018-12-07 Simon L. Freedman , Glen M. Hocky , Shiladitya Banerjee , Aaron R. Dinner

In the context of self-assembly, where complex structures can be assembled from smaller units, it is desirable to devise strategies towards disassembly and reassembly processes that reuse the constituent parts. A non-reciprocal multifarious…

Soft Condensed Matter · Physics 2025-09-30 Jakob Metson , Saeed Osat , Ramin Golestanian

The goal of inverse self-assembly is to design inter-particle interactions capable of assembling the units into a desired target structure. The effective assembly of complex structures often requires the use of multiple components, each new…

Soft Condensed Matter · Physics 2023-11-08 Camilla Beneduce , Francesco Sciortino , Petr Sulc , John Russo

Physical learning is an emerging paradigm in science and engineering whereby (meta)materials acquire desired macroscopic behaviors by exposure to examples. So far, it has been applied to static properties such as elastic moduli and…

The functioning of machines typically requires a concerted action of their parts. This requirement also holds for molecular motors that drive vital cellular processes and imposes constraints on their conformational changes as well as the…

Biological Physics · Physics 2022-06-14 Zena Hadjivasiliou , Karsten Kruse

Self-organized complex structures in nature, e.g. viral capsids, hierarchical biopolymers, and bacterial flagella, offer efficiency, adaptability, robustness, and multi-functionality. Can we program the self-assembly of three-dimensional…

Soft Condensed Matter · Physics 2022-01-11 Francesco Serafin , Jun Lu , Nicholas Kotov , Kai Sun , Xiaoming Mao

Multifarious assembly models consider multiple structures assembled from a shared set of components, reflecting the efficient usage of components in biological self-assembly. These models are subject to a high-dimensional parameter space,…

Soft Condensed Matter · Physics 2025-09-30 Jakob Metson , Saeed Osat , Ramin Golestanian

Self-organization is the autonomous assembly of a network of interacting components into a stable, organized pattern. This article shows that the process of self-assembly can be encoded in terms of evolutionary entropy, a statistical…

Statistical Mechanics · Physics 2023-05-29 Lloyd A. Demetrius

Self-assembly plays an essential role in many natural processes, involving the formation and evolution of living or non-living structures, and shows potential applications in many emerging domains. In existing research and practice, there…

Multiagent Systems · Computer Science 2021-02-24 Wenjie Chu , Wei Zhang , Haiyan Zhao , Zhi Jin , Hong Mei

We consider an important class of self-assembly problems and using the formalism of stochastic thermodynamics, we derive a set of design principles for growing controlled assemblies far from equilibrium. The design principles constrain the…

Statistical Mechanics · Physics 2017-01-17 Michael Nguyen , Suriyanarayanan Vaikuntanathan

We introduce structural heterogeneity, a new topological characteristic for semi-ordered materials that captures their degree of organisation at a mesoscopic level and tracks their time-evolution, ultimately detecting the order-disorder…

Modern experimental methods enable the creation of self-assembly building blocks with tunable interactions, but optimally exploiting this tunability for the self-assembly of desired structures remains an important challenge. Many studies of…

Soft Condensed Matter · Physics 2025-07-10 Maximilian C. Hübl , Carl P. Goodrich

We present fast simulation methods for the self-assembly of complex shapes in two dimensions. The shapes are modeled via a general boundary curve and interact via a standard volume term promoting overlap and an interpenetration penalty. To…

Computational Physics · Physics 2023-12-11 Lukas Mayrhofer , Myfanwy E. Evans , Gero Friesecke

Bacterial microcompartments are large, roughly icosahedral shells that assemble around enzymes and reactants involved in certain metabolic pathways in bacteria. Motivated by microcompartment assembly, we use coarse-grained computational and…

Biological Physics · Physics 2019-05-07 Farzaneh Mohajerani , Michael F. Hagan

We simulate crystallisation of hard spheres with short-ranged attractive potentials, as a model self-assembling system. We show how measurements of correlation and response functions during assembly can be used to tune the interaction…

Soft Condensed Matter · Physics 2014-03-10 Daphne Klotsa , Robert L. Jack

We present a generic framework for modelling three-dimensional deformable shells of active matter that captures the orientational dynamics of the active particles and hydrodynamic interactions on the shell and with the surrounding…

Soft Condensed Matter · Physics 2019-11-20 Luuk Metselaar , Julia M. Yeomans , Amin Doostmohammadi

Manipulating the way in which colloidal particles self-organise is a central challenge in the design of functional soft materials. Meeting this challenge requires the use of building blocks that interact with one another in a highly…

Soft Condensed Matter · Physics 2021-03-30 Joe G Donaldson , Peter Schall , Laura Rossi

Structural quantities such as order parameters and correlation functions are often employed to gain insight into the physical behavior and properties of condensed matter systems. While standard quantities for characterizing structure exist,…

Soft Condensed Matter · Physics 2017-08-23 Aaron S. Keys , Christopher R. Iacovella , Sharon C. Glotzer

We present an analytically solvable model for self-assembly of a molecular complex on a filament. The process is driven by a seed molecule that undergoes facilitated diffusion, which is a search strategy that combines diffusion in…

Statistical Mechanics · Physics 2015-11-04 Ziya Kalay

A self-organization is an universal phenomenon in nature and, in particular, is highly important in materials systems and biology. We proposed a new theory that allowed us to model the most challenging cases of atomic self-assembling whose…

Other Condensed Matter · Physics 2014-11-25 M. Lavrskyi , H. Zapolsky , A. G. Khachaturyan
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