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Cerebral blood flow and perfusion can be estimated using tracer dilution experiments. Accurate estimation of blood flow parameters is a crucial part of medical imaging for effective diagnosis and treatment. This study explores two themes:…
This paper addresses the problem of high-resolution Doppler blood flow estimation from an ultrafast sequence of ultrasound images. Formulating the separation of clutter and blood components as an inverse problem has been shown in the…
CT Perfusion (CTP) imaging has gained importance in the diagnosis of acute stroke. Conventional perfusion analysis performs a deconvolution of the measurements and thresholds the perfusion parameters to determine the tissue status. We…
Perfusion analysis computes blood flow parameters (blood volume, blood flow, mean transit time) from the observed flow of contrast agent, passing through the patient's vascular system. Perfusion deconvolution has been widely accepted as the…
The impulse response function (IRF) of a localized bolus in cerebral blood flow codes important information on the tissue type. It is indirectly accessible both from MR- and CT-imaging methods, at least in principle. In practice, however,…
Accurate detection of arterial input function is a crucial step in obtaining perfusion hemodynamic parameters using dynamic susceptibility contrast-enhanced magnetic resonance imaging. It is required as input for perfusion quantification…
Perfusion imaging plays a crucial role in acute stroke diagnosis and treatment decision making. Current perfusion analysis relies on deconvolution of the measured signals, an operation that is mathematically ill-conditioned and requires…
Ultrasound is widely used in medical diagnostics allowing for accessible and powerful imaging but suffers from resolution limitations due to diffraction and the finite aperture of the imaging system, which restricts diagnostic use. The…
Perfusion imaging is crucial in acute ischemic stroke for quantifying the salvageable penumbra and irreversibly damaged core lesions. As such, it helps clinicians to decide on the optimal reperfusion treatment. In perfusion CT imaging,…
The interest of compressive sampling in ultrasound imaging has been recently extensively evaluated by several research teams. Following the different application setups, it has been shown that the RF data may be reconstructed from a small…
Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) is widely used to evaluate acute ischemic stroke to distinguish salvageable tissue and infarct core. For this purpose, traditional methods employ deconvolution techniques,…
The reconstruction of physically valid transport fields from subject-specific imaging data is a fundamental challenge in image-based computational modeling due to measurement noise, modeling uncertainties and discretization errors. Without…
High resolution ultrasound image reconstruction from a reduced number of measurements is of great interest in ultrasound imaging, since it could enhance both the frame rate and image resolution. Compressive deconvolution, combining…
This paper introduces a computationally efficient technique for estimating high-resolution Doppler blood flow from an ultrafast ultrasound image sequence. More precisely, it consists in a new fast alternating minimization algorithm that…
Computer vision methods typically optimize for first-order dynamics (e.g., optical flow). However, in many cases the properties of interest are subtle variations in higher-order changes, such as acceleration. This is true in the cardiac…
This paper worked towards modeling blood platelets. Blood platelets, also known as thrombocytes, play a key role in blood clotting which is a vital human function. Furthermore, the role of these entities in strokes, myocardial infarctions,…
In this article we recover the distribution function (and possible density) of an arbitrary random variable that is subject to an additive measurement error. This problem is also known as deconvolution and has a long tradition in…
Convolution system is linear and time invariant, and can describe the optical imaging process. Based on convolution system, many deconvolution techniques have been developed for optical image analysis, such as boosting the space resolution…
Functional ultrasound (fUS) indirectly measures brain activity by recording changes in cerebral blood volume and flow in response to neural activation. Conventional approaches model such functional neuroimaging data as the convolution…
The aim of this paper is to discuss potential advances in PET kinetic models and direct reconstruction of kinetic parameters. As a prominent example we focus on a typical task in perfusion imaging and derive a system of…