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Energy system optimization models (ESOMs) should be used in an interactive way to uncover knife-edge solutions, explore alternative system configurations, and suggest different ways to achieve policy objectives under conditions of deep…

Physics and Society · Physics 2019-12-10 Joseph F. DeCarolis , Samaneh Babaee , Binghui Li , Suyash Kanungo

Concrete is the most widely used engineered material in the world with more than 10 billion tons produced annually. Unfortunately, with that scale comes a significant burden in terms of energy, water, and release of greenhouse gases and…

Artificial Intelligence · Computer Science 2019-05-21 Xiou Ge , Richard T. Goodwin , Jeremy R. Gregory , Randolph E. Kirchain , Joana Maria , Lav R. Varshney

Optimizing chemical properties is a challenging task due to the vastness and complexity of chemical space. Here, we present a generative energy-based architecture for implicit chemical property optimization, designed to efficiently generate…

Biomolecules · Quantitative Biology 2025-06-19 Luca Miglior , Lorenzo Simone , Marco Podda , Davide Bacciu

We present a non-convex optimization algorithm metaheuristic, based on the training of a deep generative network, which enables effective searching within continuous, ultra-high dimensional landscapes. During network training, populations…

Machine Learning · Computer Science 2023-07-11 Jiaqi Jiang , Jonathan A. Fan

Based on a recently introduced metric for measuring distances between configurations, we in- troduce distance-energy (DE) plots to characterize the potential energy surface (PES) of clusters. Producing such plots is computationally feasible…

Atomic and Molecular Clusters · Physics 2013-11-19 Sandip De , Bastian Schaefer , Ali Sadeghi , Michael Sicher , D. G. Kanhere , Stefan Goedecker

Despite the increasing interest in constrained multiobjective optimization in recent years, constrained multiobjective optimization problems (CMOPs) are still unsatisfactory understood and characterized. For this reason, the selection of…

Neural and Evolutionary Computing · Computer Science 2022-06-15 Aljoša Vodopija , Tea Tušar , Bogdan Filipič

In real-life applications, most optimization problems are variants of well-known combinatorial optimization problems, including additional constraints to fit with a particular use case. Usually, efficient algorithms to handle a restricted…

Discrete Mathematics · Computer Science 2025-01-24 Sébastien Martin , Pierre Bauguion , Youcef Magnouche , Jérémie Leguay

Optimization algorithms are widely employed to tackle complex problems, but designing them manually is often labor-intensive and requires significant expertise. Global placement is a fundamental step in electronic design automation (EDA).…

Neural and Evolutionary Computing · Computer Science 2025-04-28 Xufeng Yao , Jiaxi Jiang , Yuxuan Zhao , Peiyu Liao , Yibo Lin , Bei Yu

Exploring molecular energy landscapes and identifying ground-state conformations are central challenges in computational chemistry. However, generating diverse low-energy conformers from molecular graphs remains expensive with traditional…

Machine Learning · Computer Science 2026-05-25 Guikun Xu , Xiaohan Yi , Ziqiao Meng , Peilin Zhao , Yatao Bian

Viewing neural network models in terms of their loss landscapes has a long history in the statistical mechanics approach to learning, and in recent years it has received attention within machine learning proper. Among other things, local…

Machine Learning · Computer Science 2021-12-14 Yaoqing Yang , Liam Hodgkinson , Ryan Theisen , Joe Zou , Joseph E. Gonzalez , Kannan Ramchandran , Michael W. Mahoney

We show how the localization landscape, originally introduced to bound low energy eigenstates of disordered wave media and many-body quantum systems, can form the basis for hardware-efficient quantum algorithms for solving binary…

Quantum Physics · Physics 2023-07-06 Benjamin Y. L. Tan , Beng Yee Gan , Daniel Leykam , Dimitris G. Angelakis

Discrete choice experiments (DCEs) investigate the attributes that influence individuals' choices when selecting among various options. To enhance the quality of the estimated choice models, researchers opt for Bayesian optimal designs that…

Methodology · Statistics 2025-04-01 Yicheng Mao , Roselinde Kessels , Tom van der Zanden

Identifying a suitable set of descriptors for modeling physical systems often utilizes either deep physical insights or statistical methods such as compressed sensing. In statistical learning, a class of methods known as structured sparsity…

Materials Science · Physics 2019-10-30 Zhidong Leong , Teck Leong Tan

The potential energy surface (PES) is crucial for interpreting a variety of chemical reaction processes. However, predicting accurate PESs with high-level electronic structure methods is a challenging task due to the high computational…

Chemical Physics · Physics 2022-06-09 Yanxian Tao , Xiongzhi Zeng , Yi Fan , Jie Liu , Zhenyu Li , Jinlong Yang

We introduce a method for global optimization of the structure of atomic systems that uses additional atoms with fractional existence. The method allows for movement of atoms over long distances bypassing energy barriers encountered in the…

The identification of low-energy conformers for a given molecule is a fundamental problem in computational chemistry and cheminformatics. We assess here a conformer search that employs a genetic algorithm for sampling the low-energy segment…

Biomolecules · Quantitative Biology 2015-11-24 Adriana Supady , Volker Blum , Carsten Baldauf

We present a study of the potential energy surface (PES) of anthracene, tetracene and pentacene clusters with up to 30 molecules. We have applied the basin-hopping Monte Carlo (BHMC) algorithm to clusters of acene molecules in order to find…

Atomic and Molecular Clusters · Physics 2023-03-07 Philipp Elsässer , Tanja Schilling

We perform a comprehensive survey of the potential energy landscapes of 13-atom Morse clusters, and describe how they can be characterized and visualized. Our aim is to detail how the global features of the funnel-like surface change with…

Statistical Mechanics · Physics 2009-10-31 Mark A. Miller , Jonathan P. K. Doye , David J. Wales

We describe a local surrogate model for use in conjunction with global structure search methods. The model follows the Gaussian approximation potential (GAP) formalism and is based on a the smooth overlap of atomic positions descriptor with…

Many real-world problems require making sequences of decisions where the outcomes of each decision are probabilistic and uncertain, and the availability of different actions is constrained by the outcomes of previous actions. There is a…

Optimization and Control · Mathematics 2025-04-28 Berk Ozturk , She'ifa Punla-Green , Les Servi