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Protein phosphorylation cycles are important mechanisms of the post translational modification of a protein and as such an integral part of intracellular signaling and control. We consider the sequential phosphorylation and…
Phosphorylation networks, representing the mechanisms by which proteins are phosphorylated at one or multiple sites, are ubiquitous in cell signalling and display rich dynamics such as unlimited multistability. Dual-site phosphorylation…
This work investigates the emergence of oscillations in one of the simplest cellular signaling networks exhibiting oscillations, namely, the dual-site phosphorylation and dephosphorylation network (futile cycle), in which the mechanism for…
Autonomous sustained oscillations are ubiquitous in living and nonliving systems. As open systems, far from thermodynamic equilibrium, they defy entropic laws which mandate convergence to stationarity. We present structural conditions on…
For many physical systems the transition from a stationary solution to sustained small amplitude oscillations corresponds to a Hopf bifurcation. For systems involving impacts, thresholds, switches, or other abrupt events, however, this…
Deciding whether and where a system of parametrized ordinary differential equations displays bistability, that is, has at least two asymptotically stable steady states for some choice of parameters, is a hard problem. For systems modeling…
We investigate the steady-state solution and its bifurcations in time-delay systems with band-limited feedback. This is a first step in a rigorous study concerning the effects of AC-coupled components in nonlinear devices with time-delayed…
Real power systems exhibit dynamics that evolve across a wide range of time scales, from very fast to very slow phenomena. Historically, incorporating these wide-ranging dynamics into a single model has been impractical. As a result, power…
A general FitzHugh-Rinzel model, able to describe several neuronal phenomena, is considered. Linear stability and Hopf bifurcations are investigated by means of the spectral equation for the ternary autonomous dynamical system and the…
Based on the generalized Routh-Hurwitz criterion, we propose a sufficient and necessary criterion for testing the stability of fractional-order linear systems with order {\alpha}{\in}[1,2), called the fractional-order Routh-Hurwitz…
Quantifying the stability of an equilibrium is central in the theory of dynamical systems as well as in engineering and control. A comprehensive picture must include the response to both small and large perturbations, leading to the…
A Hopf bifurcation criterion of fractional-order systems with order 1 < {\alpha} < 2 is established in this paper, in which all conditions are explicitly expressed by parameters without solving the roots of the relevant characteristic…
In the design of decentralized networked systems, it is useful to know whether a given network topology can sustain stable dynamics. We consider a basic version of this problem here: given a vector space of sparse real matrices, does it…
This paper aims at extending the criterion that the quasi-stability of a polynomial is equivalent to the total nonnegativity of its Hurwitz matrix. We give a complete description of functions generating doubly infinite series with totally…
Ordered distributive double phosphorylation is a recurrent motif in intracellular signaling and control. It is either sequential (where the site phosphorylated last is dephosphorylated first) or cyclic (where the site phosphorylated first…
In this work, we conduct a rigorous analysis on the dynamics of a predator-prey model with cooperative predation. From the root classification of an algebraic equation, we derive existence criteria of the positive equilibria. By Jacobian…
We review some properties of dynamical systems with slowly varying parameters, when a parameter is moved through a bifurcation point of the static system. Bifurcations with a single zero eigenvalue may create hysteresis cycles, whose area…
A four-dimensional mathematical model of the hypothalamus-pituitary-adrenal (HPA) axis is investigated, incorporating the influence of the GR concentration and general feedback functions. The inclusion of distributed time delays provides a…
On a two-dimensional circular domain, we analyze the formation of spatio-temporal patterns for a class of coupled bulk-surface reaction-diffusion models for which a passive diffusion process occurring in the interior bulk domain is linearly…
We consider a broad class of second-order dynamical systems and study the impact of damping as a system parameter on the stability, hyperbolicity, and bifurcation in such systems. We prove a monotonic effect of damping on the hyperbolicity…