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The safe deployment of large language models (LLMs) in high-stakes fields like biomedicine, requires them to be able to reason about cause and effect. We investigate this ability by testing 13 open-source LLMs on a fundamental task:…

Computation and Language · Computer Science 2026-03-13 Sydney Anuyah , Sneha Shajee-Mohan , Ankit-Singh Chauhan , Sunandan Chakraborty

As the significance of understanding the cause-and-effect relationships among variables increases in the development of modern systems and algorithms, learning causality from observational data has become a preferred and efficient approach…

Machine Learning · Computer Science 2024-11-28 Xiaoxuan Li , Yao Liu , Ruoyu Wang , Lina Yao

Causal graph recovery is traditionally done using statistical estimation-based methods or based on individual's knowledge about variables of interests. They often suffer from data collection biases and limitations of individuals' knowledge.…

Computation and Language · Computer Science 2024-06-19 Yuzhe Zhang , Yipeng Zhang , Yidong Gan , Lina Yao , Chen Wang

To perform effective causal inference in high-dimensional datasets, initiating the process with causal discovery is imperative, wherein a causal graph is generated based on observational data. However, obtaining a complete and accurate…

Machine Learning · Computer Science 2025-04-18 Elahe Khatibi , Mahyar Abbasian , Zhongqi Yang , Iman Azimi , Amir M. Rahmani

With the advent of larger and more complex deep learning models, such as in Natural Language Processing (NLP), model qualities like explainability and interpretability, albeit highly desirable, are becoming harder challenges to tackle and…

Computation and Language · Computer Science 2024-01-30 Amrita Bhattacharjee , Raha Moraffah , Joshua Garland , Huan Liu

Understanding causality is key to the success of NLP applications, especially in high-stakes domains. Causality comes in various perspectives such as enable and prevent that, despite their importance, have been largely ignored in the…

Computation and Language · Computer Science 2022-04-18 Linyi Yang , Zhen Wang , Yuxiang Wu , Jie Yang , Yue Zhang

In knowledge-intensive tasks, especially in high-stakes domains like medicine and law, it is critical not only to retrieve relevant information but also to provide causal reasoning and explainability. Large language models (LLMs) have…

Artificial Intelligence · Computer Science 2025-03-18 Hang Luo , Jian Zhang , Chujun Li

Estimating individualized treatment effects from observational data presents a persistent challenge due to unmeasured confounding and structural bias. Causal Machine Learning (causal ML) methods, such as causal trees and doubly robust…

Machine Learning · Computer Science 2025-08-12 Po-Han Lee , Yu-Cheng Lin , Chan-Tung Ku , Chan Hsu , Pei-Cing Huang , Ping-Hsun Wu , Yihuang Kang

Causal inference remains a fundamental challenge for large language models. Recent advances in internal reasoning with large language models have sparked interest in whether state-of-the-art reasoning models can robustly perform causal…

Artificial Intelligence · Computer Science 2025-08-01 Kacper Kadziolka , Saber Salehkaleybar

Causal reasoning is a cornerstone of how humans interpret the world. To model and reason about causality, causal graphs offer a concise yet effective solution. Given the impressive advancements in language models, a crucial question arises:…

Computation and Language · Computer Science 2024-06-25 Sirui Chen , Mengying Xu , Kun Wang , Xingyu Zeng , Rui Zhao , Shengjie Zhao , Chaochao Lu

Large Language Models (LLMs) have shown their success in language understanding and reasoning on general topics. However, their capability to perform inference based on user-specified structured data and knowledge in corpus-rare concepts,…

Computation and Language · Computer Science 2024-10-29 Haitao Jiang , Lin Ge , Yuhe Gao , Jianian Wang , Rui Song

Counterfactual reasoning has emerged as a crucial technique for generalizing the reasoning capabilities of large language models (LLMs). By generating and analyzing counterfactual scenarios, researchers can assess the adaptability and…

Artificial Intelligence · Computer Science 2026-02-17 Shuai Yang , Qi Yang , Luoxi Tang , Yuqiao Meng , Nancy Guo , Jeremy Blackburn , Zhaohan Xi

Recent claims of strong performance by Large Language Models (LLMs) on causal discovery are undermined by a key flaw: many evaluations rely on benchmarks likely included in pretraining corpora. Thus, apparent success suggests that LLM-only…

Recent breakthroughs in artificial intelligence have driven a paradigm shift, where large language models (LLMs) with billions or trillions of parameters are trained on vast datasets, achieving unprecedented success across a series of…

Computation and Language · Computer Science 2024-10-22 Anpeng Wu , Kun Kuang , Minqin Zhu , Yingrong Wang , Yujia Zheng , Kairong Han , Baohong Li , Guangyi Chen , Fei Wu , Kun Zhang

Large Language Models (LLMs) show promise in biomedicine but lack true causal understanding, relying instead on correlations. This paper envisions causal LLM agents that integrate multimodal data (text, images, genomics, etc.) and perform…

Artificial Intelligence · Computer Science 2025-05-23 Adib Bazgir , Amir Habibdoust Lafmajani , Yuwen Zhang

Genes, proteins and other biological entities influence one another via causal molecular networks. Causal relationships in such networks are mediated by complex and diverse mechanisms, through latent variables, and are often specific to…

Machine Learning · Computer Science 2025-03-07 Izzy Newsham , Luka Kovačević , Richard Moulange , Nan Rosemary Ke , Sach Mukherjee

In causal inference, generalization capability refers to the ability to conduct causal inference methods on new data to estimate the causal-effect between unknown phenomenon, which is crucial for expanding the boundaries of knowledge.…

Computation and Language · Computer Science 2024-10-16 Chen Wang , Dongming Zhao , Bo Wang , Ruifang He , Yuexian Hou

As language models (LMs) deliver increasing performance on a range of NLP tasks, probing classifiers have become an indispensable technique in the effort to better understand their inner workings. A typical setup involves (1) defining an…

Computation and Language · Computer Science 2024-08-01 Charles Jin , Martin Rinard

Despite their strong performance on reasoning benchmarks, large language models (LLMs) have proven brittle when presented with counterfactual questions, suggesting weaknesses in their causal reasoning ability. While recent work has…

Machine Learning · Computer Science 2026-02-20 Victoria Lin , Xinnuo Xu , Rachel Lawrence , Risa Ueno , Amit Sharma , Javier Gonzalez , Niranjani Prasad

Causal discovery for both cross-sectional and temporal data has traditionally followed a dataset-specific paradigm, where a new model is fitted for each individual dataset. Such an approach limits the potential of multi-dataset pretraining.…