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Machine Learning (ML) models are widely used in high-stakes domains such as healthcare, where the reliability of predictions is critical. However, these models often fail to account for uncertainty, providing predictions even with low…

As machine learning (ML) systems increasingly permeate high-stakes settings such as healthcare, transportation, military, and national security, concerns regarding their reliability have emerged. Despite notable progress, the performance of…

Machine Learning · Computer Science 2023-08-01 Anthony Corso , David Karamadian , Romeo Valentin , Mary Cooper , Mykel J. Kochenderfer

Reliably predicting potential failure risks of machine learning (ML) systems when deployed with production data is a crucial aspect of trustworthy AI. This paper introduces Risk Advisor, a novel post-hoc meta-learner for estimating failure…

Machine Learning · Computer Science 2021-09-10 Preethi Lahoti , Krishna P. Gummadi , Gerhard Weikum

Machine learning (ML) models show strong promise for new biomedical prediction tasks, but concerns about trustworthiness have hindered their clinical adoption. In particular, it is often unclear whether a model relies on true clinical cues…

Machine Learning · Computer Science 2026-01-13 Dushan N. Wadduwage , Dineth Jayakody , Leonidas Zimianitis

Machine learning models have become integral to many fields, but their reliability, defined as producing dependable, trustworthy, and domain-consistent predictions, remains a critical concern. Multiple Instance Learning (MIL) models…

Computer Vision and Pattern Recognition · Computer Science 2025-12-10 Hassan Keshvarikhojasteh , Marc Aubreville , Christof A. Bertram , Josien P. W. Pluim , Mitko Veta

Machine learning (ML) systems are increasingly deployed in high-stakes domains where reliability is paramount. This thesis investigates how uncertainty estimation can enhance the safety and trustworthiness of ML, focusing on selective…

Machine Learning · Computer Science 2025-09-09 Stephan Rabanser

Decisions by Machine Learning (ML) models have become ubiquitous. Trusting these decisions requires understanding how algorithms take them. Hence interpretability methods for ML are an active focus of research. A central problem in this…

Machine Learning · Computer Science 2019-01-25 Philipp Schmidt , Felix Biessmann

As artificial intelligence systems move toward clinical deployment, ensuring reliable prediction behavior is fundamental for safety-critical decision-making tasks. One proposed safeguard is selective prediction, where models can defer…

Machine Learning · Computer Science 2026-05-25 L. Julián Lechuga López , Farah E. Shamout , Tim G. J. Rudner

To develop rigorous knowledge about ML models -- and the systems in which they are embedded -- we need reliable measurements. But reliable measurement is fundamentally challenging, and touches on issues of reproducibility, scalability,…

Machine Learning · Computer Science 2024-08-13 A. Feder Cooper

Artificial intelligence (AI), and especially its sub-field of Machine Learning (ML), are impacting the daily lives of everyone with their ubiquitous applications. In recent years, AI researchers and practitioners have introduced principles…

Machine Learning · Computer Science 2024-10-30 Firas Bayram , Bestoun S. Ahmed

Machine learning models built on datasets containing discriminative instances attributed to various underlying factors result in biased and unfair outcomes. It's a well founded and intuitive fact that existing bias mitigation strategies…

Machine Learning · Computer Science 2022-10-25 Bhushan Chaudhari , Akash Agarwal , Tanmoy Bhowmik

Reliability is a fundamental challenge in operating large-scale machine learning (ML) infrastructures, particularly as the scale of ML models and training clusters continues to grow. Despite decades of research on infrastructure failures,…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-02-10 Apostolos Kokolis , Michael Kuchnik , John Hoffman , Adithya Kumar , Parth Malani , Faye Ma , Zachary DeVito , Shubho Sengupta , Kalyan Saladi , Carole-Jean Wu

Material scientists are increasingly adopting the use of machine learning (ML) for making potentially important decisions, such as, discovery, development, optimization, synthesis and characterization of materials. However, despite ML's…

Computational Physics · Physics 2019-03-12 Bhavya Kailkhura , Brian Gallagher , Sookyung Kim , Anna Hiszpanski , T. Yong-Jin Han

Machine Learning (ML) models are often complex and difficult to interpret due to their 'black-box' characteristics. Interpretability of a ML model is usually defined as the degree to which a human can understand the cause of decisions…

Methodology · Statistics 2020-06-25 Simon Kocbek , Primoz Kocbek , Leona Cilar , Gregor Stiglic

Machine learning models only provide probabilistic guarantees on the expected loss of random samples from the distribution represented by their training data. As a result, a model with high accuracy, may or may not be reliable for…

Databases · Computer Science 2024-04-12 Nima Shahbazi , Abolfazl Asudeh

Advanced classification algorithms are being increasingly used in safety-critical applications like health-care, engineering, etc. In such applications, miss-classifications made by ML algorithms can result in substantial financial or…

Machine Learning · Computer Science 2024-12-06 Disha Ghandwani , Neeraj Sarna , Yuanyuan Li , Yang Lin

The use of machine learning systems in clinical routine is still hampered by the necessity of a medical device certification and/or by difficulty to implement these systems in a clinic's quality management system. In this context, the key…

Medical Physics · Physics 2022-10-18 Lorenzo Mercolli , Axel Rominger , Kuangyu Shi

Trustworthy artificial intelligence (AI) is essential in healthcare, particularly for high-stakes tasks like medical image segmentation. Explainable AI and uncertainty quantification significantly enhance AI reliability by addressing key…

Machine learning (ML) models are increasingly being used in application domains that often involve working together with human experts. In this context, it can be advantageous to defer certain instances to a single human expert when they…

Artificial Intelligence · Computer Science 2022-06-17 Patrick Hemmer , Sebastian Schellhammer , Michael Vössing , Johannes Jakubik , Gerhard Satzger

Estimating how often an ML model will fail at deployment scale is central to pre-deployment safety assessment, but a feasible evaluation set is rarely large enough to observe the failures that matter. Jones et al. (2025) address this by…

Machine Learning · Computer Science 2026-05-18 Will Schwarzer , Scott Niekum
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