English
Related papers

Related papers: Molecule Design by Latent Prompt Transformer

200 papers

Generative models, especially diffusion models (DMs), have achieved promising results for generating feature-rich geometries and advancing foundational science problems such as molecule design. Inspired by the recent huge success of Stable…

Machine Learning · Computer Science 2023-05-03 Minkai Xu , Alexander Powers , Ron Dror , Stefano Ermon , Jure Leskovec

Recently a variety of LSTM-based conditional language models (LM) have been applied across a range of language generation tasks. In this work we study various model architectures and different ways to represent and aggregate the source…

Computation and Language · Computer Science 2016-06-13 Tsung-Hsien Wen , Milica Gasic , Nikola Mrksic , Lina M. Rojas-Barahona , Pei-Hao Su , Stefan Ultes , David Vandyke , Steve Young

Deep generative neural networks have proven effective at both conditional and unconditional modeling of complex data distributions. Conditional generation enables interactive control, but creating new controls often requires expensive…

Machine Learning · Computer Science 2017-12-25 Jesse Engel , Matthew Hoffman , Adam Roberts

Generative molecular optimization aims to design molecules with properties surpassing those of existing compounds. However, such candidates are rare and expensive to evaluate, yielding sample efficiency essential. Additionally, surrogate…

While various models and computational tools have been proposed for structure and property analysis of molecules, generating molecules that conform to all desired structures and properties remains a challenge. Here, we introduce a…

Computation and Language · Computer Science 2024-10-11 Peng Zhou , Jianmin Wang , Chunyan Li , Zixu Wang , Yiping Liu , Siqi Sun , Jianxin Lin , Leyi Wei , Xibao Cai , Houtim Lai , Wei Liu , Longyue Wang , Yuansheng Liu , Xiangxiang Zeng

Molecule generation requires satisfying multiple chemical and biological constraints while searching a large and structured chemical space. This makes it a non-binary problem, where effective models must identify non-obvious solutions under…

Computation and Language · Computer Science 2026-04-21 Wen Tao , Yiwei Wang , Peng Zhou , Bryan Hooi , Wanlong Fang , Tianle Zhang , Xiao Luo , Yuansheng Liu , Alvin Chan

Large language models (LLMs) like ChatGPT and GPT-4 have attracted great attention given their surprising performance on a wide range of NLP tasks. Length controlled generation of LLMs emerges as an important topic, which enables users to…

Computation and Language · Computer Science 2023-10-03 Renlong Jie , Xiaojun Meng , Lifeng Shang , Xin Jiang , Qun Liu

Generative LLMs, such as GPT, have the potential to revolutionize Requirements Engineering (RE) by automating tasks in new ways. This column explores the novelties and introduces the importance of precise prompts for effective interactions.…

Software Engineering · Computer Science 2024-08-20 Andreas Vogelsang

Large Language Models (LLMs) are revolutionizing the field of computing education with their powerful code-generating capabilities. Traditional pedagogical practices have focused on code writing tasks, but there is now a shift in importance…

Human-Computer Interaction · Computer Science 2023-11-13 Paul Denny , Juho Leinonen , James Prather , Andrew Luxton-Reilly , Thezyrie Amarouche , Brett A. Becker , Brent N. Reeves

Prompt learning has become a prevalent strategy for adapting vision-language foundation models to downstream tasks. As large language models (LLMs) have emerged, recent studies have explored the use of category-related descriptions as input…

Computer Vision and Pattern Recognition · Computer Science 2023-12-12 Yubin Wang , Xinyang Jiang , De Cheng , Dongsheng Li , Cairong Zhao

Designing proteins with specific attributes offers an important solution to address biomedical challenges. Pre-trained protein large language models (LLMs) have shown promising results on protein sequence generation. However, to control…

Artificial Intelligence · Computer Science 2025-01-28 Xiangyu Liu , Yi Liu , Silei Chen , Wei Hu

Prompt engineering has emerged as an indispensable technique for extending the capabilities of large language models (LLMs) and vision-language models (VLMs). This approach leverages task-specific instructions, known as prompts, to enhance…

Artificial Intelligence · Computer Science 2025-03-18 Pranab Sahoo , Ayush Kumar Singh , Sriparna Saha , Vinija Jain , Samrat Mondal , Aman Chadha

With the recent advances in machine learning for quantum chemistry, it is now possible to predict the chemical properties of compounds and to generate novel molecules. Existing generative models mostly use a string- or graph-based…

Biomolecules · Quantitative Biology 2020-10-14 Vitali Nesterov , Mario Wieser , Volker Roth

Retrieval-augmented language models (LMs) have received much attention recently. However, typically the retriever is not trained jointly as a native component of the LM, but added post-hoc to an already-pretrained LM, which limits the…

Computation and Language · Computer Science 2024-07-23 Ohad Rubin , Jonathan Berant

Biological systems in nature have evolved for millions of years to adapt and survive the environment. Many features they developed can be inspirational and beneficial for solving technical problems in modern industries. This leads to a…

Computation and Language · Computer Science 2022-04-22 Qihao Zhu , Xinyu Zhang , Jianxi Luo

This paper presents LightLM, a lightweight Transformer-based language model for generative recommendation. While Transformer-based generative modeling has gained importance in various AI sub-fields such as NLP and vision, generative…

Information Retrieval · Computer Science 2023-10-31 Kai Mei , Yongfeng Zhang

Neural methods of molecule property prediction require efficient encoding of structure and property relationship to be accurate. Recent work using graph algorithms shows limited generalization in the latent molecule encoding space. We build…

Quantitative Methods · Quantitative Biology 2020-11-26 Prateeth Nayak , Andrew Silberfarb , Ran Chen , Tulay Muezzinoglu , John Byrnes

Task planning can require defining myriad domain knowledge about the world in which a robot needs to act. To ameliorate that effort, large language models (LLMs) can be used to score potential next actions during task planning, and even…

Prompt tuning (PT) offers a cost-effective alternative to fine-tuning large-scale pre-trained language models (PLMs), requiring only a few parameters in soft prompt tokens added before the input text. However, existing PT approaches face…

Computation and Language · Computer Science 2025-02-19 Pengxiang Lan , Haoyu Xu , Enneng Yang , Yuliang Liang , Guibing Guo , Jianzhe Zhao , Xingwei Wang

Probing Pre-trained Language Models (PLMs) using prompts has indirectly implied that language models (LMs) can be treated as knowledge bases. To this end, this phenomena has been effective especially when these LMs are fine-tuned towards…

Computation and Language · Computer Science 2022-04-08 M. Abaho , D. Bollegala , P. Williamson , S. Dodd