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This work presents a framework for modeling three-dimensional scaffold-mediated bone regeneration and the associated optimization problem. By incorporating microstructure into the model through periodic homogenization, we capture the…

Numerical Analysis · Mathematics 2025-03-25 Patrick Dondl , Oliver Suchan

In situ polymerization and micropatterning of hydrogels on-chip opens the potential for many applications such as tracking and controlling the diffusion of molecules, stimulants, inhibitors, as well as nutrients and drugs, from their source…

Micro-structured materials consisting of an array of microstructures are engineered to provide the specific material properties. This present work investigates the design of cellular materials under the framework of level set, so as to…

Computational Engineering, Finance, and Science · Computer Science 2018-11-13 Jie Gao , Hao Li , Zhen Luo , Liang Gao , Peigen Li

Living tissues show an extraordinary adaptiveness to strain, which is crucial for their proper biological functioning. The physical origin of this mechanical behaviour has been widely investigated using reconstituted networks of collagen…

Soft Condensed Matter · Physics 2019-02-25 Federica Burla , Justin Tauber , Simone Dussi , Jasper van der Gucht , Gijsje H. Koenderink

The shapes of liquid polystyrene (PS) droplets on viscoelastic polydimethylsiloxane (PDMS) substrates are investigated experimentally using atomic force microscopy for a range of droplet sizes and substrate elasticities. These shapes, which…

Soft Condensed Matter · Physics 2024-12-24 Khalil Remini , Leonie Schmeller , Dirk Peschka , Barbara Wagner , Ralf Seemann

Star block copolymers (s-BCPs) have potential applications as novel surfactants or amphiphiles for emulsification, compatbilization, chemical transformations and separations. s-BCPs are star-shaped macromolecules comprised of linear chains…

A novel modelling technique using finite element analysis to mimic the mechanoresponse of cell-laden biomaterial is proposed for the use in bioinks and other tissue engineering applications. Here a hydrogel-based composite biomaterial…

Materials Science · Physics 2022-10-25 Abhinaba Banerjee , Sudipto Datta , Amit Roy Chowdhury , Pallab Datta

We engineered a microfluidic platform to study the effects of bioactive glass nanoparticles (BGNs) on cell viability under static culture. We incorporated different concentrations of BGNs (1%, 2%, and 3% w/v) in collagen hydrogel (with a…

Tissues and Organs · Quantitative Biology 2024-08-07 Faezeh Ghobadi , Maryam Saadatmand , Sara Simorgh , Peiman Brouki Milan

Micropatterned substrates are often used to standardize cell experiments and to quantitatively study the relation between cell shape and function. Moreover, they are increasingly used in combination with traction force microscopy on soft…

Cell Behavior · Quantitative Biology 2015-06-19 Philipp J. Albert , Ulrich S. Schwarz

In many natural multi-layered composites, such as in the dactyl club of Stomatopods or the shell of bivalve mollusks, the defining functional and structural properties are determined by locally varying orientations of inorganic building…

Soft Condensed Matter · Physics 2018-08-07 Hortense Le Ferrand , Florian Bouville , André R. Studart

The alignment of fibers and cells in living tissues affect their mechanical properties and functionality. In this context, one can draw an analogy between tissues and nematic liquid crystal elastomers. We explore this analogy by growing…

Soft Condensed Matter · Physics 2025-10-08 Kirsten Endresen , Aniruddh Murali , Birte Geerds , Daniel J. G. Pearce , Francesca Serra

We have demonstrated the fabrication and characterization of 2D liquid-based multimode optical waveguide structures over a Polydimethylsiloxane (PDMS) material-based chip. Fabrication of two separate microstructures, one with a width of 14…

Optics · Physics 2023-01-27 Sanyogita , Amar Ghar , P. K. Panigrahi

Two-dimensional transition metal chalcogenides, with their atomically layered structure, favourable electronic and mechanical properties, and often strong spin-orbit coupling, are ideal systems for fundamental studies and for applications…

Materials Science · Physics 2025-09-30 A. Rajan , M. Ramirez , N. Kushwaha , S. Buchberger , M. McLaren , P. D. C. King

We report the development of magnetic nanocomposite sheets with superhydrophobic and superoleophilic surfaces generated by laser ablation. Polydimethylsiloxane elastomer freestanding films, loaded homogeneously with 2% wt. carbon coated…

Polydimethylsiloxane (PDMS) films possess different chemical and physical properties based on surface modification. The bond structure of pristine PDMS films and plasma treated PDMS films differ in a particular region of silicate bonds. We…

Applied Physics · Physics 2017-07-10 Amit R. Morarka , Aditee C. Joshi

Functionality of living cells is inherently linked to subunits with dimensions on the nanoscale. In case of osteoblasts the cell surface plays a particularly important role for adhesion and spreading which are crucial properties with regard…

Biological Physics · Physics 2020-11-30 C. Voelkner , M. Wendt , R. Lange , M. Ulbrich , M. Gruening , S. Staehlke , J. B. Nebe , I. Barke , S. Speller

The methodologies of bioinspiration, biomimetics, and bioreplication are inevitably pointing to the incorporation of multifunctionality in engineered materials when designing ever more complex systems. Optimal multifunctionality is also the…

Optics · Physics 2015-08-18 Akhlesh Lakhtakia

The interfacial structures and interactions of two-dimensional (2D) materials on solid substrates are of fundamental importance for the fabrication and application of 2D materials. However, selection of a suitable solid substrate to grow 2D…

Materials Science · Physics 2021-06-16 Xian-Li Zhang , Jinbo Pan , Xin Jin , Yan-Fang Zhang , Jia-Tao Sun , Yu-Yang Zhang , Shixuan Du

The clinical need for vascular grafts is associated with cardiovascular diseases frequently leading to fatal outcomes. Artificial vessels based on bioresorbable polymers can replace the damaged vascular tissue or create a bypass path for…

Recent surveys have shown that the number of nanoparticle-based formulations actually used at the clinical level is significantly lower than expected a decade ago. One reason for this is that the nanoparticle physicochemical properties fall…

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