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Accurate diagnosis of pediatric brain tumors, starting with histopathology, presents unique challenges for deep learning, including severe data scarcity, class imbalance, and fine-grained morphologic overlap across diagnostically distinct…
Affine image registration is a cornerstone of medical image analysis. While classical algorithms can achieve excellent accuracy, they solve a time-consuming optimization for every image pair. Deep-learning (DL) methods learn a function that…
Graph-based semi-supervised learning has been shown to be one of the most effective approaches for classification tasks from a wide range of domains, such as image classification and text classification, as they can exploit the connectivity…
We introduce "PatchMorph," an new stochastic deep learning algorithm tailored for unsupervised 3D brain image registration. Unlike other methods, our method uses compact patches of a constant small size to derive solutions that can combine…
Deep learning based disease detection and segmentation algorithms promise to improve many clinical processes. However, such algorithms require vast amounts of annotated training data, which are typically not available in the medical context…
Whole brain extraction, also known as skull stripping, is a process in neuroimaging in which non-brain tissue such as skull, eyeballs, skin, etc. are removed from neuroimages. Skull striping is a preliminary step in presurgical planning,…
Evaluation of hydrocephalus in children is challenging, and the related research is limited by a lack of publicly available, expert-annotated datasets, particularly those with segmentation of the choroid plexus. To address this, we present…
Spiking neural networks are motivated from principles of neural systems and may possess unexplored advantages in the context of machine learning. A class of \textit{convolutional spiking neural networks} is introduced, trained to detect…
Brain tumor segmentation is important for diagnosis of the tumor, and current deep-learning methods rely on a large set of annotated images for training, with high annotation costs. Unsupervised segmentation is promising to avoid human…
Developing personalized computational models of the human brain remains a challenge for patient-specific clinical applications and neuroscience research. Efficient and accurate biophysical simulations rely on high-quality personalized…
A key limitation of deep convolutional neural networks (DCNN) based image segmentation methods is the lack of generalizability. Manually traced training images are typically required when segmenting organs in a new imaging modality or from…
Recent advancements in deep learning have shifted the development of brain imaging analysis. However, several challenges remain, such as heterogeneity, individual variations, and the contradiction between the high dimensionality and small…
Purpose: The goal of this work was to develop a deep network for whole-head segmentation including clinical MRIs with abnormal anatomy, and compile the first public benchmark dataset for this purpose. We collected 98 MRIs with volumetric…
Deep convolutional neural networks (CNNs) are state-of-the-art for semantic image segmentation, but typically require many labeled training samples. Obtaining 3D segmentations of medical images for supervised training is difficult and labor…
Biological spiking neurons with intrinsic dynamics underlie the powerful representation and learning capabilities of the brain for processing multimodal information in complex environments. Despite recent tremendous progress in spiking…
Advances in image registration and machine learning have recently enabled volumetric analysis of postmortem brain tissue from conventional photographs of coronal slabs, which are routinely collected in brain banks and neuropathology…
Generative AI models hold great potential in creating synthetic brain MRIs that advance neuroimaging studies by, for example, enriching data diversity. However, the mainstay of AI research only focuses on optimizing the visual quality (such…
We present a deep learning strategy that enables, for the first time, contrast-agnostic semantic segmentation of completely unpreprocessed brain MRI scans, without requiring additional training or fine-tuning for new modalities. Classical…
Deep neural networks (DNNs) offer a means of addressing the challenging task of clustering high-dimensional data. DNNs can extract useful features, and so produce a lower dimensional representation, which is more amenable to clustering…
Generative modelling and synthetic data can be a surrogate for real medical imaging datasets, whose scarcity and difficulty to share can be a nuisance when delivering accurate deep learning models for healthcare applications. In recent…