Related papers: Rebuildable biochronometer: inferences and hypothe…
Time-stamped data have been used to estimate the decay half-lives of radioactive 118mSb and 64,66,68Ga nuclei. These nuclei are populated through the reaction 4He (Elab = 32 MeV) + nat In and p (Elab = 10 MeV) + natZn, respectively. The g…
After birth setting up an effective immune system is a major challenge for all living organisms. In this paper we show that this process can be explored by using the age-specific infant death rate as a kind of sensor. This is made possible…
Joint models for longitudinal biomarkers and time-to-event data are widely used in longitudinal studies. Many joint modeling approaches have been proposed to deal with different types of longitudinal biomarkers and survival outcomes.…
Biological oscillators are very diverse but can be classified based on dynamical motifs such as the types of feedback loops present. The S. Elongatus circadian clock is a remarkable phosphorylation-based oscillator that can be reconstituted…
The circadian clocks keeping time of day in many living organisms rely on self-sustained biochemical oscillations which can be entrained by external cues, such as light, to the 24-hour cycle induced by Earth rotation. However, environmental…
This paper proposes an original theory of aging of multicellular organisms. The cells of multicellular organisms, in contrast to unicellular organisms, are burdened with a two- part genome: housekeeping and specialized (multicellular),…
We present models of dormancy in a planktonic culture and in biofilm, and examine the relative advantage of short dormancy versus long dormancy times in each case. Simulations and analyses indicate that in planktonic batch cultures and in…
Molecular circadian clocks, that are found in all nucleated cells of mammals, are known to dictate rhythms of approximately 24 hours (circa diem) to many physiological processes. This includes metabolism (e.g., temperature, hormonal blood…
The biosignatures of life on Earth do not remain static, but change considerably over the planet's habitable lifetime. Earth's future biosphere, much like that of the early Earth, will consist of predominantly unicellular microorganisms due…
Two bottom $\Sigma_b(6097)^\pm$ baryons were observed in the final states $\Lambda_b^0\pi^-$ and $\Lambda_b^0\pi^+$ in $pp$ collision by LHCb collaboration, whose masses and widths were measured. In a $^{3}P_{0}$ model, the strong decay…
This paper proposes an abstract mathematical frame for describing some features of biological time. The key point is that usual physical (linear) representation of time is insufficient, in our view, for the understanding key phenomena of…
Living systems are subject to the arrow of time; from birth, they undergo complex transformations (self-organization) in a constant battle for survival, but inevitably ageing and disease trap them to death. Can ageing be understood and…
Advances in wearable computing and AI have increased interest in leveraging PPG for health monitoring over the past decade. One of the biggest challenges in developing health algorithms based on such biosignals is the sparsity of clinical…
Biological time can be measured in two ways: in generations and in physical (chronological) time. When generations overlap, these two notions diverge, which impedes our ability to relate mathematical models to real populations. In this…
We present new results on the lifetimes and widths of $B$ hadrons based on 300-450 pb$^{-1}$ of data collected by CDF and D{\O}at the Fermilab Tevatron. Lifetimes were measured in semileptonic decays as well as fully reconstructed hadronic…
Unlike most other laws of nature, the second law of thermodynamics is of a statistical nature, according to Boltzmann, meaning that its reliability arises from the vast number of particles present in macroscopic systems. This means that…
We develop and apply a new framework for reconstructing the ionization history during the epoch of recombination with combinations of cosmic microwave background (CMB), baryon acoustic oscillation (BAO) and supernova data. We find a wide…
The Crab Pulsar is known to feature plasma lensing events known as echoes. These events are characterized by additional components in the pulse profile which are produced by additional images formed when the pulsar's radio emission is…
Epigenetics is the study of how people's behavior and environments influence the way their genes are expressed, even though their DNA sequence is itself unchanged. By aggregating age-related epigenetic markers, epigenetic 'clocks' have…
The product of resting heart rate and maximum lifespan is approximately constant across adult warm-blooded vertebrates, $N^\star = f_H L \approx 10^9$ cardiac cycles, a regularity documented since Rubner (1908) but lacking a thermodynamic…