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The evolutionary biology of aging is fundamental to understanding the mechanisms of aging and how to develop anti-aging treatments. Thus far most evolutionary theory concerns the genetics of aging with limited physiological integration.…
We exploit the premises of exceptional points of degeneracy (EPDs) induced in linear time-periodic (LTP) systems to achieve extremely sensitive biosensors. The EPD is formed in a single LC resonator where the total capacitance is comprised…
Physical aging in polymers is a fundamental yet poorly understood phenomenon, as diverse macromolecular systems exhibit remarkably similar slow dynamics. Through molecular dynamics simulations of physically crosslinked networks composed of…
Many organisms possess both a cell cycle to control DNA replication and a circadian clock to anticipate changes between day and night. In some cases, these two rhythmic systems are known to be coupled by specific, cross-regulatory…
Biological age, which may be older or younger than chronological age due to factors such as genetic predisposition, environmental exposures, serves as a meaningful biomarker of aging processes and can inform risk stratification, treatment…
Charged-particle trajectories are usually reconstructed with the LHCb detector using combined information from the tracking devices placed upstream and downstream of the 4\,T\,m dipole magnet. Trajectories reconstructed using only…
We consider isospin predictions for the semi-leptonic and non-leptonic decays of the $\Lambda_b$ baryon. Isospin conservation of the strong interactions constrains the possible final states in $\Lambda_b$ decays. Since the baryon hyperfine…
The study of synchronization in biological systems is essential for the understanding of the rhythmic phenomena of living organisms at both molecular and cellular levels. In this paper, by using simple dynamical systems theory, we present a…
The cyanobacterium Synechococcus elongatus uses both a protein phosphorylation cycle and a transcription-translation cycle to generate circadian rhythms that are highly robust against biochemical noise. We use stochastic simulations to…
In permissive environments, E. coli can double its dry mass every 21 minutes. During this time, ribosomes, RNA polymerases, and the proteome are all doubled. Yet, the question of how to relate bacterial doubling time to other biologically…
Bone remodeling involves the coordinated removal of bone by osteoclasts and addition of bone by osteoblasts, a process that is modulated by the prevailing mechanical environment. In this paper a fully coupled model of bone remodeling is…
How genes affect tissue scale organization remains a longstanding biological puzzle. As experimental efforts aim to quantify gene expression, chromatin organization, cellular structure, and tissue structure, computational modeling lags…
All cells must keep time to consistently perform vital biological functions. To that end, the coupling and interrelatedness of diverse subsecond events in the complex cellular environment, such as protein folding or translation rates,…
We consider an alternative to the standard picture of CV and LMXB evolution, namely the idea that most CVs (and by extension LMXBs) may not yet have had time to evolve to their theoretical minimum orbital periods. We call this the Binary…
Data collected with the BABAR detector at the PEP-II asymmetric B Factory at SLAC are used to study the lifetimes of the B^0 and B^+ mesons. The data sample consists of 7.4 fb-1 collected near the Y(4S) resonance. B^0 and B^+ mesons are…
Life is a complex biological phenomenon represented by numerous chemical, physical and biological processes performed by a biothermodynamic system/cell/organism. Both living organisms and inanimate objects are subject to aging, a biological…
Circadian clocks play a pivotal role in orchestrating numerous physiological and developmental events. Waveform shapes of the oscillations of protein abundances can be informative about the underlying biochemical processes of circadian…
Causal ordering of key events in the cell cycle is essential for proper functioning of an organism. Yet, it remains a mystery how a specific temporal program of events is maintained despite ineluctable stochasticity in the biochemical…
The extinct p-process nuclide 146Sm serves as an astrophysical and geochemical chronometer through measurements of isotopic anomalies of its alpha-decay daughter 142Nd. Based on analyses of 146Sm/147Sm alpha-activity and atom ratios, we…
I report new, world-leading LHCb results on heavy meson lifetimes. We use a novel approach that suppresses the shortcomings typically associated with reconstruction of semileptonic decays, allowing for precise measurements of lifetimes and…