English
Related papers

Related papers: Contextual Molecule Representation Learning from C…

200 papers

Molecular representation learning is pivotal for various molecular property prediction tasks related to drug discovery. Robust and accurate benchmarks are essential for refining and validating current methods. Existing molecular property…

Chemical Physics · Physics 2024-06-27 Shikun Feng , Jiaxin Zheng , Yinjun Jia , Yanwen Huang , Fengfeng Zhou , Wei-Ying Ma , Yanyan Lan

In the field of multi-class anomaly detection, reconstruction-based methods derived from single-class anomaly detection face the well-known challenge of "learning shortcuts", wherein the model fails to learn the patterns of normal samples…

Computer Vision and Pattern Recognition · Computer Science 2024-07-17 Liren He , Zhengkai Jiang , Jinlong Peng , Liang Liu , Qiangang Du , Xiaobin Hu , Wenbing Zhu , Mingmin Chi , Yabiao Wang , Chengjie Wang

Multimodal Large Language Models (MLLMs) have seen growing adoption across various scientific disciplines. These advancements encourage the investigation of molecule-text modeling within synthetic chemistry, a field dedicated to designing…

Machine Learning · Computer Science 2024-06-21 He Cao , Yanjun Shao , Zhiyuan Liu , Zijing Liu , Xiangru Tang , Yuan Yao , Yu Li

We present Pre-trained Machine Reader (PMR), a novel method for retrofitting pre-trained masked language models (MLMs) to pre-trained machine reading comprehension (MRC) models without acquiring labeled data. PMR can resolve the discrepancy…

Computation and Language · Computer Science 2023-10-17 Weiwen Xu , Xin Li , Wenxuan Zhang , Meng Zhou , Wai Lam , Luo Si , Lidong Bing

How to learn discriminative video representation from unlabeled videos is challenging but crucial for video analysis. The latest attempts seek to learn a representation model by predicting the appearance contents in the masked regions.…

Computer Vision and Pattern Recognition · Computer Science 2023-03-24 Xinyu Sun , Peihao Chen , Liangwei Chen , Changhao Li , Thomas H. Li , Mingkui Tan , Chuang Gan

Self-supervised representation learning has achieved remarkable success in recent years. By subverting the need for supervised labels, such approaches are able to utilize the numerous unlabeled images that exist on the Internet and in…

Computer Vision and Pattern Recognition · Computer Science 2021-09-01 Yilun Du , Chuang Gan , Phillip Isola

Graph based molecular representation learning is essential for accurately predicting molecular properties in drug discovery and materials science; however, it faces significant challenges due to the intricate relationships among molecules…

Computational Engineering, Finance, and Science · Computer Science 2025-05-28 Zhengyang Zhou , Yunrui Li , Pengyu Hong , Hao Xu

Chemical language models (CLMs) are prominent for their effectiveness in exploring chemical space and enabling molecular engineering. However, while exploring chemical-linguistic space, CLMs suffer from the gap between natural language and…

Computational Engineering, Finance, and Science · Computer Science 2025-01-07 Liuzhenghao Lv , Hao Li , Yu Wang , Zhiyuan Yan , Zijun Chen , Zongying Lin , Li Yuan , Yonghong Tian

Mask-based pretraining has become a cornerstone of modern large-scale models across language, vision, and recently biology. Despite its empirical success, its role and limits in learning data representations have been unclear. In this work,…

Machine Learning · Computer Science 2025-09-29 Mingze Dong , Leda Wang , Yuval Kluger

We present Recurrent Video Masked-Autoencoders (RVM): a novel approach to video representation learning that leverages recurrent computation to model the temporal structure of video data. RVM couples an asymmetric masking objective with a…

Computer Vision and Pattern Recognition · Computer Science 2026-04-22 Daniel Zoran , Nikhil Parthasarathy , Yi Yang , Drew A Hudson , Joao Carreira , Andrew Zisserman

Molecular representation learning plays an essential role in cheminformatics. Recently, language model-based approaches have gained popularity as an alternative to traditional expert-designed features to encode molecules. However, these…

Machine Learning · Computer Science 2022-04-19 Zhihui Guo , Pramod Sharma , Andy Martinez , Liang Du , Robin Abraham

Self-supervised learning methods like masked autoencoders (MAE) have shown significant promise in learning robust feature representations, particularly in image reconstruction-based pretraining task. However, their performance is often…

Computer Vision and Pattern Recognition · Computer Science 2025-07-31 Sua Lee , Joonhun Lee , Myungjoo Kang

This work considers the task of representation learning on the attributed relational graph (ARG). Both the nodes and edges in an ARG are associated with attributes/features allowing ARGs to encode rich structural information widely observed…

Machine Learning · Computer Science 2022-08-10 Yifei Wang , Shiyang Chen , Guobin Chen , Ethan Shurberg , Hang Liu , Pengyu Hong

We present a novel masked image modeling (MIM) approach, context autoencoder (CAE), for self-supervised representation pretraining. We pretrain an encoder by making predictions in the encoded representation space. The pretraining tasks…

Computer Vision and Pattern Recognition · Computer Science 2023-08-11 Xiaokang Chen , Mingyu Ding , Xiaodi Wang , Ying Xin , Shentong Mo , Yunhao Wang , Shumin Han , Ping Luo , Gang Zeng , Jingdong Wang

Masked Image Modeling (MIM) has emerged as a promising method for deriving visual representations from unlabeled image data by predicting missing pixels from masked portions of images. It excels in region-aware learning and provides strong…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Yibing Wei , Abhinav Gupta , Pedro Morgado

Accurate prediction of recurrence in clear cell renal cell carcinoma (ccRCC) remains a major clinical challenge due to the disease complex molecular, pathological, and clinical heterogeneity. Traditional prognostic models, which rely on…

Image and Video Processing · Electrical Eng. & Systems 2025-07-11 Hasaan Maqsood , Saif Ur Rehman Khan

Multimodal representation learning has shown promising improvements on various vision-language tasks. Most existing methods excel at building global-level alignment between vision and language while lacking effective fine-grained image-text…

Computer Vision and Pattern Recognition · Computer Science 2023-06-16 Zijia Zhao , Longteng Guo , Xingjian He , Shuai Shao , Zehuan Yuan , Jing Liu

Organic reaction, the foundation of modern chemical industry, is crucial for new material development and drug discovery. However, deciphering reaction mechanisms and modeling multi-molecular relationships remain formidable challenges due…

Chemical Physics · Physics 2025-08-13 Lirong Wu , Junjie Wang , Zhifeng Gao , Xiaohong Ji , Rong Zhu , Xinyu Li , Linfeng Zhang , Guolin Ke , Weinan E

In recent years, artificial intelligence has played an important role on accelerating the whole process of drug discovery. Various of molecular representation schemes of different modals (e.g. textual sequence or graph) are developed. By…

Machine Learning · Computer Science 2022-11-28 Tianyu Wu , Yang Tang , Qiyu Sun , Luolin Xiong

Radiology Report Generation (RRG) is essential for computer-aided diagnosis and medication guidance, which can relieve the heavy burden of radiologists by automatically generating the corresponding radiology reports according to the given…

Computer Vision and Pattern Recognition · Computer Science 2025-05-30 Weixing Chen , Yang Liu , Ce Wang , Jiarui Zhu , Guanbin Li , Cheng-Lin Liu , Liang Lin