English
Related papers

Related papers: Contextual Molecule Representation Learning from C…

200 papers

Molecular representation learning (MRL) is a fundamental task for drug discovery. However, previous deep-learning (DL) methods focus excessively on learning robust inner-molecular representations by mask-dominated pretraining framework,…

Biomolecules · Quantitative Biology 2023-06-16 Yu Wang , JingJie Zhang , Junru Jin , Leyi Wei

Molecule representation learning (MRL) methods aim to embed molecules into a real vector space. However, existing SMILES-based (Simplified Molecular-Input Line-Entry System) or GNN-based (Graph Neural Networks) MRL methods either take…

Machine Learning · Computer Science 2021-09-23 Hongwei Wang , Weijiang Li , Xiaomeng Jin , Kyunghyun Cho , Heng Ji , Jiawei Han , Martin D. Burke

Molecular representation learning (MRL) is a key step to build the connection between machine learning and chemical science. In particular, it encodes molecules as numerical vectors preserving the molecular structures and features, on top…

Quantitative Methods · Quantitative Biology 2023-11-30 Zhichun Guo , Kehan Guo , Bozhao Nan , Yijun Tian , Roshni G. Iyer , Yihong Ma , Olaf Wiest , Xiangliang Zhang , Wei Wang , Chuxu Zhang , Nitesh V. Chawla

Inspired by the recent success of sequence modeling in RL and the use of masked language model for pre-training, we propose a masked model for pre-training in RL, RePreM (Representation Pre-training with Masked Model), which trains the…

Machine Learning · Computer Science 2023-03-06 Yuanying Cai , Chuheng Zhang , Wei Shen , Xuyun Zhang , Wenjie Ruan , Longbo Huang

Recent advances in molecular representation integrates molecular topological and visual modalities, opening new avenues for precise Molecular Relational Learning (MRL). Existing MRL methods focus on intra-domain modeling, and their inherent…

Machine Learning · Computer Science 2026-05-25 Peiliang Zhang , Jingling Yuan , Shiqing Wu , Mengqing Hu , Chao Che , Yongjun Zhu , Lin Li

Context-aware methods have achieved remarkable advancements in supervised scene text recognition by leveraging semantic priors from words. Considering the heterogeneity of text and background in STR, we propose that such contextual priors…

Computer Vision and Pattern Recognition · Computer Science 2024-11-20 Tiancheng Lin , Jinglei Zhang , Yi Xu , Kai Chen , Rui Zhang , Chang-Wen Chen

Modern studies in radiograph representation learning rely on either self-supervision to encode invariant semantics or associated radiology reports to incorporate medical expertise, while the complementarity between them is barely noticed.…

Computer Vision and Pattern Recognition · Computer Science 2023-02-16 Hong-Yu Zhou , Chenyu Lian , Liansheng Wang , Yizhou Yu

Chemical representation learning has gained increasing interest due to the limited availability of supervised data in fields such as drug and materials design. This interest particularly extends to chemical language representation learning,…

Chemical Physics · Physics 2024-08-06 Jun-Hyung Park , Yeachan Kim , Mingyu Lee , Hyuntae Park , SangKeun Lee

Multimodal representation learning has been largely driven by contrastive models such as CLIP, which learn a shared embedding space by aligning paired image-text samples. While effective for general-purpose representation learning, such…

Machine Learning · Computer Science 2026-05-12 Yang Qiao , Yuntong Hu , Bowen Zhu , Hasibul Haque , Liang Zhao

Nuclear magnetic resonance (NMR) spectroscopy provides an experimental readout of local chemical environments, but its use in molecular representation learning has been constrained by heterogeneous data and incomplete atom-level…

Chemical Physics · Physics 2026-05-12 Jiebin Fang , Zidi Yan , Churu Mao , Yongjun Jiang , Xinyi Tang , Lei Miao , Dan Lu , Yun Huang , Wanjing Ding , Zhongjun Ma

Chemical reaction prediction is pivotal for accelerating drug discovery and synthesis planning. Despite advances in data-driven models, current approaches are hindered by an overemphasis on parameter and dataset scaling. Some methods…

Machine Learning · Computer Science 2026-03-04 Ran Li , Shimin Di , Haowei LI , Luanshi Bu , Jiachuan Wang , Wangze Ni , Lei Chen

We present a novel self-supervised approach for representation learning, particularly for the task of Visual Relationship Detection (VRD). Motivated by the effectiveness of Masked Image Modeling (MIM), we propose Masked Bounding Box…

Computer Vision and Pattern Recognition · Computer Science 2023-11-09 Zacharias Anastasakis , Dimitrios Mallis , Markos Diomataris , George Alexandridis , Stefanos Kollias , Vassilis Pitsikalis

For deep reinforcement learning (RL) from pixels, learning effective state representations is crucial for achieving high performance. However, in practice, limited experience and high-dimensional inputs prevent effective representation…

Machine Learning · Computer Science 2022-10-11 Tao Yu , Zhizheng Zhang , Cuiling Lan , Yan Lu , Zhibo Chen

Prediction of complete step-by-step chemical reaction mechanisms (CRMs) remains a major challenge. Whereas the traditional approaches in CRM tasks rely on expert-driven experiments or costly quantum chemical computations, contemporary deep…

Chemical Physics · Physics 2025-12-11 Manajit Das , Ajnabiul Hoque , Mayank Baranwal , Raghavan B. Sunoj

Molecular Representation Learning (MRL) has proven impactful in numerous biochemical applications such as drug discovery and enzyme design. While Graph Neural Networks (GNNs) are effective at learning molecular representations from a 2D…

Recent works in self-supervised learning have demonstrated strong performance on scene-level dense prediction tasks by pretraining with object-centric or region-based correspondence objectives. In this paper, we present Region-to-Object…

Computer Vision and Pattern Recognition · Computer Science 2022-12-22 Akash Gokul , Konstantinos Kallidromitis , Shufan Li , Yusuke Kato , Kazuki Kozuka , Trevor Darrell , Colorado J Reed

Masked image modeling has been demonstrated as a powerful pretext task for generating robust representations that can be effectively generalized across multiple downstream tasks. Typically, this approach involves randomly masking patches…

Computer Vision and Pattern Recognition · Computer Science 2024-02-29 Neelu Madan , Nicolae-Catalin Ristea , Kamal Nasrollahi , Thomas B. Moeslund , Radu Tudor Ionescu

Optical chemical structure recognition (OCSR) translates molecular images into machine-readable representations like SMILES strings or molecular graphs, but remains challenging in real-world documents due to inexhaustible variations in…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Zhuoqi Lyu , Qing Ke

Molecular Relational Learning (MRL) is widely applied in natural sciences to predict relationships between molecular pairs by extracting structural features. The representational similarity between substructure pairs determines the…

Machine Learning · Computer Science 2026-05-25 Peiliang Zhang , Jingling Yuan , Qing Xie , Yongjun Zhu , Lin Li

Masked Autoencoders (MAE) have been popular paradigms for large-scale vision representation pre-training. However, MAE solely reconstructs the low-level RGB signals after the decoder and lacks supervision upon high-level semantics for the…

Computer Vision and Pattern Recognition · Computer Science 2023-03-10 Peng Gao , Renrui Zhang , Rongyao Fang , Ziyi Lin , Hongyang Li , Hongsheng Li , Qiao Yu
‹ Prev 1 2 3 10 Next ›