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Drug discovery can be viewed as a combinatorial search over an immense chemical space, motivating the development of deep generative models for de novo molecular design. Among these, GPT-based molecular language models (MLM) have shown…

Machine Learning · Computer Science 2026-02-02 Qianwei Yang , Dong Xu , Zhangfan Yang , Sisi Yuan , Zexuan Zhu , Jianqiang Li , Junkai Ji

Discrete diffusion models have recently emerged as strong alternatives to autoregressive language models, matching their performance through large-scale training. However, inference-time control remains relatively underexplored. In this…

Machine Learning · Computer Science 2026-04-09 Meihua Dang , Jiaqi Han , Minkai Xu , Kai Xu , Akash Srivastava , Stefano Ermon

Diffusion Language Models (DLMs) offer a promising alternative for language modeling by enabling parallel decoding through iterative refinement. However, most DLMs rely on hard binary masking and discrete token assignments, which hinder the…

Computation and Language · Computer Science 2026-01-19 Linhao Zhong , Linyu Wu , Bozhen Fang , Tianjian Feng , Chenchen Jing , Wen Wang , Jiaheng Zhang , Hao Chen , Chunhua Shen

Generative AI presents chemists with novel ideas for drug design and facilitates the exploration of vast chemical spaces. Diffusion models (DMs), an emerging tool, have recently attracted great attention in drug R\&D. This paper…

Biomolecules · Quantitative Biology 2025-07-14 Peining Zhang , Daniel Baker , Minghu Song , Jinbo Bi

Diffusion Language Models (DLMs) have emerged as a promising alternative to Autoregressive Language Models, yet their inference strategies remain limited to prefix-based prompting inherited from the autoregressive paradigm. In this paper,…

Computation and Language · Computer Science 2026-05-19 Junhoo Lee , Seungyeon Kim , Nojun Kwak

Large Language Models (LLMs) have achieved state-of-the-art performance on a broad range of Natural Language Processing (NLP) tasks, including document processing and code generation. Autoregressive Language Models (ARMs), which generate…

Steering language model generation toward desired textual properties is essential for practical deployment, and inference-time methods are particularly appealing because they enable controllable generation without retraining. Recent work…

Computation and Language · Computer Science 2026-05-29 Hyeseon An , Yo-Sub Han

In recent years, large language models (LLMs) have witnessed remarkable advancements, with the test-time scaling law consistently enhancing the reasoning capabilities. Through systematic evaluation and exploration of a diverse spectrum of…

Computation and Language · Computer Science 2025-11-03 Chenyang Shao , Sijian Ren , Fengli Xu , Yong Li

Latent diffusion models offer an attractive alternative to discrete diffusion for non-autoregressive text generation by operating on continuous text representations and denoising entire sequences in parallel. The major challenge in latent…

Computation and Language · Computer Science 2026-05-11 Viacheslav Meshchaninov , Alexander Shabalin , Egor Chimbulatov , Nikita Gushchin , Ilya Koziev , Alexander Korotin , Dmitry Vetrov

Diffusion language models promise parallel generation, yet still lag behind autoregressive (AR) models in quality. We stem this gap to a failure of introspective consistency: AR models agree with their own generations, while DLMs often do…

Diffusion Probabilistic Models (DPMs) have demonstrated significant potential in 3D medical image segmentation tasks. However, their high computational cost and inability to fully capture global 3D contextual information limit their…

Image and Video Processing · Electrical Eng. & Systems 2025-04-17 Kangbo Ma

Autoregressive language models (ARMs) deliver strong likelihoods, but are inherently serial: they generate one token per forward pass, which limits throughput and inflates latency for long sequences. Diffusion Language Models (DLMs)…

Computation and Language · Computer Science 2026-04-14 Amin Karimi Monsefi , Nikhil Bhendawade , Manuel Rafael Ciosici , Dominic Culver , Yizhe Zhang , Irina Belousova

Early DNA foundation models adopted BERT-style training, achieving good performance on DNA understanding tasks but lacking generative capabilities. Recent autoregressive models enable DNA generation, but employ left-to-right causal modeling…

Machine Learning · Computer Science 2026-03-03 Zhao Yang , Hengchang Liu , Chuan Cao , Bing Su

Diffusion-based large language models (dLLMs) have exhibited substantial potential for parallel text generation, which may enable more efficient generation compared to autoregressive models. However, current dLLMs suffer from fixed…

Computation and Language · Computer Science 2025-10-29 Yicun Yang , Cong Wang , Shaobo Wang , Zichen Wen , Biqing Qi , Hanlin Xu , Linfeng Zhang

Recently, diffusion models have excelled in image generation tasks and have also been applied to neural language processing (NLP) for controllable text generation. However, the application of diffusion models in a cross-lingual setting is…

Computation and Language · Computer Science 2023-08-01 Linyao Chen , Aosong Feng , Boming Yang , Zihui Li

Unified architectures in multimodal large language models (MLLM) have shown promise in handling diverse tasks within a single framework. In the text-to-speech (TTS) task, current MLLM-based approaches rely on discrete token representations,…

Audio and Speech Processing · Electrical Eng. & Systems 2025-10-27 Xinlu He , Swayambhu Nath Ray , Harish Mallidi , Jia-Hong Huang , Ashwin Bellur , Chander Chandak , M. Maruf , Venkatesh Ravichandran

Diffusion language models (DLMs) are an attractive alternative to autoregressive models because they promise sublinear-time, parallel generation, yet practical gains remain elusive as high-quality samples still demand hundreds of refinement…

Machine Learning · Computer Science 2026-05-04 Hasan Amin , Yuan Gao , Yaser Souri , Subhojit Som , Ming Yin , Rajiv Khanna , Xia Song

We introduce the hfut-lmc team's solution to the SLRTP Sign Production Challenge. The challenge aims to generate semantically aligned sign language pose sequences from text inputs. To this end, we propose a Text-driven Diffusion Model (TDM)…

Computer Vision and Pattern Recognition · Computer Science 2025-03-21 Jiayi He , Xu Wang , Ruobei Zhang , Shengeng Tang , Yaxiong Wang , Lechao Cheng

Large Language Models (LLMs) have made great strides in areas such as language processing and computer vision. Despite the emergence of diverse techniques to improve few-shot learning capacity, current LLMs fall short in handling the…

Biomolecules · Quantitative Biology 2024-05-14 Xianggen Liu , Yan Guo , Haoran Li , Jin Liu , Shudong Huang , Bowen Ke , Jiancheng Lv

Recent Speech Large Language Models~(LLMs) have achieved impressive capabilities in end-to-end speech interaction. However, the prevailing autoregressive paradigm imposes strict serial constraints, limiting generation efficiency and…

Computation and Language · Computer Science 2026-02-10 Ziyang Cheng , Yuhao Wang , Heyang Liu , Ronghua Wu , Qunshan Gu , Yanfeng Wang , Yu Wang