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Modern AI models are typically trained on static datasets, limiting their ability to continuously adapt to rapidly evolving real-world environments. While continual learning (CL) addresses this limitation, most CL methods are designed for…

Machine Learning · Computer Science 2026-03-16 Gyutae Oh , Jitae Shin

Reliable identification of molecular biomarkers is essential for accurate patient stratification. While state-of-the-art machine learning approaches for sample classification continue to push boundaries in terms of performance, most of…

Molecular Networks · Quantitative Biology 2019-11-07 Matteo Manica , Joris Cadow , Roland Mathis , María Rodríguez Martínez

Cancer is a leading cause of death worldwide, necessitating advancements in early detection and treatment technologies. In this paper, we present a novel and highly efficient melanoma detection framework that synergistically combines the…

Image and Video Processing · Electrical Eng. & Systems 2024-08-05 Peng Zhang , Divya Chaudhary

Deep learning for medical imaging is hampered by task-specific models that lack generalizability and prognostic capabilities, while existing 'universal' approaches suffer from simplistic conditioning and poor medical semantic understanding.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Numan Saeed , Tausifa Jan Saleem , Fadillah Maani , Muhammad Ridzuan , Hu Wang , Mohammad Yaqub

The field of computational pathology has witnessed great advancements since deep neural networks have been widely applied. These networks usually require large numbers of annotated data to train vast parameters. However, it takes…

Computer Vision and Pattern Recognition · Computer Science 2022-08-11 Yixiao Zhang , Adam Kortylewski , Qing Liu , Seyoun Park , Benjamin Green , Elizabeth Engle , Guillermo Almodovar , Ryan Walk , Sigfredo Soto-Diaz , Janis Taube , Alex Szalay , Alan Yuille

Blood cell classification and counting are vital for the diagnosis of various blood-related diseases, such as anemia, leukemia, and thrombocytopenia. The manual process of blood cell classification and counting is time-consuming, prone to…

Image and Video Processing · Electrical Eng. & Systems 2024-05-27 Sohag Kumar Mondal , Md. Simul Hasan Talukder , Mohammad Aljaidi , Rejwan Bin Sulaiman , Md Mohiuddin Sarker Tushar , Amjad A Alsuwaylimi

Pathology Foundation Models (FMs) have shown strong performance across a wide range of pathology image representation and diagnostic tasks. However, FMs do not exhibit the expected performance advantage over traditional specialized models…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Zijiang Yang , Chen Kuang , Dongmei Fu

Object segmentation is an important step in the workflow of computational pathology. Deep learning based models generally require large amount of labeled data for precise and reliable prediction. However, collecting labeled data is…

Computer Vision and Pattern Recognition · Computer Science 2020-07-08 Navid Alemi Koohbanani , Mostafa Jahanifar , Neda Zamani Tajadin , Nasir Rajpoot

Nucleus segmentation and classification are the prerequisites in the workflow of digital pathology processing. However, it is very challenging due to its high-level heterogeneity and wide variations. This work proposes a deep neural network…

Image and Video Processing · Electrical Eng. & Systems 2022-12-07 Sen Yang , Jinxi Xiang , Xiyue Wang

Histopathological images are widely used for the analysis of diseased (tumor) tissues and patient treatment selection. While the majority of microscopy image processing was previously done manually by pathologists, recent advances in…

Image and Video Processing · Electrical Eng. & Systems 2024-07-12 Andrey Ignatov , Josephine Yates , Valentina Boeva

Single-cell RNA sequencing (scRNA-seq) enables the study of cellular diversity at single cell level. It provides a global view of cell-type specification during the onset of biological mechanisms such as developmental processes and human…

Machine Learning · Computer Science 2025-11-05 Muhammad Umar , Andras Lakatos , Muhammad Asif , Arif Mahmood

Label-free single-cell imaging offers a scalable, non-invasive alternative to fluorescence-based cytometry, yet inferring molecular phenotypes directly from bright-field morphology remains challenging. We present a unified Deep Learning…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Saqib Nazir , Ardhendu Behera

This paper addresses the task of nuclei segmentation in high-resolution histopathological images. We propose an auto- matic end-to-end deep neural network algorithm for segmenta- tion of individual nuclei. A nucleus-boundary model is…

Computer Vision and Pattern Recognition · Computer Science 2020-03-18 Yuxin Cui , Guiying Zhang , Zhonghao Liu , Zheng Xiong , Jianjun Hu

Single-cell datasets often lack individual cell labels, making it challenging to identify cells associated with disease. To address this, we introduce Mixture Modeling for Multiple Instance Learning (MMIL), an expectation maximization…

Quantitative Methods · Quantitative Biology 2024-06-13 Erin Craig , Timothy Keyes , Jolanda Sarno , Maxim Zaslavsky , Garry Nolan , Kara Davis , Trevor Hastie , Robert Tibshirani

Dataset distillation (DD) has emerged as a promising approach to compress datasets and speed up model training. However, the underlying connections among various DD methods remain largely unexplored. In this paper, we introduce UniDD, a…

Computer Vision and Pattern Recognition · Computer Science 2026-03-16 Deyu Bo , Songhua Liu , Xinchao Wang

Long-horizon robotic tasks are hard due to continuous state-action spaces and sparse feedback. Symbolic world models help by decomposing tasks into discrete predicates that capture object properties and relations. Existing methods learn…

The detection of nuclei and cells in histology images is of great value in both clinical practice and pathological studies. However, multiple reasons such as morphological variations of nuclei or cells make it a challenging task where…

Computer Vision and Pattern Recognition · Computer Science 2021-06-28 Yibao Sun , Xingru Huang , Huiyu Zhou , Qianni Zhang

Digital pathology is one of the most significant developments in modern medicine. Pathological examinations are the gold standard of medical protocols and play a fundamental role in diagnosis. Recently, with the advent of digital scanners,…

Image and Video Processing · Electrical Eng. & Systems 2021-12-09 Mahdi Arab Loodaricheh , Nader Karimi , Shadrokh Samavi

Drug discovery is crucial for identifying candidate drugs for various diseases.However, its low success rate often results in a scarcity of annotations, posing a few-shot learning problem. Existing methods primarily focus on single-scale…

Machine Learning · Computer Science 2025-02-19 Ruifeng Li , Mingqian Li , Wei Liu , Yuhua Zhou , Xiangxin Zhou , Yuan Yao , Qiang Zhang , Hongyang Chen

Molecular Dynamics (MD) simulations are essential for understanding the atomic-level behavior of molecular systems, giving insights into their transitions and interactions. However, classical MD techniques are limited by the trade-off…

Biomolecules · Quantitative Biology 2026-04-21 Ziyang Yu , Wenbing Huang , Yang Liu