Related papers: Efficient multiphoton microscopy with picosecond l…
Many experiments in biological and medical sciences currently use multiphoton microscopy as a core imaging technique. To date, solid-state lasers are most commonly used as excitation beam sources. However, the most demanding applications…
Two-photon microscopy (TPM) enables deep tissue imaging but requires excitation pulses that have a large product of average and peak power, typically supplied by femtosecond solid-state lasers. However, these lasers are bulky and…
Multiphoton microscopy has enabled us to image cellular dynamics in vivo. However, the excitation wavelength for imaging with commercially available lasers is mostly limited between 650-1040 nm. Here we develop a femtosecond fiber laser…
Multiphoton microscopy is widely used for live imaging. However, its acquisition speed remains limited by fluorophore emission rates and photodamage. To increase the pixel rate of a two-photon microscope beyond a few megahertz (MHz),…
A rapid and efficient photo-bleaching process was demonstrated with a high-energy nanosecond pulse to recover existing and/or revealed color centers on 10 kGy Gamma-irradiated Yb-doped optical fiber. Multi-mJ pulsed laser based on an…
A femtosecond frequency-doubled Erbium-doped fiber laser with adjustable pulse repetition rate is developed and applied in two-photon excited fluorescence microscopy. The all-fiber laser system provides the fundamental pulse at 1560 nm…
Advancing ultrafast high-repetition-rate lasers to shortest pulse durations comprising only a few optical cycles while pushing their energy into the multi-millijoule regime opens a route towards terawatt-class peak powers at unprecedented…
Multi-photon microscopy has played a significant role in biological imaging since it allows to observe living tissues with improved penetration depth and excellent sectioning effect. Multi-photon microscopy relies on multi-photon…
We demonstrate a compact scheme for generating sub-20-fs pulses from a commercial ytterbium femtosecond laser delivering 80 fs pulses at 76 MHz repetition rate with 1 W average power. Spectral broadening is achieved in a photonic crystal…
Femtosecond laser pulses enable the synthesis of light across the electromagnetic spectrum and provide access to ultrafast phenomena in physics, biology, and chemistry. Chip-integration of femtosecond technology could revolutionize…
Integrated femtosecond pulse and frequency comb sources are critical components for a wide range of applications. The leading approaches for on-chip pulse generation rely on mode locking inside microresonator with either third-order…
We present a high efficiency source of picosecond pulses derived from a dual cavity optical frequency comb generator. This approach overcomes the limitations of single cavity comb generators that are restricted to efficiencies of a few…
In this work, we demonstrate post-compression of 1.2 picosecond laser pulses to 13 fs via gas-based multi-pass spectral broadening. Our results yield a single-stage compression factor of about 40 at 200 W in-burst average power and a total…
Multi-photon microscopy is a powerful tool in biomolecular research. Less complex and more cost effective excitation light sources will make this technique accessible to a broader community. Especially semiconductor diode seeded fiber…
The next generation of lithography machines uses extreme ultraviolet (EUV) light originating from laser-produced plasma (LPP) sources, where a small tin droplet is ionized by an intense laser pulse to emit the requested light at 13.5 nm.…
Using GHz repetition rate pulses in burst mode has demonstrated numerous advantages for highly efficient material removal. In this work, we present high-speed (over 100 kHz) micro-laser-induced breakdown spectroscopy (micro-LIBS) with…
We demonstrate a remarkably effective single-stage compression technique for ultrafast pulses in the visible electromagnetic spectrum using second-harmonic pulses at 515 nmderived from a 1030 nm Yb-based femtosecond regenerative amplifier.…
To investigate the physics of picosecond gain-switching dynamics in single-mode lasers under femtosecond optical pumping at room temperature, we designed and fabricated first-order surface-grating GaAs distributed-feedback (DFB) lasers with…
We demonstrate an all-fiber mode-locked laser at all-normal dispersion with a saturable absorber, which is based on a section of grade-index multimode fiber with inner microcavity embedded in the splice points. The absorption modulation…
Photoacoustic imaging has emerged in the past decades. Compared with the traditional medical imaging mode, it has better imaging performance and has great development potential in the field of biological imaging. In traditional…