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The use of machine learning (ML) techniques in the biomedical field has become increasingly important, particularly with the large amounts of data generated by the aftermath of the COVID-19 pandemic. However, due to the complex nature of…

Machine Learning · Computer Science 2023-03-17 Anthony Onoja , Francesco Raimondi

Interpretability for machine learning models in medical imaging (MLMI) is an important direction of research. However, there is a general sense of murkiness in what interpretability means. Why does the need for interpretability in MLMI…

Machine Learning · Computer Science 2024-04-17 Alan Q. Wang , Batuhan K. Karaman , Heejong Kim , Jacob Rosenthal , Rachit Saluja , Sean I. Young , Mert R. Sabuncu

Identifying important biomarkers that are predictive for cancer patients' prognosis is key in gaining better insights into the biological influences on the disease and has become a critical component of precision medicine. The emergence of…

Methodology · Statistics 2016-03-22 Hyokyoung Grace Hong , Jian Kang , Yi Li

Specialised transformers-based models (such as BioBERT and BioMegatron) are adapted for the biomedical domain based on publicly available biomedical corpora. As such, they have the potential to encode large-scale biological knowledge. We…

Computation and Language · Computer Science 2022-12-22 Oskar Wysocki , Zili Zhou , Paul O'Regan , Deborah Ferreira , Magdalena Wysocka , Dónal Landers , André Freitas

Prostate cancer being one of the frequently diagnosed malignancy in men, the rising demand for biopsies places a severe workload on pathologists. The grading procedure is tedious and subjective, motivating the development of automated…

Computer Vision and Pattern Recognition · Computer Science 2026-03-06 Riddhasree Bhattacharyya , Pallabi Dutta , Sushmita Mitra

We propose a BlackBox Counterfactual Explainer, designed to explain image classification models for medical applications. Classical approaches (e.g., saliency maps) that assess feature importance do not explain "how" imaging features in…

Computer Vision and Pattern Recognition · Computer Science 2022-11-21 Sumedha Singla , Motahhare Eslami , Brian Pollack , Stephen Wallace , Kayhan Batmanghelich

Models often need to be constrained to a certain size for them to be considered interpretable. For example, a decision tree of depth 5 is much easier to understand than one of depth 50. Limiting model size, however, often reduces accuracy.…

Machine Learning · Computer Science 2020-07-02 Abhishek Ghose , Balaraman Ravindran

Understanding why machine learning models behave the way they do empowers both system designers and end-users in many ways: in model selection, feature engineering, in order to trust and act upon the predictions, and in more intuitive user…

Machine Learning · Statistics 2016-06-20 Marco Tulio Ribeiro , Sameer Singh , Carlos Guestrin

Deep neural networks for medical image diagnosis often achieve high predictive accuracy while relying on spurious or clinically irrelevant visual cues, limiting their trustworthiness in practice. Post-hoc explanation methods are widely used…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Zubair Faruqui , Rahul Dubey

In medical imaging, particularly in early disease detection and prognosis tasks, discerning the rationale behind an AI model's predictions is crucial for evaluating the reliability of its decisions. Conventional explanation methods face…

Computer Vision and Pattern Recognition · Computer Science 2024-06-28 Yingying Fang , Zihao Jin , Xiaodan Xing , Simon Walsh , Guang Yang

Diagnosing an inherited disease often requires identifying the pattern of inheritance in a patient's family. We represent family trees with genetic patterns of inheritance using hypergraphs and latent state space models to provide…

Machine Learning · Statistics 2018-12-06 Edmond Cunningham , Dana Schlegel , Andrew DeOrio

Heart disease is the number one killer, and ECGs can assist in the early diagnosis and prevention of deadly outcomes. Accurate ECG interpretation is critical in detecting heart diseases; however, they are often misinterpreted due to a lack…

Machine Learning · Computer Science 2021-10-29 Dharma KC , Chicheng Zhang , Chris Gniady , Parth Sandeep Agarwal , Sushil Sharma

We present an interpretable companion model for any pre-trained black-box classifiers. The idea is that for any input, a user can decide to either receive a prediction from the black-box model, with high accuracy but no explanations, or…

Machine Learning · Statistics 2020-02-12 Danqing Pan , Tong Wang , Satoshi Hara

Interpretability is essential for user trust in real-world anomaly detection applications. However, deep learning models, despite their strong performance, often lack transparency. In this work, we study the interpretability of…

Besides serving as prediction models, classification trees are useful for finding important predictor variables and identifying interesting subgroups in the data. These functions can be compromised by weak split selection algorithms that…

Applications · Statistics 2010-11-03 Wei-Yin Loh

High predictive performance and ease of use and interpretability are important requirements for the applicability of a computer-aided diagnosis (CAD) to human reading studies. We propose a CAD system specifically designed to be more…

Machine Learning · Statistics 2016-06-28 Cristina Gallego-Ortiz , Anne L. Martel

Clinical trials are critical for drug development but often suffer from expensive and inefficient patient recruitment. In recent years, machine learning models have been proposed for speeding up patient recruitment via automatically…

Machine Learning · Computer Science 2023-07-20 Brandon Theodorou , Cao Xiao , Jimeng Sun

The ability to interpret machine learning model decisions is critical in such domains as healthcare, where trust in model predictions is as important as their accuracy. Inspired by the development of prototype parts-based deep neural…

Machine Learning · Computer Science 2026-03-06 Jacek Karolczak , Jerzy Stefanowski

Deep Learning has shown outstanding results in computer vision tasks; healthcare is no exception. However, there is no straightforward way to expose the decision-making process of DL models. Good accuracy is not enough for skin cancer…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Rosa Y. G. Paccotacya-Yanque , Alceu Bissoto , Sandra Avila

Explainable AI consists in developing mechanisms allowing for an interaction between decision systems and humans by making the decisions of the formers understandable. This is particularly important in sensitive contexts like in the medical…

Image and Video Processing · Electrical Eng. & Systems 2023-02-08 Carlo Metta , Riccardo Guidotti , Yuan Yin , Patrick Gallinari , Salvatore Rinzivillo