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Large language models (LLMs) are rapidly transforming various domains, including biomedicine and healthcare, and demonstrate remarkable potential from scientific research to new drug discovery. Graph-based retrieval-augmented generation…

Quantitative Methods · Quantitative Biology 2025-11-14 Guofeng Meng , Li Shen , Qiuyan Zhong , Wei Wang , Haizhou Zhang , Xiaozhen Wang

Large language models (LLMs) have demonstrated remarkable capabilities in a wide range of tasks, yet their application to specialized domains remains challenging due to the need for deep expertise. Retrieval-Augmented generation (RAG) has…

Computation and Language · Computer Science 2025-09-30 Qinggang Zhang , Shengyuan Chen , Yuanchen Bei , Zheng Yuan , Huachi Zhou , Zijin Hong , Hao Chen , Yilin Xiao , Chuang Zhou , Junnan Dong , Yi Chang , Xiao Huang

We introduce a novel graph-based Retrieval-Augmented Generation (RAG) framework specifically designed for the medical domain, called \textbf{MedGraphRAG}, aimed at enhancing Large Language Model (LLM) capabilities for generating…

Computer Vision and Pattern Recognition · Computer Science 2024-10-17 Junde Wu , Jiayuan Zhu , Yunli Qi , Jingkun Chen , Min Xu , Filippo Menolascina , Vicente Grau

The vast amount of biomedical information available today presents a significant challenge for investigators seeking to digest, process, and understand these findings effectively. Large Language Models (LLMs) have emerged as powerful tools…

Computation and Language · Computer Science 2024-07-19 Alexander R. Pelletier , Joseph Ramirez , Irsyad Adam , Simha Sankar , Yu Yan , Ding Wang , Dylan Steinecke , Wei Wang , Peipei Ping

Recently, Retrieval-Augmented Generation (RAG) has achieved remarkable success in addressing the challenges of Large Language Models (LLMs) without necessitating retraining. By referencing an external knowledge base, RAG refines LLM…

Artificial Intelligence · Computer Science 2024-09-11 Boci Peng , Yun Zhu , Yongchao Liu , Xiaohe Bo , Haizhou Shi , Chuntao Hong , Yan Zhang , Siliang Tang

Large language models (LLMs) struggle with the factual error during inference due to the lack of sufficient training data and the most updated knowledge, leading to the hallucination problem. Retrieval-Augmented Generation (RAG) has gained…

Information Retrieval · Computer Science 2026-01-22 Zulun Zhu , Tiancheng Huang , Kai Wang , Junda Ye , Xinghe Chen , Siqiang Luo

Large language models (LLMs) have recently become the leading source of answers for users' questions online. Despite their ability to offer eloquent answers, their accuracy and reliability can pose a significant challenge. This is…

Computation and Language · Computer Science 2024-07-09 Bojana Bašaragin , Adela Ljajić , Darija Medvecki , Lorenzo Cassano , Miloš Košprdić , Nikola Milošević

Large Language Models (LLMs) have swiftly emerged as vital resources for different applications in the biomedical and healthcare domains; however, these models encounter issues such as generating inaccurate information or hallucinations.…

Computation and Language · Computer Science 2024-05-06 Mingchen Li , Halil Kilicoglu , Hua Xu , Rui Zhang

The question-answering system for Life science research, which is characterized by the rapid pace of discovery, evolving insights, and complex interactions among knowledge entities, presents unique challenges in maintaining a comprehensive…

Computation and Language · Computer Science 2024-08-15 Chengrui Wang , Qingqing Long , Meng Xiao , Xunxin Cai , Chengjun Wu , Zhen Meng , Xuezhi Wang , Yuanchun Zhou

Large language models (LLM) hold significant potential for applications in biomedicine, but they struggle with hallucinations and outdated knowledge. While retrieval-augmented generation (RAG) is generally employed to address these issues,…

Computation and Language · Computer Science 2025-09-23 Jiwoong Sohn , Yein Park , Chanwoong Yoon , Sihyeon Park , Hyeon Hwang , Mujeen Sung , Hyunjae Kim , Jaewoo Kang

Retrieval Augmented Generation (RAG) is a technique used to augment Large Language Models (LLMs) with contextually relevant, time-critical, or domain-specific information without altering the underlying model parameters. However,…

Information Retrieval · Computer Science 2024-08-20 Laurent Mombaerts , Terry Ding , Adi Banerjee , Florian Felice , Jonathan Taws , Tarik Borogovac

In the field of Material Science, effective information retrieval systems are essential for facilitating research. Traditional Retrieval-Augmented Generation (RAG) approaches in Large Language Models (LLMs) often encounter challenges such…

Information Retrieval · Computer Science 2024-12-03 Radeen Mostafa , Mirza Nihal Baig , Mashaekh Tausif Ehsan , Jakir Hasan

Knowing that the generative capabilities of large language models (LLM) are sometimes hampered by tendencies to hallucinate or create non-factual responses, researchers have increasingly focused on methods to ground generated outputs in…

Information Retrieval · Computer Science 2024-11-20 Sonal Prabhune , Donald J. Berndt

Retrieval-augmented generation (RAG) improves the response quality of large language models (LLMs) by retrieving knowledge from external databases. Typical RAG approaches split the text database into chunks, organizing them in a flat…

Computation and Language · Computer Science 2025-11-18 Boyu Chen , Zirui Guo , Zidan Yang , Yuluo Chen , Junze Chen , Zhenghao Liu , Chuan Shi , Cheng Yang

Large Language Models (LLMs) are adept at generating responses based on information within their context. While this ability is useful for interacting with structured data like code files, another popular method, Retrieval-Augmented…

Computation and Language · Computer Science 2025-10-22 Mihir Gupte , Paolo Giusto , Ramesh S

In knowledge-intensive tasks, especially in high-stakes domains like medicine and law, it is critical not only to retrieve relevant information but also to provide causal reasoning and explainability. Large language models (LLMs) have…

Artificial Intelligence · Computer Science 2025-03-18 Hang Luo , Jian Zhang , Chujun Li

Retrieval-augmented generation (RAG) techniques have emerged as a promising solution to enhance the reliability of large language models (LLMs) by addressing issues like hallucinations, outdated knowledge, and domain adaptation. In…

Computation and Language · Computer Science 2025-01-28 Weihang Su , Yichen Tang , Qingyao Ai , Junxi Yan , Changyue Wang , Hongning Wang , Ziyi Ye , Yujia Zhou , Yiqun Liu

Large Language Models (LLMs) showcase impressive capabilities but encounter challenges like hallucination, outdated knowledge, and non-transparent, untraceable reasoning processes. Retrieval-Augmented Generation (RAG) has emerged as a…

Computation and Language · Computer Science 2024-03-28 Yunfan Gao , Yun Xiong , Xinyu Gao , Kangxiang Jia , Jinliu Pan , Yuxi Bi , Yi Dai , Jiawei Sun , Meng Wang , Haofen Wang

The rapid growth of medical knowledge and increasing complexity of clinical practice pose challenges. In this context, large language models (LLMs) have demonstrated value; however, inherent limitations remain. Retrieval-augmented…

Large Language Models (LLMs) and Knowledge Graphs (KGs) offer a promising approach to robust and explainable Question Answering (QA). While LLMs excel at natural language understanding, they suffer from knowledge gaps and hallucinations.…

Machine Learning · Computer Science 2025-04-15 Jasper Linders , Jakub M. Tomczak
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