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We explore a suite of generative modelling techniques to efficiently navigate and explore the complex landscapes of odor and the broader chemical space. Unlike traditional approaches, we not only generate molecules but also predict the odor…

Machine Learning · Computer Science 2025-02-03 Mrityunjay Sharma , Sarabeshwar Balaji , Pinaki Saha , Ritesh Kumar

The growing demand for molecules with tailored properties in fields such as drug discovery and chemical engineering has driven advancements in computational methods for molecular design. Machine learning-based approaches for de-novo…

Machine Learning · Computer Science 2025-04-29 Nandan Joshi , Erhan Guven

Navigation by scent is a capability in robotic systems that is rising in demand. However, current methods often suffer from ambiguities, particularly when robots misattribute odours to incorrect objects due to limitations in olfactory…

Robotics · Computer Science 2025-09-23 Kordel K. France , Ovidiu Daescu

Predicting the relationship between a molecule's structure and its odor remains a difficult, decades-old task. This problem, termed quantitative structure-odor relationship (QSOR) modeling, is an important challenge in chemistry, impacting…

The application of deep learning techniques on aroma-chemicals has resulted in models more accurate than human experts at predicting olfactory qualities. However, public research in this domain has been limited to predicting the qualities…

Machine Learning · Computer Science 2024-06-06 Laura Sisson , Aryan Amit Barsainyan , Mrityunjay Sharma , Ritesh Kumar

In this study, we explore how the combination of synthetic biology, neuroscience modeling, and neuromorphic electronic systems offers a new approach to creating an artificial system that mimics the natural sense of smell. We argue that a…

Neural and Evolutionary Computing · Computer Science 2025-08-04 Kevin Max , Larissa Sames , Shimeng Ye , Jan Steinkühler , Federico Corradi

Generating a novel and optimized molecule with desired chemical properties is an essential part of the drug discovery process. Failure to meet one of the required properties can frequently lead to failure in a clinical test which is costly.…

Machine Learning · Computer Science 2020-10-28 Bonggun Shin , Sungsoo Park , JinYeong Bak , Joyce C. Ho

Optimizing chemical molecules for desired properties lies at the core of drug development. Despite initial successes made by deep generative models and reinforcement learning methods, these methods were mostly limited by the requirement of…

Machine Learning · Computer Science 2021-12-01 Shuangjia Zheng , Ying Song , Zhang Pan , Chengtao Li , Le Song , Yuedong Yang

Olfaction -- how molecules are perceived as odors to humans -- remains poorly understood. Recently, the principal odor map (POM) was introduced to digitize the olfactory properties of single compounds. However, smells in real life are not…

Machine Learning · Computer Science 2025-01-28 Gary Tom , Cher Tian Ser , Ella M. Rajaonson , Stanley Lo , Hyun Suk Park , Brian K. Lee , Benjamin Sanchez-Lengeling

Odor visualization translates odor information and perception into visual outcomes and arouses the corresponding olfactory synesthesia, surpassing the spatial limitation that odors can only be perceived where they are present. Traditional…

Human-Computer Interaction · Computer Science 2026-02-05 Gang Yu , Yuchi Sun , Weining Yan , Xinyu Wang , Qi Lu

Olfaction sensing in autonomous robotics faces challenges in dynamic operations, energy efficiency, and edge processing. It necessitates a machine learning algorithm capable of managing real-world odor interference, ensuring resource…

Signal Processing · Electrical Eng. & Systems 2024-07-09 Rizwana Kausar , Fakhreddine Zayer , Jaime Viegas , Jorge Dias

Molecular odor prediction has great potential across diverse fields such as chemistry, pharmaceuticals, and environmental science, enabling the rapid design of new materials and enhancing environmental monitoring. However, current methods…

Machine Learning · Computer Science 2025-02-04 HongXin Xie , JianDe Sun , Yi Shao , Shuai Li , Sujuan Hou , YuLong Sun , Yuxiang Liu

Smell's deep connection with food, memory, and social experience has long motivated researchers to bring olfaction into interactive systems. Yet most olfactory interfaces remain limited to fixed scent cartridges and pre-defined generation…

Human-Computer Interaction · Computer Science 2026-04-27 Yunge Wen , Awu Chen , Jianing Yu , Jas Brooks , Hiroshi Ishii , Paul Pu Liang

Machine learning, particularly graph learning, is gaining increasing recognition for its transformative impact across various fields. One such promising application is in the realm of molecule design and discovery, notably within the…

Machine Learning · Computer Science 2024-01-10 Nianzu Yang , Huaijin Wu , Kaipeng Zeng , Yang Li , Junchi Yan

Predicting olfactory perception directly from molecular structure is central to fragrance design that plays a role in a wide range of industries, such as perfumery, food and beverage, and health care. Among olfactory attributes, odor…

Chemical Physics · Physics 2026-05-18 Peter Fichtelmann , Julia Westermayr

Advances in neural sensing technology are making it possible to observe the olfactory process in great detail. In this paper, we conceptualize smell from a Data Science and AI perspective, that relates the properties of odorants to how they…

Neurons and Cognition · Quantitative Biology 2024-04-09 Vivek Agarwal , Joshua Harvey , Dmitry Rinberg , Vasant Dhar

Olfactory perception plays a critical role in both human and organismal interactions, yet understanding of its underlying mechanisms and influencing factors remain insufficient. Molecular structures influence odor perception through…

Machine Learning · Computer Science 2025-02-04 HongXin Xie , JianDe Sun , Yi Shao , Shuai Li , Sujuan Hou , YuLong Sun , Jian Wang

Molecular odor prediction is the process of using a molecule's structure to predict its smell. While accurate prediction remains challenging, AI models can suggest potential odors. Existing methods, however, often rely on basic descriptors…

Machine Learning · Computer Science 2025-05-02 Hong Xin Xie , Jian De Sun , Fan Fu Xue , Zi Fei Han , Shan Shan Feng , Qi Chen

Embeddings from contemporary natural language processing (NLP) models are commonly used as numerical representations for words or sentences. However, odor descriptor words, like "leather" or "fruity", vary significantly between their…

Machine Learning · Computer Science 2022-05-10 Laura Sisson

We present a generalized theoretical framework for olfactory representation and plasticity, using the theory of smooth manifolds and sheaves to depict categorical odor learning via distributed neural computation. Beginning with the space of…

Neurons and Cognition · Quantitative Biology 2023-10-13 Jack A. Cook , Thomas A. Cleland
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